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Nad3 Proprietary Blend

Also known as: Theacrine, Wasabia japonica, Copper (I) Niacin Chelate, Japanese Horseradish, NAD3 Proprietary Blend

Overview

NAD3 Proprietary Blend is designed to enhance cellular energy and support metabolism by improving nicotinamide adenine dinucleotide (NAD+) levels. This blend primarily consists of theacrine, a stimulant closely related to caffeine, Wasabia japonica (Japanese horseradish) standardized for isothiocyanates, and copper (I) niacin chelate. Theacrine is naturally found in certain tea plants, while Wasabia japonica is renowned for its health benefits and its native origins in Japan. The combination in NAD3 aims to improve lipid metabolism and NAD+ production, both crucial for energy metabolism. While the blend has shown potential benefits in early studies, research maturity is limited as the available evidence primarily comes from small-scale human trials, hence further investigation is essential to establish effectiveness and safety.

Benefits

NAD3 has shown several evidence-based benefits, particularly in lipid metabolism. A study demonstrated significant reductions in total cholesterol (11.1%), LDL cholesterol (15.2%), and LDL:HDL ratio (18.9%) over a 12-week supplementation period. Improvements in NAD+/NADH ratios were also observed, suggesting enhanced cellular energy status. These benefits appear particularly relevant for populations with dyslipidemia or those aiming to improve lipid profiles and overall metabolic health. Effect sizes for the lipid improvements are considered moderate to significant, although comprehensive studies are required to validate clinical significance across different demographic groups.

How it works

The NAD3 blend likely impacts lipid metabolism and enhances NAD+ biosynthesis through its components. Theacrine is believed to act on adenosine receptors, which play a role in energy metabolism, while copper (I) niacin chelate may influence enzymes important for NAD+ synthesis. By targeting these biological pathways, NAD3 can potentially improve cardiovascular health through favorable lipid profile adjustments and promote optimized cellular metabolism by enhancing NAD+ availability.

Side effects

Currently, the safety profile of NAD3 is considered generally favorable, but long-term effects remain unknown due to limited data. Common side effects have not been extensively documented, with few studies reporting adverse events. Uncommon side effects may exist but are largely unidentified due to a lack of comprehensive safety evaluations. There have been no reported rare side effects in available studies. Caution is advised for individuals with sensitive cardiovascular conditions, and potential interactions with medications affecting lipid metabolism or adenosine receptors are speculated but not well-studied. Pregnant or breastfeeding individuals are advised to consult healthcare professionals prior to use due to insufficient safety data.

Dosage

The minimum effective dose for NAD3, based on existing research, is 312 mg of the proprietary blend per day. However, optimal dosages have not been firmly established due to the limited scope of studies conducted. Maximum safe dosage remains undetermined, and no specific timing or administration recommendations have been established for this blend. Common forms of NAD3 include capsules or tablets, yet specific absorption factors have not been identified, highlighting the need for further investigation into the pharmacokinetics of the blend.

FAQs

Is NAD3 safe for everyone?

While generally considered safe, individuals with cardiovascular conditions should consult a healthcare provider before use due to limited long-term safety data.

How long does it take to see results with NAD3?

Initial benefits in lipid profiles were observed after 12 weeks of supplementation, but results may vary among individuals.

Can I take NAD3 with other supplements?

There could be potential interactions with medications that impact lipid metabolism or adenosine receptors; it's best to consult a healthcare provider.

What are the expected benefits of NAD3?

Users can expect improvements in lipid profiles and enhanced cellular energy status based on preliminary research findings.

Is NAD3 the same as other NAD+ supplements?

No, NAD3 is not a direct NAD+ supplement; it supports NAD+ levels through its unique blend of components.

Research Sources

https://www.mdpi.com/2673-9488/2/1/2 – This study evaluated the effects of NAD3 over 12 weeks, reporting significant enhancements in lipid profiles and cellular energy metrics among participants, while noting the small sample size as a limitation.
https://pubmed.ncbi.nlm.nih.gov/35303905/ – This meta-analysis aggregated data from numerous studies regarding NAD+ precursors, indicating overall improvements in lipid profiles but flagging hyperglycemia as a potential side effect, though it did not focus specifically on NAD3.
https://archive.hshsl.umaryland.edu/bitstream/handle/10713/15463/NAD_Final_2021_02.pdf?sequence=4 – This comprehensive review highlighted the impact of NAD+ and its precursors on various metabolic functions, while emphasizing the need for targeted research on proprietary blends like NAD3.
https://www.researchgate.net/publication/359396408_Enhance_Trial_Effects_of_NAD3R_on_Hallmarks_of_Aging_and_Clinical_Endpoints_of_Health_in_Middle_Aged_Adults_A_Subset_Analysis_Focused_on_Blood_Cell_NAD_Concentrations_and_Lipid_Metabolism – This explore subset analysis from an overarching trial indicated positive outcomes associated with NAD3, particularly relating to lipid metabolism and potential implications for aging-related health markers.