Japanese Knotweed
Also known as: Polygonum Cuspidatum, Huzhang, Fleeceflower, Monkeyweed, itadori, Polygonum Japonicus, Kudzu
Overview
Japanese Knotweed, or Polygonum cuspidatum, is a Traditional Chinese Medicine used for circulation and heart health. It is a very good source of resveratrol, and most benefits of Japanese Knotweed may actually just be benefits of resveratrol. Polygonum Cuspidatum var. Japonicus is the species of plant most commonly referred to as Japanese Knotweed. This plant is an invasive species yet has been used traditionally in Chinese and Japanese medicine for its benefits on gastrointestinal health and circulatory health (among some other claims such as cancer prevention). Composition analysis of Japanese Knotweed reveals it to be a vessel for Resveratrol (as well as a few other compounds structurally similar to resveratrol and may act in the same way) and anthraquinone compounds that possess slight laxative effects; like Senna root but less potent. Most of the effects of Japanese Knotweed can be traced back to either the stilbenes (resveratrol) or the anthraquinones (emodin) for the circulatory and gastrointestinal help, respectively. Most research on Japanese Knotweed has been pertaining to either suppressing its invasive tendencies, or controlling it to become a large scale producer of Resveratrol for medical or supplemental usage. Limited trials have been conducted in humans, but it appears to have similar effects to resveratrol due to the resveratrol content.
Benefits
Japanese Knotweed functions primarily through its high content of resveratrol, a compound known for its antioxidant properties. Resveratrol may help improve circulation and support heart health by promoting blood flow and reducing inflammation. Additionally, the anthraquinones present in Japanese Knotweed may contribute to gastrointestinal health by providing mild laxative effects. The combined action of these compounds may lead to various health benefits, particularly in cardiovascular and digestive health.
How it works
Japanese Knotweed is often used for its potential benefits in cardiovascular health, gastrointestinal health, and possibly cancer prevention. The primary benefits include improved circulation, enhanced heart health, and support for digestive function. The resveratrol content is believed to be responsible for many of these effects, as it is known to have anti-inflammatory and antioxidant properties. Furthermore, the anthraquinones may aid in digestion and provide mild laxative effects.
Side effects
The only current human study used Japanese Knotweed at 200mg daily and standardized to 40mg Resveratrol which was effective. Although there are other bioactives in Japanese Knotweed, it may be prudent to dose it in accordance to the dosing guidelines on the resveratrol page.
Dosage
Japanese Knotweed is generally considered safe when used appropriately. However, potential side effects may include gastrointestinal discomfort, diarrhea, and allergic reactions in some individuals. It is important to consult with a healthcare provider before starting any new supplement, especially for those with underlying health conditions or those taking medications.
FAQs
What are the alternative names for Japanese Knotweed?
Japanese Knotweed is also known as Polygonum Cuspidatum, Huzhang, Fleeceflower, Monkeyweed, itadori, Polygonum Japonicus, and Kudzu.
How does Japanese Knotweed work in the body?
Japanese Knotweed functions primarily through its high content of resveratrol, which may help improve circulation and support heart health by promoting blood flow and reducing inflammation.
What are the benefits of Japanese Knotweed?
The primary benefits include improved circulation, enhanced heart health, and support for digestive function.
What is the recommended dosage for Japanese Knotweed?
The only current human study used Japanese Knotweed at 200mg daily and standardized to 40mg Resveratrol which was effective.
Are there any side effects associated with Japanese Knotweed?
Potential side effects may include gastrointestinal discomfort, diarrhea, and allergic reactions in some individuals.
Supplements Containing Japanese Knotweed

Collagen Enhance 1000 mg
ResVitale

Resveratrol 125 mg
ResVitale

Resveratrol 250 mg
ResVitale

Ultra Fat Burner
Slimquick
Brain Science With Cereboost American Ginseng
ResVitale

Grape Seed Extract Plus Resveratrol 325 mg
ResVitale

Optimum Silver
Vitamin Research Products

Extend Plus
Vitamin Research Products

GenEssentials Greens
Genesis Today

Resveratrol Plus
Vitabase