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Osteomove Ultra Fruit Polyphenol Complex

Also known as: Polyphenol-rich extracts, Fruit polyphenols, Flavonoids, Quercetin, Phenolic acids, Stilbenes, Resveratrol, Polyphenols

Overview

Polyphenols are a diverse group of naturally occurring compounds found abundantly in plant-based foods such as fruits, vegetables, nuts, seeds, and beverages like tea and wine. They are characterized by their multiple phenol units and are well-known for their antioxidant properties. Polyphenols are categorized into several classes, including flavonoids (e.g., quercetin), phenolic acids, stilbenes (e.g., resveratrol), and lignans. These compounds are investigated for their potential health benefits, primarily related to their antioxidant and anti-inflammatory effects. Research suggests that polyphenols may play a role in protecting against chronic diseases, such as cardiovascular diseases, neurodegenerative disorders, and certain types of cancer. They are available in various forms, including dietary supplements and extracts, but are best obtained through a balanced diet rich in whole foods. The quality of evidence supporting their benefits varies, with some high-quality systematic reviews and meta-analyses available.

Benefits

Polyphenols offer several potential health benefits, primarily due to their antioxidant and anti-inflammatory properties. Quercetin, a type of polyphenol, has been shown to improve endurance performance in healthy individuals, as indicated by systematic reviews and meta-analyses. Other polyphenols, like resveratrol, may contribute to bone health by reducing bone mineral density loss and decreasing fracture risk, potentially by promoting osteoblast differentiation and inhibiting osteoclast activity, according to in vitro and animal studies. Postmenopausal women may particularly benefit from the bone-health effects of polyphenols. While moderate improvements in performance and bone health markers have been observed, the clinical significance and long-term effects are still under investigation. Benefits may be observed within weeks to months of consistent supplementation.

How it works

Polyphenols exert their effects through multiple biological pathways. Primarily, they act as antioxidants, neutralizing free radicals and reducing oxidative stress. They also modulate inflammatory responses by influencing various signaling pathways. In the context of bone health, polyphenols like resveratrol can affect bone metabolism by influencing osteoblasts (bone-building cells) and osteoclasts (bone-resorbing cells). Specifically, they can modulate signaling pathways involved in bone metabolism, such as the OPG/RANKL pathway. The absorption and bioavailability of polyphenols vary depending on the specific compound and its formulation. Generally, bioavailability is low but can be enhanced by certain formulations or when consumed with food.

Side effects

Polyphenols are generally considered safe when consumed in moderate amounts, but some side effects have been reported. Common side effects, occurring in more than 5% of users, include gastrointestinal upset. Uncommon side effects, affecting 1-5% of users, may include allergic reactions. Rare but severe allergic reactions can occur in less than 1% of users. Polyphenols may interact with blood thinners and certain other medications due to their antioxidant effects, potentially altering their efficacy. While contraindications are not well-documented, caution is advised during pregnancy and breastfeeding due to limited safety data. Elderly individuals may benefit from the bone health effects of polyphenols, but caution is warranted due to potential interactions with medications they may be taking. It is important to monitor for any adverse effects and consult with a healthcare provider before starting polyphenol supplementation, especially if you have existing health conditions or are taking medications.

Dosage

The minimum effective dose of polyphenols is not well-established and varies depending on the specific polyphenol. Optimal dosage ranges typically fall between 500 mg to 1,000 mg per day for general health benefits. The maximum safe dose is not well-defined, and high doses may increase the risk of side effects. It is generally recommended to take polyphenols with meals to enhance absorption. Bioavailability can vary significantly depending on the form, such as extracts versus whole foods. Absorption can be influenced by food intake and specific formulations. While no specific cofactors are required, vitamin C may enhance the absorption of some polyphenols. It is important to start with a lower dose and gradually increase it to assess tolerance and minimize potential side effects.

FAQs

Are polyphenols safe to take?

Polyphenols are generally safe for most people when taken in moderate amounts. However, some individuals may experience gastrointestinal side effects. It's best to start with a lower dose to assess tolerance.

When is the best time to take polyphenols?

Polyphenols are best taken with meals to enhance absorption. This can help improve their bioavailability and reduce the likelihood of gastrointestinal discomfort.

How long does it take to see the benefits of polyphenols?

It may take several weeks to months of consistent supplementation to notice the benefits of polyphenols. Individual responses can vary, and it's important to maintain a balanced diet.

Can I get enough polyphenols from my diet alone?

Yes, a balanced diet rich in fruits, vegetables, nuts, and seeds can provide a good source of polyphenols. Whole foods are often preferred over supplements for overall health.

Are there any drug interactions with polyphenol supplements?

Polyphenols may interact with blood thinners and certain other medications due to their antioxidant effects. Consult with a healthcare provider if you are taking medications.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/28097488/ – This systematic review and meta-analysis investigated the effects of polyphenols, particularly quercetin, on exercise performance. The study found that polyphenol supplementation may improve endurance performance in healthy individuals and athletes. However, the authors noted that the quality of studies and outcomes varied, suggesting the need for further research.
https://www.journalbonefragility.com/wp-content/uploads/journal/2022/2.3/97-101.pdf – This study explores the potential of resveratrol, a polyphenol, in promoting bone health. It highlights resveratrol's ability to modulate bone metabolism by affecting osteoblast and osteoclast activity. The research suggests that resveratrol could be a promising agent for reducing bone mineral density loss and decreasing fracture risk, particularly in postmenopausal women.
https://www.mdpi.com/2218-273X/14/7/836 – This review discusses the role of polyphenols in bone metabolism, focusing on their effects on osteoblasts and osteoclasts. The study suggests that polyphenols like resveratrol can modulate bone metabolism by affecting osteoblast and osteoclast activity. While the findings are promising, the authors note that more human studies are needed to confirm these effects.
https://pubmed.ncbi.nlm.nih.gov/37891909/ – This systematic review and meta-analysis focuses on the impact of polyphenols on bone health in postmenopausal women. The study indicates that polyphenol supplementation may support bone health by reducing bone mineral density loss in this population. The authors acknowledge the need for more long-term studies to fully understand the effects of polyphenols on bone health.
https://www.fisiologiadelejercicio.com/wp-content/uploads/2017/04/Polyphenols-and-Performance.pdf – This review examines the relationship between polyphenols and exercise performance. It suggests that polyphenols, particularly quercetin, may improve performance. The authors emphasize the importance of considering the type of polyphenol, dosage, and individual characteristics when evaluating the effects of polyphenol supplementation on exercise performance.