Prunus Persica Kernel Extract; Dry
Also known as: peach kernel extract, Tao Ren, peach kernel, Prunus persica kernel extract
Overview
Prunus persica kernel extract is derived from the dried mature seeds of the peach tree (*Prunus persica*) and the mountain peach (*Prunus davidiana*). Traditionally, it is used in Chinese medicine for various medicinal purposes, including promoting blood circulation, relieving cough, and functioning as a laxative. This extract is notable for containing compounds like amygdalin, which has shown potential health benefits in preliminary studies. However, while marketed for hair growth and care, the scientific evidence supporting these effects remains limited, primarily relying on traditional usage rather than robust clinical trials. Overall, the quality of available research is low, underscoring the need for further studies to establish its efficacy and safety.
Benefits
Some evidence suggests that peach kernel extract may promote hair growth by enhancing the viability and proliferation of dermal papilla cells necessary for hair follicle development. This conclusion is largely drawn from in vitro studies, which indicate activation of crucial signaling pathways, like ERK and Akt. Nevertheless, clinical validation is lacking, and there are no rigorous trials clearly demonstrating these effects. Other traditional benefits, such as blood circulation and cough relief, lack modern clinical support, highlighting a substantial gap in high-quality evidence that would confirm specific population benefits or effect sizes.
How it works
The methanol extract of Prunus persica kernel has been shown to activate the ERK and Akt signaling pathways, which are vital for cell proliferation. This suggests a potential mechanism through which the extract promotes dermal papilla cell growth, interacting directly with hair follicle cells. However, systemic impacts and broader biological interactions remain poorly understood, and further research is necessary to clarify these mechanisms.
Side effects
Overall, Prunus persica kernel extract is generally regarded as safe when used as directed; however, comprehensive data on long-term safety is lacking. Side effects have not been well-documented due to limited clinical trials, which diminishes the understanding of common, uncommon, or rare adverse effects. Potential interactions with anticoagulants or medications affecting blood circulation are speculative and warrant caution. Individuals with bleeding disorders should approach its use with care. Pregnant or breastfeeding women are advised to seek medical consultation prior to use, given the limited safety data available.
Dosage
Currently, there is no established minimum effective dose for peach kernel extract, particularly regarding hair growth or other benefits. Traditional dosages can vary widely, and optimal ranges are not standardized across practices. No maximum safe dose has been defined, and specific timing guidelines for administration are unavailable. This extract is often utilized in oil or extract form in traditional medicine. Absorption factors remain unknown, and no required cofactors have been identified, indicating the need for further exploration into effective dosing strategies.
FAQs
What is the primary use of Prunus persica kernel extract?
It is primarily used in traditional Chinese medicine for promoting blood circulation, relieving cough, and is marketed for hair growth, though evidence for these claims is limited.
Is it safe to use peach kernel extract?
Generally considered safe for short-term use, but long-term safety and interactions with other medications are not well-studied.
What dosage should I take?
There is no standardized dosage for hair growth; traditional uses vary, and optimal dosages have not been established.
Can it help with hair growth?
Some in vitro studies suggest potential benefits for hair growth, but clinical validation is lacking, and evidence remains speculative.
What are the side effects?
Side effects are not well-documented. Potential risks include interactions with anticoagulants and are advised against in individuals with bleeding disorders.
Research Sources
- https://www.ijpsonline.com/articles/methanol-extract-of-peach-kernel-induces-human-hair-follicle-dermal-papilla-cell-proliferation-emviaem-the-extracellular-signalreg-5614.html?view=mobile – This study demonstrates that methanol extract from peach kernel can induce proliferation in human hair follicle dermal papilla cells by activating the ERK and Akt pathways. However, the methodology and small sample size limit the findings' robustness.
- https://www.researchgate.net/publication/372077188_Peach_Prunus_persica_L_Batsch_seeds_and_kernels_as_potential_plant-based_functional_food_ingredients_A_review_of_bioactive_compounds_and_health-promoting_activities – This review provides an overview of health-promoting activities of peach seeds and kernels, highlighting bioactive compounds. While traditional uses are discussed, rigorous clinical evidence to support these claims is lacking, emphasizing the need for more research.