Preforpro Prebiotic Proprietary Blend
Also known as: PreforPro, bacteriophage cocktail
Overview
PreforPro is a patented proprietary blend of bacteriophages designed to function as a non-starch, non-fiber prebiotic, specifically creating an environment conducive to growth for beneficial gut bacteria. Unlike traditional prebiotics, PreforPro does not derive from conventional sources, as it is engineered to target particular bacterial species. It supports gut health, modifies the gut microbiota composition, and reduces inflammation. Key characteristics include a small effective dose of 15mg, making it easier for consumers to intake without the need for large fiber or starch quantities. Currently, the research surrounding PreforPro is developing, guided by a small pool of clinical trials, most notably a randomized, double-blind, placebo-controlled study showcasing its potential benefits.
Benefits
Evidence suggests that PreforPro offers several benefits, particularly for individuals with gastrointestinal distress. A significant 28-day study indicated that PreforPro led to modifications in gut microbiota, notably an increase in *Eubacterium* and fermentation taxa capable of butyrate production, contributing to a healthier gut environment. Additionally, it showed a marked reduction in the pro-inflammatory cytokine IL-4, indicating potential anti-inflammatory effects. While some changes in gut microbiota were observed, they were minor and did not induce dysbiosis, demonstrating its careful modulation of gut bacteria. However, the current data is primarily focused on healthy adults, indicating a need for further research in diverse populations.
How it works
PreforPro operates by selectively targeting and enhancing the growth of specific beneficial bacterial species in the gut, such as *B. breve*, *L. acidophilus*, and *L. paracasei*. This modulation of gut microbiota influences the production of short-chain fatty acids (SCFAs) while affecting lipid metabolism and inflammation markers. The mechanisms, primarily involving bacterial interactions, suggest that PreforPro promotes a balanced gut environment and suppresses pathogenic bacteria.
Side effects
PreforPro is generally recognized as safe and well-tolerated, with available studies indicating minimal disruption to the gut microbiota. No common (>5%), uncommon (1-5%), or rare (<1%) side effects have been documented in the clinical trials conducted thus far. There is also a lack of information regarding potential drug interactions or contraindications specific to PreforPro. Additionally, the safety in special populations, including pregnant women, children, and individuals with compromised immune systems, has not been adequately evaluated, warranting caution for these groups until more comprehensive data becomes available.
Dosage
The clinically effective dose of PreforPro is established at 15mg per day, which has shown promise for gut health in the trial settings. However, no extensive research suggests optimal ranges beyond this daily intake, and no upper limits or maximum safe doses have been confirmed. Timing of supplementation does not appear critical as long as it is consumed daily, and the small dose is designed to appeal to consumers wary of larger fiber or starch-based prebiotics. Specific absorption factors or required cofactors for performance have not been discussed in the literature.
FAQs
How should I take PreforPro?
PreforPro is taken in a daily dose of 15mg, and specific timing is not critical for its effectiveness.
Is PreforPro safe to use?
Research indicates that PreforPro is well-tolerated, but more studies are needed to fully understand its safety profile in various populations.
What benefits can I expect from taking PreforPro?
Users may see improvements in gut microbiota and reductions in inflammation, particularly if experiencing gastrointestinal distress.
What makes PreforPro different from traditional prebiotics?
Unlike fiber-based prebiotics, PreforPro is a bacteriophage cocktail that targets specific bacteria instead of relying on large amounts of dietary fiber.
Can anyone take PreforPro?
While generally safe, the effects in pregnant women, children, or immunocompromised individuals have not been adequately studied.
Research Sources
- https://nutraceuticalbusinessreview.com/deerland-preforpro-effect-on-gut-microbiota-gets-scientific-support-153418 – This article discusses the favorable effects of PreforPro on gut microbiota, supported by recent studies, emphasizing its unique properties as a non-fiber prebiotic.
- https://pubmed.ncbi.nlm.nih.gov/29704110/ – This publication highlights a clinical trial on PreforPro, illustrating its significant impact on gut microbiota composition and anti-inflammatory cytokine levels in healthy adults.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1141355/full – This study provides an in-depth analysis of the mechanisms behind various prebiotics, contextualizing PreforPro's effects on the gut and its potential benefits.
- https://www.wholefoodsmagazine.com/articles/9237-deerland-prebiotic-preforpro-shown-to-support-gut-microbiota – The article outlines key findings on how PreforPro supports gut health through its unique mechanism of action, including changes in microbiota and inflammatory markers.
- https://pubmed.ncbi.nlm.nih.gov/38064222/ – This source provides a systematic review of probiotics and their roles in health, setting a background for understanding the significance of studies related to PreforPro.
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