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Omega 7

Also known as: Palmitoleic acid, Omega-7 fatty acid, cis-Palmitoleic acid, Vaccenic acid, Palmitoleic Acid

Overview

Omega-7 fatty acids, primarily palmitoleic acid, are monounsaturated fatty acids found in sources like macadamia nuts, sea buckthorn oil, and some fish oils. While less researched than omega-3s, they are being investigated for potential health benefits, particularly related to lipid metabolism and inflammation. Palmitoleic acid is a 16-carbon fatty acid with a single double bond. Research suggests potential benefits in improving lipid profiles, but the evidence base is still developing. Available evidence consists of small clinical trials and mechanistic studies. More extensive research is needed to fully understand their effects and optimal usage.

Benefits

The primary benefit of omega-7 fatty acids, specifically palmitoleic acid, is its potential to improve lipid profiles in individuals with dyslipidemia. A randomized controlled trial showed that supplementation with purified palmitoleic acid significantly reduced CRP, triglycerides, and LDL cholesterol while increasing HDL cholesterol. These effects were observed after 30 days of supplementation. However, other studies using mixed omega-7 fatty acids have not shown significant reductions in inflammatory biomarkers or improvements in quality of life. Therefore, the evidence is still emerging, and more research is needed to confirm these benefits.

How it works

Omega-7 fatty acids are thought to exert their effects primarily through lipid metabolism pathways. They may influence cholesterol and triglyceride levels by interacting with enzymes and receptors involved in lipid metabolism. While the specific molecular targets are not well-defined, it's believed that omega-7s can modulate lipid profiles, potentially impacting cardiovascular health. The absorption and bioavailability of omega-7 fatty acids are expected to be similar to other dietary fatty acids, but further research is needed to fully elucidate the mechanisms of action.

Side effects

Omega-7 fatty acids appear to be relatively safe based on the limited available studies. No common or uncommon side effects have been consistently reported in the literature. However, long-term safety data are lacking, and rare side effects cannot be ruled out. There is a potential for interactions with lipid-lowering medications, although this is speculative and requires further investigation. Caution is advised for individuals with specific lipid metabolism disorders. Pregnant or breastfeeding women should consult healthcare providers before using omega-7 supplements. Overall, more comprehensive safety studies are needed to fully characterize the side effect profile of omega-7 fatty acids.

Dosage

The minimum effective dose of omega-7 fatty acids is not well-established. One study used 220.5 mg of cis-palmitoleic acid per day with positive effects on lipid profiles. Optimal dosage ranges are not clearly defined, but doses up to 688 mg/day have been tested without significant adverse effects. The maximum safe dose is currently unknown. It is generally recommended to take fatty acid supplements with meals to enhance absorption. Omega-7 fatty acids are available in various forms, including supplements and natural food sources. No specific cofactors are identified as necessary for omega-7 fatty acid supplementation.

FAQs

Should I consult my doctor before taking omega-7 supplements?

Yes, it is advisable to consult with a healthcare provider before starting omega-7 supplements, especially if you are taking other medications or have existing health conditions.

Are omega-7 fatty acids safe for long-term use?

While generally considered safe, long-term safety data on omega-7 fatty acids are limited. More research is needed to fully assess the safety of long-term supplementation.

How should I take omega-7 supplements for best absorption?

It is recommended to take omega-7 supplements with meals to enhance absorption, similar to other fat-soluble nutrients.

What benefits can I expect from taking omega-7 supplements?

Potential benefits include improved lipid profiles, such as reduced triglycerides and LDL cholesterol, and increased HDL cholesterol, particularly in individuals with dyslipidemia.

Are omega-7 fatty acids the same as omega-3 fatty acids?

No, omega-7 fatty acids are distinct from omega-3 fatty acids. They have different chemical structures and may exert different effects in the body. Omega-7s are also less well-studied.

Research Sources

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654 – This randomized controlled trial investigated the effects of cis-palmitoleic acid on lipid profiles in adults with dyslipidemia and mild systemic inflammation. The study found that 220.5 mg of cis-palmitoleic acid daily for 30 days significantly reduced CRP, triglycerides, and LDL cholesterol, while increasing HDL cholesterol. The findings suggest a potential benefit of palmitoleic acid in improving lipid profiles.
https://pubmed.ncbi.nlm.nih.gov/34444963/ – This double-blind, placebo-controlled crossover trial tested the effects of mixed omega-7 fatty acids (688 mg/day) on inflammatory biomarkers and quality of life in individuals with musculoskeletal discomfort. The study found no significant effects on inflammatory biomarkers or quality of life. These results indicate that mixed omega-7 fatty acids may not provide significant benefits for inflammation or quality of life in this population.
https://pubmed.ncbi.nlm.nih.gov/37589276/ – This study investigates the impact of dietary supplementation with omega-3 and omega-7 fatty acids on lipid metabolism and intestinal health in high-fat diet-induced obese mice. The results suggest that omega-3 and omega-7 fatty acids can modulate lipid metabolism and improve intestinal health, potentially mitigating the adverse effects of a high-fat diet.
https://pubmed.ncbi.nlm.nih.gov/25499944/ – This study explores the effects of palmitoleic acid on metabolic inflammation and insulin resistance in skeletal muscle cells. The findings indicate that palmitoleic acid can reduce metabolic inflammation and improve insulin sensitivity in skeletal muscle cells, suggesting a potential role in managing insulin resistance.
https://pubmed.ncbi.nlm.nih.gov/34612056/ – This research investigates the impact of dietary supplementation with omega-7 palmitoleic acid on the gut microbiota and metabolic parameters in obese mice. The results suggest that omega-7 palmitoleic acid can modulate the gut microbiota composition and improve metabolic parameters in obese mice, indicating a potential role in managing obesity-related metabolic disorders.