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Omnixan

Also known as: OmniXan, natural zeaxanthin from paprika, zeaxanthin, RR-zeaxanthin

Overview

OmniXan is a branded form of RR-zeaxanthin, a stereoisomer of zeaxanthin, which is a carotenoid pigment. It is a natural extract derived from paprika (Capsicum annuum). Zeaxanthin is a dietary carotenoid that concentrates in the macula of the human eye. Its primary use is for supporting eye health, particularly to increase macular pigment optical density (MPOD) and potentially reduce the risk or slow the progression of age-related macular degeneration (AMD). RR-zeaxanthin is one of three macular carotenoids (along with lutein and meso-zeaxanthin) that accumulate in the retina, where they act as powerful antioxidants and filters for harmful blue light. OmniXan is recognized for its natural origin and high purity. While zeaxanthin and related carotenoids have been extensively studied for eye health, specific independent clinical data on the OmniXan brand itself is more limited. However, the overall evidence for zeaxanthin's efficacy and safety is robust, with GRAS (Generally Recognized As Safe) status affirmed by independent panels.

Benefits

Zeaxanthin supplementation, including the RR-zeaxanthin found in OmniXan, primarily benefits eye health by increasing macular pigment optical density (MPOD). Higher MPOD is associated with improved visual performance and potential protection against the progression of age-related macular degeneration (AMD). A 2021 systematic review and meta-analysis highlighted that lutein/zeaxanthin intake significantly increased MPOD, underscoring their role in maintaining ocular health. Beyond MPOD, zeaxanthin's potent antioxidant properties help reduce oxidative stress in retinal tissues, which is crucial for preventing cellular damage. Some studies also suggest modest improvements in visual acuity and contrast sensitivity. These benefits are most pronounced in older adults, especially those at risk for or with early stages of AMD. While MPOD increases are statistically significant, the clinical impact on AMD progression is supported but can be modest and varies across individuals and studies. Benefits typically become observable after several months of consistent supplementation, often 6 to 24 months, as seen in clinical trials.

How it works

RR-zeaxanthin, the active compound in OmniXan, functions primarily by accumulating in the macula, a central part of the retina. Once there, it performs two critical roles: it acts as a filter for high-energy blue light, protecting the delicate retinal cells from phototoxic damage, and it serves as a potent antioxidant, neutralizing harmful reactive oxygen species that can cause oxidative stress in the eye. This dual action helps preserve the integrity and function of macular cells. Zeaxanthin is a fat-soluble compound, and its absorption is enhanced when consumed with dietary fats. OmniXan's natural form is believed to offer favorable bioavailability compared to synthetic alternatives, ensuring efficient delivery to ocular tissues.

Side effects

OmniXan, containing RR-zeaxanthin, is generally considered very safe and has been affirmed as Generally Recognized As Safe (GRAS) by an independent expert panel for use in foods and supplements. Common side effects are not well-documented, as zeaxanthin is typically well-tolerated. Uncommon side effects, occurring in 1-5% of users, may include rare, mild gastrointestinal discomfort, which has been reported with some carotenoid supplements. Significant rare side effects (less than 1%) have not been reported. There are no major known drug interactions with zeaxanthin. Contraindications are not established, but caution is advised for individuals with known hypersensitivity to carotenoids. While safety in pregnancy and lactation has not been fully established through specific studies, zeaxanthin is generally considered to pose a low risk due to its natural occurrence in the diet and its GRAS status.

Dosage

For eye health benefits, typical supplementation ranges from 2 to 10 mg/day of zeaxanthin. Clinical trials often utilize doses between 1-10 mg/day, frequently in combination with lutein. There is no established upper limit for zeaxanthin, and doses up to 20 mg/day have been safely used in research settings. To optimize absorption, OmniXan should be taken with meals that contain dietary fat, as zeaxanthin is fat-soluble. The natural RR-zeaxanthin found in OmniXan may offer better bioavailability compared to synthetic forms. Zeaxanthin is often co-administered with other antioxidants, such as vitamins C, E, and zinc, particularly in formulations aimed at managing age-related macular degeneration (AMD). Consistent daily intake over several months is necessary to observe benefits, as macular pigment accumulation is a gradual process.

FAQs

Is OmniXan safe?

Yes, OmniXan has been affirmed as Generally Recognized As Safe (GRAS) by an independent expert panel, indicating its safety for use in foods and supplements based on rigorous toxicological review.

How long before benefits appear?

Increases in macular pigment optical density (MPOD) and other eye health benefits typically require several months of consistent daily supplementation with OmniXan, as the accumulation of zeaxanthin in the macula is a gradual process.

Can it prevent AMD?

While zeaxanthin may help slow the progression of age-related macular degeneration (AMD) and support overall eye health, it does not cure AMD. Its benefits are modest and are best realized as part of a comprehensive eye health strategy.

Is it better than other zeaxanthin sources?

OmniXan is a natural RR-zeaxanthin, which may offer superior bioavailability compared to some synthetic forms. However, conclusive clinical superiority over other zeaxanthin sources has not been definitively established through comparative studies.

Research Sources

https://nutraceuticalbusinessreview.com/omniactive-omnixan-rr-zeaxanthin-from-natural-paprika-achieves-self-affirmed-gras-status-99608 – This source reports on OmniXan RR-zeaxanthin achieving self-affirmed GRAS (Generally Recognized As Safe) status. An independent expert panel reviewed the safety data, confirming its suitability for use in food and supplement applications, which is a key indicator of its safety profile.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7692753/ – This review summarizes findings from 26 clinical trials on carotenoid supplementation, including zeaxanthin. It indicates that carotenoids show protective effects in age-related macular degeneration (AMD) and cataract prevention, though some trials had mixed results regarding specific endpoints and formulations.
https://pubmed.ncbi.nlm.nih.gov/34157098/ – This systematic review and meta-analysis found that lutein/zeaxanthin intake significantly increased macular pigment optical density (MPOD). This supports the role of these carotenoids in eye health and provides strong evidence for their efficacy in improving a key biomarker for macular health.

Score: 73/100