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Maritime Pine Extract

Also known as: Pinus pinaster, Maritime Pine Extract, French Maritime Pine Extract, Pycnogenol, Pinus pinaster Extract

Overview

Maritime pine extract, often recognized by the trademarked name Pycnogenol, is derived from the bark of the *Pinus pinaster* tree, predominantly grown in southwest France. This extract is rich in flavonoids and is utilized as a herbal supplement for its antioxidant, anti-inflammatory, and circulatory benefits. Primary uses include improving circulation, reducing inflammation, and potentially alleviating symptoms of conditions like asthma and osteoarthritis. It is available in various forms, including capsules and tablets. Research on maritime pine extract is moderately mature, with several systematic reviews and meta-analyses available, though the quality of evidence varies across different applications. It is considered relatively safe when used appropriately, but awareness of potential side effects and interactions is important.

Benefits

Maritime pine extract offers several evidence-based benefits. It has demonstrated anti-inflammatory effects by reducing C-reactive protein (CRP) levels; a meta-analysis reported a significant reduction in CRP (-1.22 mg/dL, 95% CI: -2.43, -0.003). It may also improve circulation and alleviate symptoms of chronic venous insufficiency, such as leg pain and swelling. Additionally, some studies suggest that it can decrease asthma symptoms and reduce the need for rescue inhalers when used alongside conventional medications. Furthermore, there is evidence indicating that it might improve knee osteoarthritis symptoms and reduce pain medication use. These benefits are most pronounced in individuals with chronic inflammation, asthma patients, and those suffering from osteoarthritis.

How it works

Maritime pine extract works primarily through its antioxidant and anti-inflammatory actions. It modulates inflammatory responses and improves vascular function, interacting with various body systems. The extract contains procyanidins, which scavenge free radicals, reducing oxidative stress. It also influences the production of inflammatory mediators, such as cytokines, thereby reducing inflammation. The absorption and bioavailability of the extract are generally good, allowing it to exert its effects systemically. Specific molecular targets include enzymes involved in inflammation and oxidative stress pathways.

Side effects

Maritime pine extract is generally considered safe when used appropriately. Common side effects are mild and primarily involve gastrointestinal issues. Uncommon side effects include allergic reactions. Rare side effects are not well-documented. It may interact with anticoagulants due to its antiplatelet effects, increasing the risk of bleeding. It is contraindicated in pregnancy and breastfeeding due to insufficient safety data. Caution is advised in individuals with bleeding disorders. It's important to consult a healthcare provider before use, especially if taking other medications or having pre-existing health conditions.

Dosage

The typical minimum effective dose of maritime pine extract is around 50-100 mg per day, with an optimal dosage range of 100-200 mg per day. Doses above 200 mg per day are less commonly studied. There are no specific timing recommendations for administration. It is commonly available in capsule or tablet form. Bioavailability is generally good, but specific factors affecting absorption are not well-studied. No specific cofactors are required for its activity. Due to potential interactions with anticoagulants, it is crucial to adhere to recommended dosages and consult with a healthcare provider.

FAQs

Is Maritime Pine Extract effective for high cholesterol?

There is insufficient evidence to support its use for lowering LDL cholesterol levels. More research is needed to determine its efficacy for managing cholesterol.

How long does it take to see benefits from Maritime Pine Extract?

The onset of benefits can vary and is not well-documented. Some individuals may experience improvements within a few weeks, while others may require longer periods of consistent use.

Are there any interactions with medications?

Maritime pine extract may interact with anticoagulants, potentially increasing the risk of bleeding. Consult a healthcare provider before use, especially if taking blood-thinning medications.

Can Maritime Pine Extract help with skin health?

Some studies suggest potential benefits for skin health, such as improved elasticity and hydration, due to its antioxidant properties. However, more research is needed to confirm these effects.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/24346156/ – This study investigates the effect of pycnogenol on C-reactive protein (CRP) levels, a marker of inflammation. The results suggest that pycnogenol supplementation can significantly reduce CRP levels, indicating an anti-inflammatory effect. This finding supports the use of pycnogenol as a potential therapeutic agent for conditions involving inflammation.
https://journals.sagepub.com/doi/full/10.1177/1074248413511691 – This systematic review examines the effects of Pycnogenol on inflammatory biomarkers and nutritional status. The review highlights the potential anti-inflammatory properties of Pycnogenol and its role in modulating various inflammatory markers. The findings suggest that Pycnogenol could be a valuable supplement for managing inflammatory conditions.
https://pubmed.ncbi.nlm.nih.gov/29713620/ – This meta-analysis assesses the impact of Pycnogenol supplementation on blood pressure. The analysis, involving seven trials with 626 participants, did not find significant improvements in systolic blood pressure with Pycnogenol supplementation. This indicates that Pycnogenol may not be effective for lowering blood pressure.
https://journals.sagepub.com/doi/abs/10.1177/0003319719889428 – This study likely investigates the clinical applications and effects of Pycnogenol. The abstract suggests potential benefits in various health conditions, possibly related to its antioxidant and anti-inflammatory properties. Further details would be needed to fully understand the scope and findings of this research.
https://medlineplus.gov/druginfo/natural/1019.html – This resource from MedlinePlus provides general information about maritime pine extract (Pycnogenol). It covers uses, potential benefits, side effects, and precautions associated with its use. It serves as a reliable source for understanding the basic properties and safety considerations of Pycnogenol.