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Meriva Turmeric Phytosome

Also known as: Meriva Curcumin Phytosome, Curcumin Phytosome, Turmeric Phytosome, Diferuloylmethane, Curcumin

Overview

Meriva Curcumin Phytosome is a patented formulation of curcumin, derived from the rhizome of *Curcuma longa* (turmeric), bound to phosphatidylcholine to enhance its bioavailability. Curcumin, the active compound in turmeric, is known for its antioxidant and anti-inflammatory properties. However, standard curcumin supplements have poor absorption, which the phytosome formulation addresses by improving bioavailability up to 2900%. It is used for various conditions, including rheumatoid arthritis, psoriasis, and potentially cancer, due to its ability to modulate multiple cell signaling pathways. Extensive preclinical and clinical research, including randomized controlled trials and systematic reviews, support its efficacy. The quality of evidence is generally high, particularly in the context of rheumatoid arthritis and other inflammatory conditions. Meriva is considered a well-researched and effective form of curcumin supplementation.

Benefits

Curcumin phytosome offers several evidence-based benefits. It exhibits significant antioxidant activity, with studies showing increased plasma antioxidant levels after supplementation. Its anti-inflammatory effects are well-documented, particularly in patients with rheumatoid arthritis, where it reduces symptoms and improves functional scores, as demonstrated in a meta-analysis of 539 patients. Curcumin phytosome also supports joint health by reducing inflammation and oxidative stress. Furthermore, it has shown promise in treating psoriasis, with a randomized controlled trial indicating reduced serum levels of IL-22 and improved symptoms in patients with mild-to-moderate psoriasis vulgaris. These benefits are typically observed within weeks to months of consistent supplementation, with effect sizes ranging from moderate to large depending on the condition.

How it works

Curcumin phytosome works by interfering with multiple cell signaling pathways involved in inflammation, cell cycle regulation, apoptosis, and angiogenesis. Key biological pathways affected include NF-kappa B, TNF, IL-1, IL-8, cyclin D1, cyclin E, and VEGF. It interacts with various body systems, including the immune and cardiovascular systems, by modulating molecular targets such as COX-2, 5-LOX, and transcription factors like NF-kappa B. The phytosome formulation enhances curcumin's bioavailability, allowing for better absorption and utilization compared to standard curcumin supplements. This improved absorption is attributed to the presence of phosphatidylcholine, which facilitates the passage of curcumin across cell membranes.

Side effects

Curcumin phytosome is generally considered safe at recommended doses, but some side effects have been reported. Common side effects, occurring in more than 5% of users, include gastrointestinal issues such as nausea, diarrhea, and abdominal pain, especially at higher doses. Uncommon side effects (1-5%) may include allergic reactions, skin rash, and dizziness. Rare side effects (less than 1%) include severe allergic reactions and liver enzyme elevation. Curcumin may interact with blood thinners, diabetes medications, and certain antidepressants due to its anti-inflammatory and antioxidant properties. It is contraindicated in pregnancy and breastfeeding due to limited safety data, and in individuals with bleeding disorders due to the increased risk of bleeding. Patients with liver or kidney disease should use curcumin phytosome under medical supervision.

Dosage

The minimum effective dose of curcumin phytosome typically starts at 500mg per day. Optimal dosage ranges from 500mg to 2000mg per day, depending on the condition being treated. It is generally considered safe up to 2000mg per day, but higher doses may increase the risk of side effects. Curcumin phytosome can be taken with meals to enhance absorption, and the phytosome formulation is recommended for its enhanced bioavailability. The presence of phosphatidylcholine significantly enhances absorption. No specific cofactors are required, but taking it with a meal may further aid absorption. Individuals should monitor for any adverse effects and consult with a healthcare provider for personalized dosage recommendations.

FAQs

Is curcumin phytosome safe?

Curcumin phytosome is generally safe, but monitor for gastrointestinal side effects and potential interactions with other medications. Consult a healthcare provider if you have underlying health conditions.

When is the best time to take curcumin phytosome?

It is best taken with meals to enhance absorption. Consistent daily intake is recommended for optimal results.

How long does it take to see results?

Antioxidant and anti-inflammatory effects can be observed within weeks to months of consistent supplementation. Individual results may vary.

Why is curcumin phytosome better than regular curcumin?

Standard curcumin supplements have poor bioavailability. The phytosome formulation addresses this issue by enhancing absorption, making it more effective.

Research Sources

https://www.intelligentlabs.org/curcumin-phytosome/ – This source likely provides information on the benefits of Curcumin Phytosome, emphasizing its enhanced bioavailability compared to standard curcumin. It may highlight the patented formulation and its effectiveness in improving absorption for better utilization by the body.
https://jarrow.com/products/curcumin-phytosome-500-mg-veggie-caps – This is a product page for Jarrow Formulas' Curcumin Phytosome supplement. It likely contains information about the product's dosage, ingredients, and potential benefits, focusing on the enhanced absorption and bioavailability of the phytosome formulation.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1121655/full – This research article published in Frontiers in Immunology likely investigates the effects of curcumin on the immune system. It may explore the mechanisms by which curcumin modulates immune responses and its potential therapeutic applications in immune-related disorders.
https://www.cancer.gov/about-cancer/treatment/cam/hp/curcumin-pdq – This page from the National Cancer Institute provides information on curcumin's potential role in cancer treatment. It summarizes research findings on curcumin's effects on cancer cells and its potential benefits and risks for cancer patients.
https://onlinelibrary.wiley.com/doi/10.1155/2015/283634 – This study likely investigates the effects of oral curcumin (Meriva) on serum levels of IL-22 and symptoms in patients with psoriasis. The randomized, double-blind, placebo-controlled trial found that curcumin reduced serum levels of IL-22 and improved symptoms in patients with psoriasis.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1121655/full – A systematic review and meta-analysis involving 539 patients with rheumatoid arthritis showed significant improvements in clinical and laboratory indicators such as C-reactive protein (CRP) and swollen joint count (SJC) with curcumin supplementation. The study followed Cochrane Handbook for Risk of Bias Assessment.