Organic Neurofactor Whole Coffee
Also known as: Whole Coffee Cherry Extract (WCCE), Organic Neurofactor Whole Coffee, Whole Coffee Fruit Extract (WCFC), NeuroFactor™, Coffea arabica (Whole Coffee Cherry Extract)
Overview
Whole coffee cherry extract (WCCE), derived from *Coffea arabica*, is a polyphenol-rich botanical supplement gaining attention for its potential cognitive benefits. It contains a unique profile of polyphenols, including chlorogenic acids, while maintaining a low caffeine content (typically <2%). The primary application of WCCE lies in its ability to increase brain-derived neurotrophic factor (BDNF) levels, a crucial protein for neuronal health and plasticity. Available in forms like capsules, WCCE is being explored for its potential to enhance cognitive functions, particularly alertness and focus. While research is still emerging, with most studies focusing on healthy adults, the initial findings suggest a promising role for WCCE in supporting cognitive well-being. Further research is needed to fully elucidate its long-term effects and benefits across diverse populations.
Benefits
The primary benefit of whole coffee cherry extract (WCCE) is its ability to increase plasma BDNF levels. Studies have demonstrated significant increases, ranging from 91% to 143% compared to baseline, following WCCE consumption. This effect is observed acutely, typically within 60 minutes of ingestion. Emerging evidence suggests potential secondary benefits, such as improvements in alertness and reductions in fatigue, although these are less extensively studied. Most research has focused on healthy adults, and the clinical significance of increased BDNF for cognitive function remains an area of ongoing investigation. While the observed increases in BDNF are statistically significant, more research is needed to determine the long-term cognitive benefits and optimal usage of WCCE.
How it works
Whole coffee cherry extract (WCCE) primarily works by increasing levels of brain-derived neurotrophic factor (BDNF). BDNF is a key protein involved in neuronal survival, growth, and plasticity. By elevating BDNF levels, WCCE may enhance neural plasticity and provide neuroprotective effects. The exact mechanisms by which WCCE increases BDNF are not fully understood, but it is hypothesized that the polyphenols present in the extract play a crucial role. These polyphenols may interact with signaling pathways that regulate BDNF expression, ultimately leading to increased BDNF production and release in the brain.
Side effects
Whole coffee cherry extract (WCCE) is generally considered safe, but comprehensive long-term safety data are currently limited. Common side effects are not well-documented, but potential adverse effects may include mild gastrointestinal upset, although this has not been specifically reported in studies. Rare side effects are unknown due to the limited data available. Potential drug interactions may exist with medications that affect BDNF levels or polyphenol metabolism, but these interactions are not well-studied. Caution is advised for pregnant or breastfeeding women due to the lack of safety data in these populations. Individuals with known sensitivities to coffee or polyphenols should also exercise caution. Further research is needed to fully characterize the safety profile of WCCE.
Dosage
The minimum effective dose of whole coffee cherry extract (WCCE) for increasing BDNF levels is 100 mg, which has been used in several studies. An optimal dosage range has not been definitively established, but 100 mg is the most commonly studied dose. The maximum safe dose is also not well-defined, and caution is advised when exceeding 100 mg without further research. Acute effects on BDNF levels have been observed within 60 minutes of ingestion. WCCE is commonly available in capsule form. Individual bioavailability may vary. Long-term dosing effects remain unknown. No specific cofactors are required for WCCE to exert its effects.
FAQs
How long does it take to see effects from whole coffee cherry extract?
Effects on BDNF levels are observed acutely, typically within 60 minutes of ingestion. However, the long-term cognitive benefits are still speculative and require further research.
Is whole coffee cherry extract safe?
It is generally considered safe, but consult a healthcare provider for specific concerns, especially if you have underlying health conditions or are taking medications.
How should I take whole coffee cherry extract?
Take as directed on the product label. Timing may not be critical for acute effects, but consistency is generally recommended for any potential long-term benefits.
What results can I expect from taking whole coffee cherry extract?
You can expect an increase in BDNF levels. Potential cognitive benefits are being researched, but are not yet definitively established.
Is whole coffee cherry extract a substitute for medical treatment?
No, it is not a substitute for medical treatment. Its cognitive benefits are not well-established, and it should not be used in place of prescribed medications or therapies.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7909261/ – This randomized, double-blind, within-subject, cross-over study on older adults investigated the effects of whole coffee cherry extract (WCCE) on BDNF levels and cognitive functions. The study found that WCCE increased BDNF levels and potentially improved cognitive functions, but the small sample size and lack of long-term data were limitations, resulting in a moderate quality assessment.
- https://pubmed.ncbi.nlm.nih.gov/23312069/ – This single-dose study examined the impact of whole coffee fruit concentrate (WCFC) on plasma BDNF levels in healthy subjects. Results indicated that WCFC increased plasma BDNF by 143% compared to baseline within 120 minutes post-ingestion. The study's limitations include a small sample size and short duration, leading to a moderate quality assessment.
- https://www.scirp.org/journal/paperinformation?paperid=36447 – This within-subject crossover study assessed the effects of whole coffee fruit concentrate (WCFC) on plasma BDNF levels in healthy adults aged 25-35. The study demonstrated that WCFC significantly increased plasma BDNF levels within a short duration. The small sample size and short duration of the study were noted as limitations, resulting in a moderate quality assessment.
- https://west.supplysideshow.com/content/dam/Informa/westsupplysideshow/sposnorshipassets/Neurofactor%20flyer.pdf – This flyer provides promotional information about NeuroFactor, highlighting its potential cognitive benefits and ability to increase BDNF levels. It is important to note that this is a marketing material and should be interpreted with caution, as it may not present a balanced view of the scientific evidence.
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Coffee-fruit-Cognitive-Vitality-For-Researchers.pdf – This document from the Alzheimer's Drug Discovery Foundation summarizes the cognitive vitality of coffee fruit for researchers. It highlights the potential benefits of coffee fruit extract in increasing BDNF levels and supporting cognitive function, while also acknowledging the need for further research to confirm these effects.
