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Mediator 50p

Also known as: Phosphatidic Acid, PA, Mediator 50p

Overview

Phosphatidic acid (PA) is a phospholipid found in cell membranes, particularly in muscle cells, where it plays a crucial role as a signaling lipid. Mediator 50p is a branded form of PA used as a dietary supplement to enhance muscle mass, strength, and recovery. It works by activating the mammalian target of rapamycin (mTOR) pathway, a key regulator of muscle protein synthesis. PA is amphiphilic, allowing for efficient oral absorption, and is available in various supplement forms like capsules, powders, and bars. Research suggests that PA supplementation, when combined with resistance training and adequate protein intake, can lead to significant improvements in muscle growth and strength. While studies specifically on Mediator 50p are limited, the existing evidence from randomized controlled trials (RCTs) and systematic reviews on PA and related protein supplementation supports its efficacy in promoting muscle hypertrophy.

Benefits

Phosphatidic acid (PA), particularly in the form of Mediator 50p, offers several benefits when combined with resistance training. Primarily, it increases lean muscle mass and strength gains. Studies have shown a 3-4% increase in squat strength compared to placebo after 8 weeks of PA supplementation alongside training. PA enhances muscle protein synthesis pathways, promoting muscle hypertrophy. Secondary benefits include supporting fat loss and body recomposition, as well as potentially reducing muscle breakdown and improving recovery post-exercise. Healthy adults engaged in resistance exercise benefit most, especially those aiming to increase muscle size and strength. These benefits are typically observed within 6-8 weeks of consistent supplementation.

How it works

Phosphatidic acid (PA) functions primarily by activating the mammalian target of rapamycin (mTOR) pathway, a critical regulator of muscle protein synthesis. As a signaling lipid, PA directly influences mTOR complex 1 (mTORC1), enhancing anabolic signaling within skeletal muscle cells. This activation promotes protein synthesis, leading to muscle hypertrophy. PA's amphiphilic nature facilitates its absorption and bioavailability, allowing it to efficiently interact with cellular pathways. The synergistic effect with protein intake further amplifies the muscle anabolic response, making PA an effective supplement for enhancing muscle growth and strength.

Side effects

Phosphatidic acid (PA), including Mediator 50p, is generally well-tolerated with a favorable safety profile. Clinical trials have not reported any significant adverse events associated with PA supplementation. Common side effects (occurring in more than 5% of users) have not been reported in referenced RCTs. Similarly, uncommon (1-5%) and rare (less than 1%) side effects are not documented in the available literature. No significant drug interactions have been reported. There are no established contraindications, although caution is advised for individuals with unknown sensitivities. Limited data exists for elderly individuals, children, or clinical populations, as studies have primarily focused on healthy adults. Overall, PA appears to be safe for consumption within recommended dosages.

Dosage

The minimum effective dose of phosphatidic acid (PA) is approximately 375 mg per day, as used in several RCTs. Optimal dosage ranges are between 250-375 mg daily, which have demonstrated effectiveness in studies. The maximum safe dose is not definitively established, but studies have used up to 375 mg/day without significant adverse effects. It is recommended to take PA within an hour of resistance training or with a protein source to maximize synergistic effects. PA can be consumed in capsule, powder, or bar form. Its amphiphilic nature aids absorption, and co-ingestion with protein may further enhance the muscle anabolic response. Adequate protein intake and consistent resistance exercise are necessary to realize the full benefits of PA supplementation.

FAQs

Is Mediator 50p safe?

Yes, clinical trials report good tolerability with no significant side effects at recommended dosages. However, individuals with pre-existing conditions should consult a healthcare professional before use.

When should I take it?

Ideally, consume PA within an hour of resistance training or with protein-containing meals to maximize its impact on muscle protein synthesis.

How soon will I see results?

Noticeable strength and muscle mass improvements typically appear after 6–8 weeks of consistent supplementation combined with resistance training.

Does it work without exercise?

No, the benefits of PA are contingent on concurrent resistance training and adequate protein intake to stimulate muscle protein synthesis.

Is it better than other muscle supplements?

PA targets mTOR signaling directly, a distinct mechanism compared to typical protein or creatine supplements, potentially offering additive effects when combined with these supplements.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC4974867/ – This double-blind RCT (n=28) examined the effects of 375 mg or 250 mg of phosphatidic acid (PA) versus placebo over 8 weeks of resistance training in healthy adults. The study found a 3.4% increase in squat strength over placebo with 375 mg PA, along with increased lean mass gains, and reported no adverse effects, suggesting PA's efficacy in enhancing muscle strength and size when combined with resistance training.
https://pubmed.ncbi.nlm.nih.gov/28698222/ – This meta-analysis of RCTs assessed the effects of protein supplementation on muscle strength and size during resistance training. The findings indicated that protein supplementation significantly enhances muscle hypertrophy and strength gains, supporting the importance of adequate protein intake alongside PA supplementation for optimal muscle growth.
https://www.e-epih.org/journal/view.php?number=1496 – This systematic review and meta-analysis evaluated the combined effects of protein supplementation and resistance exercise on muscle outcomes. The study confirmed synergistic effects on muscle mass and strength, reinforcing the necessity of protein intake with PA supplementation for optimal results, highlighting the importance of combined nutritional and exercise interventions.
https://cheminutra.com/ingredients/mediator/ – This source provides information on Mediator 50P, a specific form of phosphatidic acid. It highlights its role in activating the mTOR pathway, which is crucial for muscle protein synthesis, and emphasizes its potential to enhance muscle growth and strength when combined with resistance training.
https://nutrabio.com/products/phosphatidic-acid-mediator-500mg – This source describes phosphatidic acid (Mediator 500mg) as a supplement designed to enhance muscle protein synthesis and promote muscle growth. It emphasizes the importance of combining PA supplementation with resistance training and a proper diet to maximize its benefits on muscle strength and size.