Polygonum Multiflorum Stem Extract
Also known as: He Shou Wu, Fo-ti, *Polygonum multiflorum*
Overview
*Polygonum multiflorum* (Thunb.) is a traditional Chinese herbal supplement known for its tonic and anti-aging properties, primarily derived from the plant's roots. Rich in compounds like stilbenes and anthraquinones, particularly 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), it has garnered attention for its potential effects on hair growth, liver protection, and metabolic health. Although a moderate research base supports various pharmacological effects, rigorous clinical trials are needed to ascertain definitive efficacy and safety. Typically available in processed forms to mitigate toxicity, *P. multiflorum* is widely utilized in Traditional Chinese Medicine and is associated with a growing interest in herbal remedies for age-related conditions.
Benefits
["May alleviate non-alcoholic steatosis and improve insulin resistance, with studies indicating significant improvements in hepatic lipid profiles.","Potentially promotes hair growth and reduces hair loss related to stress, as suggested by animal studies.","Exhibits anti-cancer, anti-oxidative, and anti-atherosclerotic properties, although empirical evidence remains limited.","Particularly beneficial for individuals with metabolic disorders or experiencing stress-induced hair loss."]
How it works
The extract modulates proteins related to lipid metabolism, thereby enhancing insulin sensitivity and reducing lipid accumulation in the liver. Its interaction primarily occurs within the liver and adipose tissues, promoting better metabolic health. TSG, a key active component, is known for its anti-tumor and liver-protective properties, although the exact mechanisms remain to be fully elucidated.
Side effects
["Generally considered safe when processed; however, raw *P. multiflorum* poses risks for liver injury.","Common side effects are not thoroughly documented, but gastrointestinal disturbances may occur.","Rarely, severe liver damage has been reported, highlighting the importance of using processed extracts.","Potential drug interactions have been cautioned, particularly with drugs affecting liver metabolism.","Contraindications exist for individuals with pre-existing liver conditions, and pregnant or breastfeeding women should seek healthcare advice before use."]
Dosage
["No well-established minimum effective dose exists; traditional usage varies widely.","Optimal dosages are not specifically defined, and caution is advised due to potential liver toxicity.","No recommended timing for administration has been established, and processed forms are preferred to enhance safety.","Bioavailability and absorption can vary depending on processing methods, yet specific factors affecting these remain inadequately researched."]
FAQs
Are processed forms safer?
Yes, processed forms of *P. multiflorum* are considered safer than raw extracts, which can be toxic.
What timing should I follow for administration?
There are no specific timing recommendations for taking *P. multiflorum* supplements.
What results can I expect?
It may improve metabolic health and promote hair growth, although individual results can vary.
Is it a cure for aging or hair loss?
No, it is not a cure-all; more research is needed to substantiate its efficacy.
Research Sources
- https://www.mdpi.com/2072-6643/12/8/2353 – This study indicates that *P. multiflorum* extract alleviated non-alcoholic steatosis and improved insulin sensitivity in mice, highlighting its potential metabolic benefits, although limitations due to lack of human trials are noted.
- https://pubmed.ncbi.nlm.nih.gov/26130933/ – A review summarizing key findings regarding the use of *P. multiflorum* in treating diseases such as diabetes and liver injury. It emphasizes the necessity for more rigorous clinical trials due to the existing gaps in high-quality evidence.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00364/full – This study demonstrates the potential of *P. multiflorum* to treat stress-induced hair loss in animal models, although it calls attention to the need for further human studies to verify these results.