Ophiopogon
Also known as: Dwarf Lilyturf, Mondo Grass, Liriope, Mai Dong, Ophiopogon japonicus
Overview
Ophiopogon japonicus, also known as Dwarf Lilyturf or Mondo Grass, is a plant native to East Asia. It is commonly used in traditional Chinese medicine, where its roots are valued for their purported health benefits. The plant contains various bioactive compounds, including polysaccharides and saponins. Traditionally, it has been used to address respiratory issues, fever, and as a general tonic. Modern research is increasingly focused on its potential anticancer and immunomodulatory effects. While the quality of available evidence varies, there is growing interest in its pharmacological properties, warranting further rigorous clinical trials to validate its efficacy and safety.
Benefits
Research suggests that Ophiopogon japonicus may possess anticancer properties, potentially inducing apoptosis and cell cycle arrest in cancer cells. Some studies indicate that it may improve cough-related quality of life when used as part of herbal medicine formulations. Additionally, it may enhance immune function and exhibit anti-inflammatory effects. However, the effect sizes and clinical significance of these benefits are not well-quantified in human studies, and more research is needed to establish the time course of these benefits and to identify specific populations that may benefit most.
How it works
Ophiopogon japonicus is believed to exert its effects through multiple biological pathways. Its anticancer properties may stem from the induction of apoptosis and cell cycle arrest in cancer cells. The polysaccharides and other compounds present in the plant may also play a role in immunomodulation. While the exact molecular targets are not well-defined, it is thought to interact with immune and cellular systems. Limited data are available regarding its absorption and bioavailability, which necessitates further investigation to fully understand its mechanism of action.
Side effects
While Ophiopogon japonicus is generally considered safe when used traditionally, comprehensive safety data are lacking. Common, uncommon, and rare side effects are not well-documented. Potential drug interactions, particularly with immunosuppressive drugs or other herbal supplements, should be considered. Due to limited data, caution is advised during pregnancy and lactation. Similarly, there is limited information on its use in children or individuals with severe health conditions. Further research is needed to fully characterize its safety profile and potential adverse effects.
Dosage
Currently, there is no established minimum effective dose or maximum safe dose for Ophiopogon japonicus. Traditionally, it is used in decoctions or as part of herbal formulas, with specific dosages varying depending on the formulation and intended use. Timing considerations and form-specific recommendations are not well-established. Given the limited data on absorption factors and required cofactors, it is crucial to consult with a healthcare provider or qualified herbalist to determine appropriate and safe dosages. More research is needed to define optimal dosage ranges and safety thresholds.
FAQs
Is Ophiopogon japonicus safe to use?
While traditionally used, comprehensive safety data are lacking. Consult a healthcare provider before using, especially if combining with other medications.
How should I take Ophiopogon japonicus?
Timing and administration are not well established. It is often used as a root extract or in combination with other herbs. Consult with a qualified herbalist for guidance.
What results can I expect from using Ophiopogon japonicus?
Expected results are variable, depending on the condition being treated. There is a belief in broad efficacy without sufficient clinical evidence, so manage expectations accordingly.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/36854203/ – A systematic review of in vitro and in vivo studies suggests that Ophiopogon japonicus extracts show potential anticancer effects through mechanisms like apoptosis and cell cycle arrest. However, the review highlights the absence of human clinical trials, indicating that more research is needed to confirm these findings in humans.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1230604/full – A systematic review and meta-analysis involving 7,573 patients found that herbal medicine, which may include Ophiopogon japonicus, improves cough-related quality of life and reduces recurrence rates. The authors note that there is a high risk of bias in the included studies, leading to moderate to low certainty of evidence.
- https://journals.lww.com/md-journal/fulltext/2020/08280/traditional_chinese_medicine_xiaosheng_powder_for.99.aspx – A protocol for a systematic review and meta-analysis suggests that Xiaosheng Powder, containing Ophiopogon japonicus, may have anti-inflammatory effects beneficial for dry eye disease. This is a study protocol, so no completed review is available, and the quality assessment is not applicable at this stage.
- https://onlinelibrary.wiley.com/doi/10.1155/2019/9458676 – This review discusses the phytochemistry, ethnomedicinal uses, and pharmacological properties of Ophiopogon japonicus. It highlights the presence of various bioactive compounds and their potential therapeutic applications, supporting the traditional use of this plant in treating various ailments.
- https://www.researchgate.net/publication/292185801_Ophiopogon_japonicus-A_phytochemical_ethnomedicinal_and_pharmacological_review – This review provides an overview of the phytochemical, ethnomedicinal, and pharmacological aspects of Ophiopogon japonicus. It consolidates information on its traditional uses and potential therapeutic benefits, emphasizing the need for further research to validate these claims.
