Neurofactor Coffea Arabica Fruit Extract
Also known as: NeuroFactor, CognatiQ, Whole Coffee Fruit Concentrate (WCFC), Coffea arabica fruit extract
Overview
Coffea arabica fruit extract, often marketed as NeuroFactor or CognatiQ, is a patented extract derived from the fruit of the *Coffea arabica* plant. This extract is used as a dietary supplement to support brain health, cognitive function, and neuroprotection. It is rich in polyphenols, particularly chlorogenic acid, and other phytonutrients that stimulate the production of Brain-Derived Neurotrophic Factor (BDNF). BDNF is crucial for the development, maintenance, and repair of neurons. The extract is orally bioavailable, with significant increases in BDNF observed within 60 minutes of ingestion. While traditionally the coffee fruit was discarded, it has been rediscovered for its health benefits. Research is primarily based on a few clinical studies and pilot trials, indicating a need for larger, more diverse studies to confirm its benefits and safety.
Benefits
NeuroFactor's primary benefit is its ability to significantly increase BDNF levels. Studies have shown that a 100mg dose can increase plasma BDNF by as much as 91% at 60 minutes and 66% at 120 minutes compared to baseline. Another study reported a 143% increase in BDNF levels compared to baseline, with effects lasting for at least two hours. Secondary benefits include antioxidant effects, which help protect against oxidative stress and inflammation. Some studies suggest it may improve cognitive performance, including memory and focus, although these effects are less quantitatively defined. These benefits have been primarily observed in healthy human subjects, and more research is needed to determine its effectiveness in other populations, such as those with neurodegenerative diseases. The effect sizes for BDNF increase are substantial, suggesting potential clinical significance for neuroprotection and cognitive function.
How it works
NeuroFactor stimulates the production of BDNF, a neuroprotein essential for the development, maintenance, and repair of neurons. The unique polyphenol profile in coffee fruit is responsible for this effect. BDNF plays a critical role in the central nervous system, affecting brain health and cognitive functions. NeuroFactor increases BDNF levels in the blood and in exosomes, which can cross the blood-brain barrier. The polyphenols, particularly chlorogenic acid, in NeuroFactor interact with cellular pathways to stimulate BDNF release from various mammalian cells, though the exact mechanisms and cell types involved are not fully elucidated. The extract is orally bioavailable, with significant increases in BDNF observed within 60 minutes of ingestion.
Side effects
The available studies suggest that NeuroFactor is generally safe when used as directed. There are no reported common side effects in the available studies. No specific uncommon or rare side effects have been documented due to the limited scope of current research. There are no known significant drug interactions, but caution should be exercised when combining with other supplements or medications without medical advice. No specific contraindications have been identified, but as with any supplement, individuals with underlying health conditions or pregnant/breastfeeding women should consult a healthcare provider. More research is needed to determine safety and efficacy in special populations such as children, the elderly, or those with chronic diseases. Long-term safety data are limited, so caution is advised.
Dosage
The minimum effective dose of NeuroFactor appears to be 100mg, as this dose has been shown to significantly increase BDNF levels in clinical studies. The optimal dosage range is not fully established, but 100mg per day is the commonly recommended dose based on available studies. There is no established maximum safe dose, but doses up to 100mg have been used without reported adverse effects. It can be taken at any time, but some users prefer taking it in the morning or before cognitive tasks. It can be added to beverages, pills, or other supplements. The absorption is facilitated by the oral route, with significant effects observed within 60 minutes. There are no known required cofactors for the efficacy of NeuroFactor.
FAQs
Can NeuroFactor be combined with other supplements or caffeinated substances?
Yes, NeuroFactor can be combined with other supplements or caffeinated substances due to its low caffeine content (0.7%). It is suitable for individuals sensitive to caffeine as it does not act as a stimulant.
Is NeuroFactor safe?
NeuroFactor is generally considered safe based on current data, but long-term safety and interactions need further study. Consult with a healthcare provider if you have underlying health conditions.
When is the best time to take NeuroFactor?
NeuroFactor can be taken at any time, but it is often used in the morning or before cognitive tasks. It has been shown to increase BDNF levels within 60 minutes of ingestion.
What results can I expect from taking NeuroFactor?
You can expect a significant increase in BDNF levels within 60 minutes, with potential cognitive benefits over time. Individual results may vary, and further research is ongoing.
How is NeuroFactor different from regular coffee?
Unlike brewed coffee or green coffee extracts, NeuroFactor specifically increases BDNF levels due to its unique polyphenol profile. It is derived from the whole fruit of the *Coffea arabica* plant.
Research Sources
- https://west.supplysideshow.com/content/dam/Informa/westsupplysideshow/sposnorshipassets/Neurofactor%20flyer.pdf – This flyer highlights that NeuroFactor is derived from the whole fruit of the coffee plant and has been clinically shown to increase BDNF, which is vital for learning, memory, and higher thinking. It emphasizes that NeuroFactor is a natural ingredient that supports cognitive health and is suitable for various applications in the supplement and food industries.
- https://hitoshin.com/blog/neurofactor-benefits/ – This blog post discusses the potential benefits of NeuroFactor, including its ability to boost BDNF levels and improve cognitive functions. It suggests that NeuroFactor can enhance memory, focus, and overall brain health, making it a valuable supplement for those looking to support their cognitive performance.
- https://www.scirp.org/journal/paperinformation?paperid=36447 – This study investigates the effects of whole coffee fruit concentrate (WCFC) on BDNF levels. The results indicate that a 100mg dose of WCFC significantly increased plasma BDNF levels within 60 minutes, suggesting a potential mechanism for cognitive enhancement through BDNF modulation.
- https://www.futureceuticals.com/cognatiq – This resource details that CognatiQ, formerly known as NeuroFactor, is a clinically studied ingredient shown to increase BDNF and support cognitive function. It highlights that CognatiQ can improve cognitive task completion times and is suitable for use in various cognitive health products.
- https://www.mdpi.com/2076-3921/13/1/10 – This review article discusses the potential health benefits of coffee consumption, including its impact on cognitive function and neuroprotection. It highlights the role of coffee's bioactive compounds, such as polyphenols, in modulating brain health and reducing the risk of neurodegenerative diseases, providing context for the potential benefits of NeuroFactor.