Maquibright Aristotelia Chilensis Berry Standardized Extract
Also known as: Aristotelia chilensis, Maqui, Maqui Berry
Overview
Maqui berry, scientifically known as *Aristotelia chilensis*, is a fruit native to southern Chile, celebrated for its high concentration of bioactive compounds, including anthocyanins, flavonoids, and other polyphenols. It is primarily utilized for its antioxidant and anti-inflammatory properties, with emerging research suggesting potential benefits in metabolic control, prevention of obesity, cancer, cognitive decline, and bone structure alterations. The berry is particularly rich in delphinidin 3-O-β-glucoside and contains monounsaturated and polyunsaturated fatty acids. While research is ongoing, current evidence is mainly derived from small-scale clinical trials and pre-clinical studies, indicating a need for more extensive, large-scale clinical trials to validate its effects comprehensively. Maqui berry is available in various forms, including standardized extracts, powders, and juices, making it a versatile addition to nutraceutical and functional food applications.
Benefits
Maqui berry extract has demonstrated significant benefits in alleviating dry eye symptoms. A pilot trial using MaquiBright™ standardized extract showed that a 60 mg/day dosage significantly increased tear fluid volume from 18.7±1.9 mm to 27.6±3.4 mm after 30 days, with sustained improvement at 60 days (P < 0.05). Both 30 mg and 60 mg dosages also led to significant decreases in the Dry Eye-related Quality of Life Score (DEQS), indicating improved quality of life. Additionally, pre-clinical and clinical studies suggest potential benefits in managing metabolic diseases due to its rich phytochemical composition, though more extensive clinical trials are needed. The high antioxidant and anti-inflammatory properties of maqui berries may contribute to these various health benefits, although further research is required to confirm these effects.
How it works
Maqui berries primarily exert their beneficial effects through their high antioxidant activity, which helps reduce oxidative stress. The polyphenols present in maqui berries also contribute to anti-inflammatory effects, potentially benefiting various health conditions. Specifically, in the context of dry eye, the antioxidant activity helps restore glandular activity in the lachrymal glands, improving tear fluid generation. Compounds like delphinidin 3-O-β-glucoside and other flavonoids interact with various molecular targets to exert these antioxidant and anti-inflammatory effects. Research is ongoing to enhance the systemic and luminal bioavailability of maqui berry polyphenols during their passage through the small intestine, optimizing their absorption and efficacy.
Side effects
Short-term studies have not reported significant adverse effects associated with maqui berry extract. A pilot trial assessing blood chemistry and rheology found no negative findings. However, comprehensive data on the long-term safety of maqui berry extract is currently limited. As such, caution is advised, particularly for pregnant or lactating women and children, as specific safety data for these populations is lacking. There are no known significant drug interactions reported in the available literature, nor are there any identified contraindications. Given the limited safety data, it is essential to monitor for any adverse reactions when starting maqui berry supplementation and to consult with a healthcare professional, especially for individuals with pre-existing health conditions or those taking medications.
Dosage
For alleviating dry eye symptoms, a dosage of 30 mg/day of MaquiBright™ standardized extract has shown effectiveness, but 60 mg/day appears to provide more significant and sustained benefits. The optimal dosage range, based on current studies, is between 30 mg to 60 mg per day. The maximum safe dose has not been definitively established in the current literature. In the pilot trial, daily supplementation was used. Efforts are ongoing to enhance the bioavailability of maqui berry polyphenols, which may influence future dosage recommendations. No specific cofactors have been identified as required for maqui berry supplementation. It is important to note that these recommendations are based on limited research, and individual responses may vary.
FAQs
Is maqui berry extract safe?
Short-term use appears safe based on limited studies, but long-term safety data is lacking. Monitor for any adverse reactions and consult with a healthcare professional.
When should I take maqui berry supplements?
Daily supplementation is recommended based on current studies, but specific timing considerations have not been established. Consistency is key.
What results can I expect from taking maqui berry?
You may experience improvement in dry eye symptoms and potential metabolic benefits due to its antioxidant and anti-inflammatory properties. Individual results may vary.
Are there any misconceptions about maqui berry?
There is limited evidence to support widespread health claims beyond antioxidant and anti-inflammatory effects. More research is needed to validate other potential benefits.
Can children or pregnant women take maqui berry?
No specific safety data is available for pregnant or lactating women, or children. Consult with a healthcare professional before use.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/25208615/ – This pilot trial investigated the effects of MaquiBright™ on dry eye symptoms in 13 healthy volunteers with moderately dry eyes. The study found that both 30 mg and 60 mg daily dosages significantly improved tear fluid volume and reduced dry eye symptoms over 60 days, suggesting a potential therapeutic benefit for individuals with dry eye.
- https://pubmed.ncbi.nlm.nih.gov/38540828/ – This review explores the nutritional characteristics and health benefits of Aristotelia chilensis (Maqui Berry). It highlights the high antioxidant activity and potential benefits for metabolic control, obesity, cancer, cognitive decline, and bone health, emphasizing the need for more large-scale clinical trials to validate these effects.
- https://repositorio.uchile.cl/bitstream/handle/2250/142064/Determination-of-polyphenolic-profile.pdf?sequence=1 – This study focuses on determining the polyphenolic profile of Maqui berries. It identifies key compounds contributing to the berry's antioxidant properties, providing a foundation for understanding its potential health benefits and applications in the food industry.
- https://www.researchgate.net/publication/378847237_A_Review_of_the_Functional_Characteristics_and_Applications_of_Aristotelia_chilensis_Maqui_Berry_in_the_Food_Industry – This review examines the functional characteristics and applications of Maqui Berry in the food industry. It discusses the berry's potential as a functional food ingredient due to its high antioxidant content and other beneficial compounds, highlighting its versatility in various food products.
- https://pubs.rsc.org/en/content/articlelanding/2024/fo/d3fo02524a/unauth – This review discusses the physiologic effects of Maqui Berry on metabolic homeostasis. It suggests potential benefits for managing metabolic diseases due to its phytochemical composition, while also noting that more robust clinical evidence is needed to confirm these effects.
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