Pedalium Extract
Also known as: Dalzelli's Pedalium, Gokshura, Pedalium, Gokshura murex, *Pedalium murex* L.
Overview
*Pedalium murex* L. is a succulent herbaceous plant indigenous to India and parts of Asia, utilized in traditional medicine as a tonic, blood purifier, aphrodisiac, and appetizer. The herb is characterized by its various bioactive compounds; however, the constituents responsible for its medicinal effects remain largely unidentified. *Pedalium murex* has been investigated for its potential anticancer, anti-inflammatory, and antioxidant properties, primarily through in vitro and animal model studies. Evidence supporting its efficacy is still in the early stages, with a gap in rigorous human clinical trials and systematic reviews, indicating the need for further investigation to validate its therapeutic applications.
Benefits
{"primary_effects":{"anticancer_activity":{"description":"An in vitro study indicated that the ethyl acetate fraction of *Pedalium murex* flower extract demonstrated cytotoxic activity against the HepG2 human hepatoma cell line with an IC50 value of 144 ± 5.3 μg/ml.","evidence_strength":"Moderate","population_specificity":"Currently, no specific populations identified due to lack of clinical evidence.","effect_significance":"Statistically significant with p < 0.05, clinical relevance undetermined."}},"secondary_effects":{"antioxidant_and_anti_inflammatory":{"description":"While traditionally used for antioxidant and anti-inflammatory purposes, rigorous scientific validation is missing.","evidence_strength":"Limited peer-reviewed evidence."},"aphrodisiac_and_appetizer_properties":{"description":"Based on traditional applications, lacks comprehensive scientific backing.","evidence_strength":"Traditional use only."}},"time_course_of_benefits":"Unestablished due to insufficient long-term studies."}
How it works
The precise mechanisms of *Pedalium murex* are not fully characterized. The observed anticancer activity is believed to involve apoptosis induction and damage to cellular membrane integrity, although the detailed biological pathways and molecular targets remain unclarified in current literature.
Side effects
{"overall_safety":"The safety profile of *Pedalium murex* remains unclear owing to an absence of human clinical studies. No common, uncommon, or rare side effects have been documented in the existing literature.","drug_interactions":"No data available regarding potential drug interactions.","contraindications":"No known contraindications specified.","special_population_considerations":"Insufficient data for vulnerable groups such as pregnant women, children, or the elderly."}
Dosage
{"minimum_effective_dose":"Not established for human use.","optimal_dosage_ranges":"Unknown; in vitro studies utilized 10 μg/ml to 250 μg/ml concentrations.","maximum_safe_dose":"No definitive data available.","timing_considerations":"Not applicable.","form_specific_recommendations":"None provided in literature.","absorption_factors":"Absorption and bioavailability not documented.","required_cofactors":"None identified."}
FAQs
Is *Pedalium murex* safe for human consumption?
Its safety is not well established; caution is advised if considering use.
How should I take *Pedalium murex* supplements?
There are no established guidelines for timing or administration.
What benefits can I expect from *Pedalium murex*?
Current understanding is based on in vitro and animal data; human trials are needed for confirmation.
Is *Pedalium murex* the same as Gokshura?
It is sometimes confused with *Tribulus terrestris* (commonly called Gokshura), but it has unique properties.
Research Sources
- https://www.sphinxsai.com/2017/ch_vol10_no7/2/(509-514)V10N7CT.pdf – An in vitro study evaluating the anticancer effects of *Pedalium murex* L. flower extract, demonstrating significant cytotoxicity against HepG2 cells, confirmed through appropriate experimental methods.
- https://www.mdpi.com/1424-8247/15/4/448 – This review covers the ethnomedicinal uses, phytochemistry, and pharmacological aspects of *Pedalium murex*, underscoring the lack of comprehensive scientific validation for its traditional uses.
- https://rrpharmacology.ru/index.php/journal/article/view/434/445 – A review of *Pedalium murex* focusing on its traditional applications and some pharmacological properties, while emphasizing the need for further research on its efficacy.
- https://tnsroindia.org.in/JOURNAL/issue85/ISSUE%2085%20-%20AUG%202024%20-%20FULL%20TEXT%20PART%2003.pdf – This article presents a comprehensive outlook on the medicinal properties and the ethnobotanical significance of *Pedalium murex* in various communities.
- https://www.sciencedirect.com/science/article/abs/pii/S2210803324000745 – This study provides insights into the biochemical analysis of *Pedalium murex* and its traditionally recognized pharmacological attributes, while calling for more clinical trials to validate these uses.
