Sytrinol
Also known as: Sytrinol, polymethoxylated flavones, naringenin
Overview
Sytrinol is a patented dietary supplement derived from the peels of citrus fruits, primarily oranges and tangerines. This supplement is rich in active compounds, particularly polymethoxylated flavones (PMFs) and naringenin, known for their strong antioxidant properties. Sytrinol is primarily employed to promote cardiovascular health, focusing on optimizing lipid profiles by lowering total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels while potentially raising high-density lipoprotein cholesterol (HDL-C) levels. The efficacy of Sytrinol in reducing cholesterol has been moderate, particularly in individuals with hypercholesterolemia. The active compounds are believed to work by inhibiting the enzyme HMG-CoA reductase, integral to cholesterol production, and stimulating the excretion of bile acids. Additional studies are needed to confirm its long-term health impacts and effectiveness.
Benefits
1. **Lipid Profile Improvement**: Sytrinol has demonstrated reliable reductions in total cholesterol (average decrease of 13.4 mg/dL) and LDL-C levels (10.3 mg/dL) with statistical significance (p < 0.001). This evidence strongly supports its use for lipid management. 2. **Weight Management**: Preliminary studies suggest potential weight loss effects, although this remains inconclusive and requires further research. 3. **Population-Specific Effects**: Notable reductions in LDL-C levels have been observed specifically in adults diagnosed with hypercholesterolemia, underscoring Sytrinol's relevance in managing cardiovascular risk in this group.
How it works
Sytrinol primarily acts by inhibiting HMG-CoA reductase, reducing cholesterol synthesis in the liver. This suppression of cholesterol production is complemented by the promotion of bile acid excretion, which utilizes cholesterol for its formation. This dual mechanism effectively facilitates cholesterol regulation and improves overall lipid profiles by influencing hepatic cholesterol metabolism.
Side effects
Sytrinol is generally safe when used as directed. However, gastrointestinal discomfort, such as nausea, diarrhea, and stomach upset, has been documented in over 5% of users. Other less common side effects occurring in 1-5% of users include headaches, dizziness, and allergic reactions. Rare adverse events are reported in less than 1% of cases. Due to the potential for interactions, caution is advised for individuals taking statins or other cholesterol-lowering medications. Pregnant or breastfeeding women, as well as individuals with existing liver concerns, should consult healthcare professionals before using Sytrinol due to an unclear safety profile in these populations.
Dosage
The recommended dosage of Sytrinol for improving lipid profiles is between 300 mg to 600 mg per day, with the most effective minimum dosage being 300 mg. To optimize absorption and compliance, it is suggested to divide the daily dosage into two to three servings, ideally taken with meals. While there is no established upper limit, higher dosages beyond 600 mg are not frequently researched. Taking Sytrinol alongside fatty foods can further enhance absorption and minimize gastrointestinal side effects.
FAQs
Is Sytrinol safe?
Generally, Sytrinol is considered safe, especially at recommended doses. However, it should be used under medical supervision if you are on medications or have underlying health issues.
When should I take Sytrinol?
It is best taken with meals to minimize side effects and enhance absorption.
How soon can I expect results?
Improvements in lipid profiles are typically observable within several weeks to a few months of starting supplementation.
Can I replace my cholesterol medication with Sytrinol?
Sytrinol is not a replacement for prescribed medications but may serve as a complementary therapy under medical supervision.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305790/ – This study highlights the lipid-lowering effects of Sytrinol, demonstrating statistically significant reductions in total cholesterol and LDL-C in hypercholesterolemic subjects. The randomized controlled trial supports Sytrinol's efficacy but emphasizes the need for additional research on long-term outcomes.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631125/ – This meta-analysis reviews various studies on dietary flavonoids, including those in citrus peels, and their impacts on cardiovascular health, indicating a promising role for Sytrinol in managing cholesterol levels and overall cardiovascular risk.
