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Nattozimes Proprietary Blend

Q: Is nattokinase safe?

Nattokinase is generally considered safe, but individuals with bleeding disorders or those on anticoagulants should use caution.

Q: When should I take nattokinase?

Nattokinase can be taken orally at any time, although no specific timing recommendations exist.

Q: What benefits can I expect?

Users may experience reductions in blood pressure and improvements in lipid profiles, although lipid effects can be dose-dependent.

Q: Can I use nattokinase as a substitute for medication?

No, nattokinase should not replace prescribed medications; it is best used as a supplementary therapy for cardiovascular health.

Also known as: Nattokinase, natto kinase, subtilisin NAT

Overview

Nattokinase is a fibrinolytic enzyme derived from the fermentation of soybeans by the bacterium *Bacillus subtilis* var. *natto*. It is recognized for its ability to break down fibrin, a protein that plays a vital role in blood clot formation. As a dietary supplement, nattokinase is primarily employed to support cardiovascular health, with research suggesting it may help lower blood pressure and improve lipid profiles. The enzyme has gained attention for its potential role in enhancing blood flow and preventing cardiovascular diseases. Current research includes several randomized controlled trials and meta-analyses that demonstrate its significant effects on various cardiovascular risk factors, indicating a high level of evidence supporting its benefits when used appropriately.

Benefits

Nattokinase supplementation has been linked to several important cardiovascular benefits: 1) Blood Pressure: Significant reductions have been observed in systolic (MD = -3.45) and diastolic (MD = -2.32) blood pressure, indicating a clinically relevant effect (p < 0.00001). 2) Blood Lipids: Low doses reduced total cholesterol (MD = 5.27) and high-density lipoprotein cholesterol (MD = -2.76), though high doses increased total cholesterol (p < 0.00001). 3) Blood Glucose: A slight increase in blood glucose was reported (MD = 0.40, p < 0.0001). Overall, evidence suggests that the greatest benefits are seen in adults with cardiovascular risk factors, with clinically significant outcomes noted over various durations of supplementation.

How it works

Nattokinase exerts its fibrinolytic effects by degrading fibrin and other proteins involved in clot formation. This action aids in the maintenance of healthy blood flow, consequently reducing blood pressure and modulating lipid profiles. Its primary molecular target is fibrin, leading to preventing thrombus formation. While the details of its absorption and bioavailability remain limited, its efficacy is apparent from clinical studies indicating beneficial cardiovascular effects following oral administration.

Side effects

Nattokinase appears to have a favorable safety profile, with no adverse events reported in clinical studies analyzed. Common side effects (>5%) have not been documented, and uncommon (1-5%) and rare (<1%) side effects also remain unreported. However, caution is advisable in individuals taking anticoagulant medications due to its fibrinolytic properties, and those with bleeding disorders should avoid its use altogether. Contraindications include individuals with specific medical conditions or on certain medications, particularly anticoagulants. Pregnant or breastfeeding women should consult healthcare providers to ensure safety.

Dosage

The minimum effective dose of nattokinase is not well-defined, but clinical effects were noted at dosages ranging from 1200 to 8000 fibrin units (FU). The optimal dosage varies, with evidence indicating that lower doses may have differing effects on lipid profiles compared to higher doses. Although no maximum safe dose has been established, no adverse events have been reported in studies. Nattokinase is generally administered orally, and specifics on timing are not provided. The enzyme is primarily available in capsule form, and factors influencing absorption are not detailed, while there are no known cofactors necessary for supplementation.

FAQs

Is nattokinase safe?

Nattokinase is generally considered safe, but individuals with bleeding disorders or those on anticoagulants should use caution.

When should I take nattokinase?

Nattokinase can be taken orally at any time, although no specific timing recommendations exist.

What benefits can I expect?

Users may experience reductions in blood pressure and improvements in lipid profiles, although lipid effects can be dose-dependent.

Can I use nattokinase as a substitute for medication?

No, nattokinase should not replace prescribed medications; it is best used as a supplementary therapy for cardiovascular health.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/39076715/ – This systematic review and meta-analysis evaluated the cardiovascular impacts of nattokinase, finding significant reductions in both systolic and diastolic blood pressure, alongside mixed effects on lipid profiles based on dosage. Limitations include heterogeneous outcomes across studies.
https://hsls.libguides.com/PubMed-search-filters/systematic-reviews – The review emphasizes effective search methodologies in literature, particularly for systematic reviews on interventions like nattokinase, enhancing the understanding of its cardiovascular benefits.
https://article.imrpress.com/journal/RCM/24/8/10.31083/j.rcm2408234/f4528db16e9639db9e2a042e810bc7b2.pdf – This research article provides in-depth examination of nattokinase's pharmacological effects, outlining its mechanisms of action in fibrinolysis and potential implications for cardiovascular health.
https://www.mdpi.com/2076-3921/11/8/1419 – This peer-reviewed article discusses the biochemical properties of nattokinase and reports on clinical evidence supporting its cardiovascular protection, solidifying its potential therapeutic roles.