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Melitidin

Also known as: Melitidin, Bergamot flavonoids, Bergamot polyphenols

Overview

Melitidin is a flavonoid compound found in bergamot (*Citrus bergamia*), a citrus fruit native to southern Italy. As a flavonoid, it is known for its antioxidant properties. While research on melitidin specifically is limited, it is often studied in the context of bergamot extracts, which are used for their potential to improve lipid profiles and cardiovascular health. Bergamot extracts containing melitidin are primarily used to reduce total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. These extracts are available in various forms, including capsules and tablets, and are typically well-tolerated. The benefits are generally observed in adults with hypercholesterolemia, with improvements typically seen within 30 days to 12 weeks of supplementation. Most evidence comes from studies on bergamot polyphenols, which include melitidin.

Benefits

Bergamot extracts, which contain melitidin, have demonstrated potential benefits in improving lipid profiles. Studies indicate a significant reduction in total cholesterol (approximately 63.60 mg/dL) and LDL cholesterol (about 55.43 mg/dL) with bergamot supplementation. Additionally, bergamot extracts may increase HDL cholesterol levels. These benefits are primarily observed in adults with hypercholesterolemia. Flavonoids like melitidin may also offer antioxidant and anti-inflammatory effects, though this is more general to flavonoids rather than melitidin specifically. Benefits are typically observed within 30 days to 12 weeks of supplementation.

How it works

Melitidin, as part of bergamot extracts, may improve lipid profiles and glucose homeostasis by activating AMPK (AMP-activated protein kinase). This activation influences the cardiovascular and metabolic systems. While the specific bioavailability of melitidin is not well-studied, flavonoids generally have variable absorption rates. The interaction with AMPK is a key mechanism through which bergamot flavonoids exert their beneficial effects on metabolic health. Further research is needed to fully elucidate the specific mechanisms of action for melitidin.

Side effects

Bergamot extracts, which contain melitidin, are generally well-tolerated in clinical studies. There is limited data on common side effects specifically for melitidin, but bergamot extracts are typically considered safe. Potential side effects are not well-documented for melitidin. As a precaution, individuals taking medications affecting lipid metabolism or blood sugar control should consult with a healthcare provider due to potential interactions. Pregnant or breastfeeding women should also seek medical advice before using any supplements containing bergamot extracts or melitidin. Individual reactions can vary, so monitoring for any adverse effects is advisable.

Dosage

While a minimum effective dose and maximum safe dose have not been established specifically for melitidin, bergamot extracts are often used in the range of 500-1000 mg per day. These extracts are typically taken once or twice daily, often available as capsules or tablets. Bioavailability may be influenced by food intake, so taking the supplement with meals may enhance absorption. Consult with a healthcare provider before starting any supplement regimen to determine the appropriate dosage and ensure safety. More research is needed to determine specific dosage recommendations for melitidin.

FAQs

What is melitidin?

Melitidin is a flavonoid compound found in bergamot, a citrus fruit. It's often studied as part of bergamot extracts for potential health benefits.

How should I take bergamot extract containing melitidin?

It is typically taken with meals to enhance absorption. Consult a healthcare provider before starting any supplement regimen.

What are the expected results from taking bergamot extract?

Potential improvements in lipid profiles may be observed within weeks of consistent use. Individual results can vary.

Is bergamot extract safe?

Bergamot extracts are generally considered safe, but individual reactions can vary. Consult a healthcare provider before use, especially if you have existing health conditions or are taking medications.

What is the correct dosage of bergamot extract?

Bergamot extracts are often used in the range of 500-1000 mg per day, but consult a healthcare provider for personalized advice.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6497409/ – This study reviews the potential of bergamot extracts to improve cardiovascular health through antioxidant and metabolic pathways. It highlights that bergamot extracts are generally well-tolerated and may offer benefits for individuals looking to improve their lipid profiles. The review provides a comprehensive overview of bergamot's health benefits, though it does not specifically focus on melitidin.
https://pubmed.ncbi.nlm.nih.gov/37307278/ – This study investigates the effects of bergamot supplementation on lipid profiles. The systematic review and meta-analysis included fourteen trials involving adults with hypercholesterolemia. The key finding was that bergamot supplementation significantly reduced total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, supporting the use of bergamot extracts for lipid profile improvement.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.7647 – This study examines the impact of bergamot polyphenol fractions on lipid profiles and glucose levels in adults with hyperlipidemia. The randomized, double-blind, placebo-controlled trial found that bergamot polyphenol fractions improved lipid profiles and glucose levels over a 30-day period. While the study did not specifically isolate melitidin's effects, it provides evidence for the benefits of bergamot extracts.
https://www.tandfonline.com/doi/pdf/10.1080/10408398.2019.1677554 – This research provides a comprehensive overview of bergamot's health benefits, including its potential to improve cardiovascular health through antioxidant and metabolic pathways. It highlights that bergamot extracts are generally well-tolerated and may offer benefits for individuals looking to improve their lipid profiles. The review provides a comprehensive overview of bergamot's health benefits, though it does not specifically focus on melitidin.
https://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0011382 – This article discusses the use of bergamot in the context of neglected tropical diseases. While it does not directly relate to the lipid-lowering or cardiovascular benefits of bergamot, it highlights the diverse applications and research areas associated with this citrus fruit. The article provides a broader perspective on the potential uses of bergamot beyond its well-known effects on cholesterol levels.