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Kutki

Also known as: Kutki, Picrorhiza Scrophulariiflora, Katuki, Kurro, Kutkin, Picroliv, Picrolax, Picrorhiza Kurroa

Overview

Picrorhiza kurroa (Kutki or Picroliv) is a liver tonic from Ayurveda that, when used at low doses, appears to exceed milk thistle silymarins in potency. It is underresearched, but its liver protective effects and some other immunomodulatory properties hold potential. The herb itself, due solely to the kutkin molecules, appears to be potently hepatoprotective (protective of the liver) when ingested prior to or taken after exposure to a toxin. The protective effects seem to extend to all tested toxins or stressors that are known to alter liver function, and appear to also extend to states of intrinsic liver dysfunction (viral hepatitis and NAFLD from a high fat diet). Most notably it is protective against Tylenol, alcohol, and the deathcap mushroom with a potency that is greater than silymarins (the active parts of milk thistle supplementation). This fairly remarkable hepatoprotection from picrorhiza kurroa is limited by its lack of human studies, as despite the multitude of animal research on the topic there appears to only be one study in humans which showed that a very low dose of the supplement (25mg kutkin) was effective against viral hepatitis. Future studies in humans are needed to confirm its protective effects, and currently picrorhiza kurroa is a remarkably promising herb.

Benefits

Kutki works primarily through its active components, the iridoid glycosides known as picroside I and picroside II, which together are referred to as kutkin or picroliv. These compounds are believed to exert hepatoprotective effects by enhancing liver function and protecting against various toxins. The herb's protective effects are particularly noted against substances that can cause liver damage, such as acetaminophen (Tylenol), alcohol, and certain mushrooms. The exact mechanisms by which these compounds operate are still being researched, but their ability to mitigate liver stress and dysfunction is well-documented in animal studies.

How it works

The benefits of Kutki include its hepatoprotective properties, which help safeguard the liver from damage caused by toxins and stressors. It has shown potential in improving liver function in cases of viral hepatitis and non-alcoholic fatty liver disease (NAFLD). Additionally, Kutki may have immunomodulatory effects, supporting the immune system's response to infections. Its use in traditional Ayurvedic medicine highlights its role in promoting overall health and wellness, particularly in relation to liver health.

Side effects

Supplementation of picroliv (picroside I plus picroside II) appears to be most effective at 12mg/kg (the higher dose, 24mg/kg, is not significantly more effective than 12mg/kg in most cases) and this leads to a preliminary human dosage of: 130 mg for a 150lb person, 170 mg for a 200lb person, 220 mg for a 250lb person. Although the above dosage levels are ideal, lower doses also appear to be effective and the lone human study used a total picroside I and II dosage of around 25mg. If using an extract of picrorhiza kurroa, then the above dosage refers to the total picroside I and II content (kutkin or picroliv) rather than the weight of the plant itself. For example, a plant extract that is 1,000 mg and contains 4% picroliv will confer 40 mg picroliv.

Dosage

While Kutki is generally considered safe, potential side effects may include gastrointestinal discomfort, diarrhea, and allergic reactions in some individuals. Due to its liver protective effects, it is important to consult with a healthcare provider before using Kutki, especially for those with existing liver conditions or those taking medications that affect liver function. Pregnant or breastfeeding women should also seek medical advice before using this supplement.

FAQs

What is Kutki?

Kutki is a herb from Ayurveda known for its liver protective properties and potential immunomodulatory effects.

How does Kutki work?

Kutki works primarily through its active components, picroside I and picroside II, which help protect the liver from toxins and enhance liver function.

What are the benefits of Kutki?

The benefits of Kutki include hepatoprotection, support for liver function in viral hepatitis and NAFLD, and potential immune system support.

What is the recommended dosage for Kutki?

The recommended dosage for Kutki is approximately 12mg/kg, translating to about 130 mg for a 150lb person.

Are there any side effects associated with Kutki?

Potential side effects of Kutki may include gastrointestinal discomfort and allergic reactions; consulting a healthcare provider is advised.