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Manganese Lactate

Also known as: Manganese Lactate, Manganese

Overview

Manganese is an essential trace mineral vital for various physiological processes, including enzyme function, bone health, and metabolism. It is naturally found in foods such as nuts, whole grains, and leafy green vegetables. Manganese lactate is a specific form of manganese used in dietary supplements. While primarily used to address manganese deficiency, it is also being researched for potential benefits in conditions like osteoporosis and osteoarthritis, although current evidence is limited and requires further investigation. Manganese functions as a cofactor for numerous enzymes, including superoxide dismutase, which plays a crucial role in antioxidant defense. It is generally well-absorbed orally, but specific bioavailability data for manganese lactate is still emerging. Supplementation should be approached cautiously, adhering to recommended dosages to avoid potential adverse effects.

Benefits

Manganese lactate is primarily effective in treating manganese deficiency. Some studies suggest potential benefits in reducing the risk of metabolic syndrome, although the evidence is mixed. A systematic review indicates a possible non-linear relationship between manganese levels and metabolic syndrome risk. Adequate manganese intake is particularly important for infants and young children to support healthy growth and development. While manganese may support bone health and wound healing, the evidence for these benefits is not as strong. Clinical significance and effect sizes for most benefits are not yet well-quantified, and the time course of benefits remains to be fully established through further research.

How it works

Manganese functions primarily as a cofactor for various enzymes involved in bone formation, antioxidant defenses, and metabolic processes. It plays a crucial role in the activation of enzymes like superoxide dismutase (SOD), which protects cells from oxidative damage by neutralizing free radicals. Manganese interacts with several body systems, including the skeletal system, where it contributes to bone matrix formation, and the metabolic system, where it aids in glucose and lipid metabolism. Its absorption and bioavailability can be influenced by dietary factors, although specific data for manganese lactate are limited. The precise molecular targets and pathways are still under investigation, but its role as an enzyme activator is well-established.

Side effects

Manganese lactate is generally considered safe when taken orally at recommended doses. Common side effects are not typically reported at these levels. However, high doses of manganese can lead to neurological symptoms resembling Parkinson's disease, including tremors and muscle stiffness. It may also interfere with the absorption of quinolone and tetracycline antibiotics. High doses should be avoided, especially in individuals with liver disease or iron-deficiency anemia. Pregnant and breastfeeding women should adhere strictly to recommended dosages to avoid potential harm to the developing fetus or infant. Long-term use of high doses is not recommended due to the risk of neurotoxicity. The tolerable upper intake level (UL) for adults is 11 mg/day.

Dosage

The minimum effective dose of manganese lactate is not well-established. However, a daily intake of up to 11 mg is generally considered safe for adults, representing the tolerable upper intake level (UL). There are no specific timing recommendations for manganese lactate supplementation. While manganese lactate may offer better bioavailability compared to other forms, the evidence is limited. Absorption may be influenced by dietary factors, but specific data are lacking. It is crucial not to exceed the recommended upper limit of 11 mg/day to avoid potential adverse effects. Dosage recommendations may vary based on individual manganese status and specific health conditions.

FAQs

What is manganese lactate used for?

Manganese lactate is primarily used to treat manganese deficiency. It is also being researched for potential benefits in bone health and metabolic syndrome, though evidence is still emerging.

What are the potential side effects of manganese lactate?

When taken at recommended doses, manganese lactate is generally safe. High doses can lead to neurological symptoms similar to Parkinson's disease and may interfere with certain antibiotics.

What is the recommended dosage for manganese lactate?

The tolerable upper intake level (UL) for adults is 11 mg/day. It's important not to exceed this amount to avoid potential adverse effects. Consult a healthcare provider for personalized advice.

Can pregnant or breastfeeding women take manganese lactate?

Pregnant and breastfeeding women should not exceed the recommended daily allowance of manganese. Consult a healthcare provider before taking any manganese supplements during pregnancy or breastfeeding.

Does manganese lactate interact with any medications?

Manganese may interfere with the absorption of quinolone and tetracycline antibiotics. Consult with a healthcare provider or pharmacist to check for potential interactions with other medications.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10845892/ – This systematic review examines the role of manganese in metabolic syndrome. The findings suggest a mixed and potentially non-linear relationship between manganese levels and the risk of metabolic syndrome, highlighting the complexity of manganese's role in metabolic health.
https://www.webmd.com/vitamins/ai/ingredientmono-182/manganese – This WebMD article provides general information about manganese, including its uses, potential benefits, and side effects. It serves as a basic overview of manganese as a supplement and its role in the body.
https://pubmed.ncbi.nlm.nih.gov/35215474/ – This study investigates the association between dietary manganese intake and metabolic syndrome. The research contributes to the understanding of how manganese intake may influence the risk and development of metabolic syndrome.
https://lpi.oregonstate.edu/mic/minerals/manganese – The Oregon State University's Linus Pauling Institute provides a detailed overview of manganese, including its functions, dietary sources, and potential health benefits. It also covers deficiency symptoms and recommended intakes, offering a comprehensive resource for understanding manganese nutrition.
https://www.mdpi.com/2072-6643/14/4/825/review_report – This MDPI review report analyzes the current research on manganese and its impact on human health. It assesses the evidence for various health benefits and potential risks associated with manganese intake, providing a critical evaluation of the existing literature.