Organic Turkey Tail mycelia
Also known as: Trametes versicolor, Coriolus versicolor, Turkey Tail mushroom, Cloud mushroom, Kawaratake
Overview
Turkey Tail (*Trametes versicolor*) is a medicinal mushroom recognized for its immunomodulatory and potential anticancer properties. Found globally on decaying hardwoods, it's been used in traditional East Asian medicine for centuries. The supplement is typically derived from hot-water extracts of the fruiting bodies or mycelia to concentrate its key bioactive polysaccharides, including polysaccharide peptide (PSP) and polysaccharide krestin (PSK). These compounds are known for stimulating immune cells and modulating the gut microbiome. Turkey Tail is used primarily as an adjunct in cancer therapy to improve survival rates and quality of life, as well as for general immune system support. Research includes numerous clinical trials, systematic reviews, and meta-analyses, supporting its benefits, particularly in cancer treatment.
Benefits
Turkey Tail offers several evidence-based benefits. As a cancer adjunct therapy, a meta-analysis showed a significant reduction in mortality risk (approximately 9%) and improved overall survival when used with conventional treatments. It enhances immune function by elevating levels of CD4+ and CD8+ T cells. Its polysaccharides act as prebiotics, promoting beneficial gut bacteria like *Bifidobacterium* and *Lactobacillus*, while reducing harmful bacteria. Preclinical studies suggest potential benefits for bone health by stimulating osteoblast growth and inhibiting osteoclast formation, and for blood glucose regulation with anti-hyperglycemic effects. It also improves quality of life measures in cancer patients, such as fatigue reduction.
How it works
Turkey Tail's primary mechanism of action involves immunomodulation through the activation of innate and adaptive immune cells. Its polysaccharides bind to pattern recognition receptors, such as Toll-like receptors, on immune cells, stimulating macrophages, NK cells, and T lymphocytes. Additionally, it acts as a prebiotic, enhancing beneficial gut microbiota and reducing systemic inflammation. Preclinical studies indicate that it may stimulate osteoblast activity and inhibit osteoclasts, contributing to bone remodeling. While polysaccharides are not directly absorbed, they exert local effects in the gut and indirectly stimulate systemic immune responses.
Side effects
Turkey Tail is generally considered safe, with mild gastrointestinal discomfort (bloating, gas) being the most commonly reported side effect. Uncommon side effects include allergic reactions in sensitive individuals. Serious adverse events are rare. Caution is advised when using Turkey Tail with immunosuppressive drugs, and it is contraindicated for individuals with autoimmune diseases. Safety during pregnancy and lactation is not well established. While clinical trials have not reported significant adverse effects, it's important to monitor for potential interactions with other medications and to discontinue use if any adverse reactions occur.
Dosage
Clinical studies commonly use standardized extracts containing 1-3 grams per day of polysaccharide-rich Turkey Tail extract. A typical dosage in cancer adjunct studies is 3 grams daily of a hot-water extract standardized for PSP/PSK. While no established upper limit exists, doses up to 9 grams daily have been used without serious adverse effects. It is typically taken daily with meals to enhance absorption and reduce gastrointestinal discomfort. Hot-water extracts of fruiting bodies or mycelia are preferred for their polysaccharide content, as raw mushroom powder is less effective. General nutritional support is recommended alongside supplementation.
FAQs
Is Turkey Tail mycelia as effective as fruiting body extracts?
Both contain polysaccharides, but fruiting body extracts are more extensively studied. Mycelial extracts may vary in composition and require standardization to ensure consistent efficacy.
How long before benefits appear?
Immune and microbiome effects may appear within weeks of supplementation. Cancer survival benefits, however, typically require months to years of consistent use.
Is it safe to use alongside chemotherapy?
Yes, Turkey Tail extracts are commonly used as adjuncts in chemotherapy. No significant adverse interactions have been reported in clinical trials.
Can it cure cancer?
No, Turkey Tail is not a standalone cure for cancer. It is an adjunct therapy that may improve survival rates and quality of life when used in conjunction with conventional treatments.
Research Sources
- https://www.webmd.com/vitamins/ai/ingredientmono-648/turkey-tail-mushroom – This WebMD summary provides an overview of clinical data on Turkey Tail mushroom, highlighting the immunomodulatory and anticancer properties of PSP and PSK polysaccharides. It notes the approval of Turkey Tail in Japan as an adjunct therapy for cancer treatment. While not a primary research source, it aligns with findings from primary literature.
- https://mycomedicine.org/turkey-tail-mushroom-benefits-a-clinical-review/ – This clinical review discusses the benefits of Turkey Tail mushroom, focusing on its impact on the immune system and its potential role in cancer treatment. It summarizes various clinical trials and preclinical studies, emphasizing the role of polysaccharides in modulating immune responses. The review highlights the importance of standardized extracts for consistent results.
- https://drnoelsmushroompowder.com/blogs/mushroom-research/turkey-tail-cancer-benefits-how-the-mushroom-may-help-fight-cancer – This blog post summarizes research on the cancer benefits of Turkey Tail mushroom, explaining how it may help fight cancer. It discusses the mechanisms by which Turkey Tail supports the immune system and its potential to improve outcomes in cancer patients. The post emphasizes the importance of using high-quality Turkey Tail products for optimal results.
- https://www.verywellhealth.com/turkey-tail-mushroom-6890534 – This article from Verywell Health provides an overview of Turkey Tail mushroom, including its uses, benefits, and potential side effects. It discusses the research supporting its use as an immune-boosting supplement and its potential role in cancer treatment. The article also highlights the importance of consulting with a healthcare professional before using Turkey Tail.
- https://www.mushroomculture.co.uk/turkey-tail-information – This resource provides general information about Turkey Tail mushroom, including its identification, habitat, and traditional uses. It discusses the bioactive compounds found in Turkey Tail and their potential health benefits. The information is intended for educational purposes and does not provide medical advice.
Supplements Containing Organic Turkey Tail mycelia
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