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Muscle & Mitochondrial Energy Matrix

Also known as: arginine silicate inositol, nitrosigine, inositol-stabilized arginine silicate, Nitrosigine

Overview

Nitrosigine is a patented, inositol-stabilized compound that combines arginine and silicate, primarily designed to enhance nitric oxide (NO) levels in the body. This increase in NO is linked to improved blood flow and energy levels, particularly during physical activity, making it a popular ingredient in supplements for athletes and bodybuilders. Nitrosigine is noted for its greater stability and bioavailability compared to traditional arginine hydrochloride, which contributes to its effectiveness. Research demonstrates moderate to high quality evidence supporting its use in reducing muscle damage and enhancing perceived energy, bolstered by various preclinical and human clinical trials. It is commonly available in powdered supplement forms and is often consumed before workouts to maximize workout performance.

Benefits

Nitrosigine offers several scientifically-backed benefits: 1. Enhanced vasodilation and hyperemia, which lead to improved blood flow and nutrient delivery to muscles during exercise. 2. Increased perceived energy levels, with significant boosts noted in studies following supplementation. 3. Reduction in markers of muscle damage post-exercise, aiding in recovery. Notably, in a controlled study, a dosage of 1.5g led to significant improvements in energy perception and reductions in damage markers compared to placebo groups. These benefits are particularly pronounced in performance-oriented populations, indicating its utility in sports and fitness contexts.

How it works

Nitrosigine functions by stabilizing arginine, which enhances its conversion into nitric oxide through the action of nitric oxide synthase. This conversion promotes vasodilation, resulting in increased blood flow. Improved blood flow is crucial for athletes as it enables better delivery of oxygen and nutrients to muscles during exercise. Additionally, the enhanced oxygenation can help minimize muscle damage, thus contributing to improved performance and recovery during intense physical activity.

Side effects

Nitrosigine is considered generally safe, with minimal side effects reported. The most common issue, though not well-documented, is mild gastrointestinal discomfort. Overall, serious or rare adverse effects have not been observed in clinical trials. There are no known drug interactions or contraindications associated with Nitrosigine, making it suitable for a broad range of users. However, it is advisable for individuals with particular health conditions or those on medication to consult a healthcare professional prior to starting any new supplement regimen.

Dosage

The recommended dosage for Nitrosigine is between 1.5 and 2 grams per day, ideally taken 30 to 60 minutes before exercise to achieve maximum effects. This dosage range has shown to effectively increase performance and energy without reported safety concerns. While no upper limit has been definitively established, higher doses above 2 grams have not been extensively studied. For optimal absorption, it is recommended to take Nitrosigine on an empty stomach, but specific form-related recommendations beyond the inositol-stabilized variant are unnecessary.