Persimmon Extract
Also known as: Persimmon, Persimmon extract, Diospyros kaki
Overview
Persimmon extract is derived from the fruit of *Diospyros kaki*, a tree native to Asia, and is primarily investigated for its potential health benefits, particularly in weight management and as an antioxidant. Key active components include flavonoids, tannins, and carotenoids. Research suggests it may help reduce fat mass and improve body composition in overweight individuals, alongside exhibiting anti-inflammatory effects by reducing markers like TNFα. While some clinical trials support these benefits, the overall evidence quality is moderate, with a current lack of comprehensive systematic reviews or meta-analyses. It is typically consumed as a dietary supplement in extract form.
Benefits
The primary benefit of persimmon extract, supported by a randomized, double-blind, placebo-controlled trial, is its ability to significantly reduce fat mass and improve body composition in overweight subjects without significant loss of lean mass. This trial also indicated an increase in total antioxidant capacity and a decrease in tumor necrosis factor-alpha (TNFα), suggesting anti-inflammatory properties. These effects were observed over a 120-day period. The benefits are most clearly demonstrated in overweight individuals. While animal studies suggest potential hypoglycemic and hypolipidemic effects, these findings have not yet been consistently replicated in human trials. The reduction in fat mass was statistically significant (p < 0.001).
How it works
Persimmon extract is believed to exert its effects through its rich content of bioactive compounds, including flavonoids and tannins. These compounds may influence fat metabolism, potentially by affecting fat excretion and enhancing the body's antioxidant defenses. The extract appears to interact with metabolic pathways, modulating inflammatory markers such as TNFα and boosting overall antioxidant capacity. While the exact molecular targets are still under investigation, its anti-inflammatory and antioxidant actions are thought to contribute to its observed benefits in body composition and metabolic health. Specific data on its absorption and bioavailability are not yet well-documented.
Side effects
Persimmon extract is generally considered safe and well-tolerated based on available clinical trial data. No common, uncommon, or rare side effects have been reported in the literature. Furthermore, no significant drug interactions have been noted, and no specific contraindications have been identified. There are no documented warnings or special considerations for specific populations such as pregnant women, children, or elderly individuals. However, it is important to note that long-term effects and potential interactions with various medications have not been extensively studied, and individuals should consult a healthcare provider before initiating any new supplement regimen.
Dosage
The effective dose of standardized persimmon extract used in clinical trials was 400 mg per day. This dosage was administered as a dietary supplement in powder form. While this dose has shown significant benefits in reducing fat mass and improving body composition, an optimal dosage range beyond this has not been established, nor has a maximum safe dose been defined. There are no specific timing recommendations for administration, and no required cofactors have been identified. Information regarding absorption factors and bioavailability at this dosage is not detailed in current research.
FAQs
How should I take persimmon extract?
The effective dose used in studies was 400 mg per day, typically as a powder. There are no specific timing recommendations, but always consult a healthcare provider before starting.
Is persimmon extract safe?
It is generally considered safe and well-tolerated in studies, with no reported side effects or drug interactions. However, long-term safety and interactions with medications are not fully studied.
What benefits can I expect from persimmon extract?
Users may experience improvements in body composition, specifically reduced fat mass, and enhanced antioxidant status. These benefits were observed over a 120-day period in overweight individuals.
Is persimmon extract a weight loss miracle?
No, persimmon extract is not a substitute for a healthy diet and regular exercise. It may support weight management efforts, but lifestyle changes are crucial for sustainable results.
Are there any contraindications for persimmon extract?
No specific contraindications have been identified. However, individuals with underlying health conditions or those taking medications should consult a healthcare professional.
Research Sources
- https://www.mdpi.com/2304-8158/13/24/4072 – This randomized, double-blind, placebo-controlled trial investigated the effects of persimmon extract on body composition in overweight adults. It found that 400 mg/day of persimmon extract significantly reduced fat mass and improved body composition over 120 days, alongside increasing antioxidant capacity and decreasing TNFα, indicating anti-inflammatory effects.
- https://pubmed.ncbi.nlm.nih.gov/39767014/ – This PubMed entry corresponds to the same randomized, double-blind, placebo-controlled trial. It highlights the significant reduction in fat mass and improvements in body composition observed in overweight subjects receiving persimmon extract, supporting its potential role in weight management and antioxidant defense.
- https://www.spandidos-publications.com/10.3892/mmr.2015.3766 – This animal study explored the effects of persimmon leaf extract, suggesting potential hypoglycemic and hypolipidemic properties. While promising, these findings are from animal models and require further human research to confirm their relevance and efficacy in humans.
- https://pubmed.ncbi.nlm.nih.gov/16904806/ – This PubMed entry refers to an animal study investigating the effects of persimmon leaf extract. It indicates potential benefits related to blood sugar and lipid levels, but as an animal study, its direct applicability to human health outcomes needs further validation through clinical trials.
- https://www.researchgate.net/publication/250272566_Protective_Effects_of_Persimmon_Leaf_and_Fruit_Extracts_against_Acute_Ethanol-Induced_Hepatotoxicity – This research explores the protective effects of persimmon leaf and fruit extracts against acute ethanol-induced hepatotoxicity. It suggests that components within persimmon may offer liver protection, indicating broader health benefits beyond weight management, though this specific study focuses on an acute toxicity model.
