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Lycium Root Bark Extract

Also known as: Lycium Root Bark Extract, Goji Root Bark, Lycium barbarum root bark, Lycium chinense root bark, Lycii Radicis Cortex

Overview

Lycii Radicis Cortex is an herbal supplement derived from the root bark of *Lycium chinense* and, less commonly, *Lycium barbarum* (Goji berry). Native to Asia, these plants have been used in traditional medicine for their purported health benefits. The extract is characterized by its anti-inflammatory, antimicrobial, and antioxidant properties. While *Lycium barbarum* is well-known for its fruit, the root bark of *Lycium chinense* is specifically valued for its medicinal applications. Available primarily in capsule or powder form, Lycii Radicis Cortex is emerging as a potential therapeutic agent, though further research is needed to substantiate its effects. Current evidence is largely based on animal studies and small-scale human trials, indicating a need for more comprehensive systematic reviews and meta-analyses to fully understand its efficacy and safety.

Benefits

Lycii Radicis Cortex exhibits anti-inflammatory and antioxidant effects, potentially benefiting conditions like periodontitis and related bone loss, particularly with *Lycium chinense* root bark. Studies suggest that it may inhibit matrix metalloproteinase-8 and reduce the RANKL/OPG ratio, affecting bone resorption. While research on the root bark extract is limited, studies on *Lycium barbarum* fruit and polysaccharides indicate potential benefits for metabolic health and body weight management. However, these findings are primarily from animal studies or small-scale human trials, necessitating further research to confirm these benefits and determine their clinical significance. The evidence for benefits beyond anti-inflammatory and antioxidant effects is still emerging.

How it works

Lycii Radicis Cortex exerts its effects through multiple biological pathways. Primarily, it functions as an anti-inflammatory agent, reducing inflammation through various mechanisms. It also acts as an antioxidant, neutralizing free radicals and reducing oxidative stress. Specifically, it may inhibit matrix metalloproteinase-8 and modulate the RANKL/OPG ratio, influencing bone metabolism. These actions suggest interactions with the immune and skeletal systems. However, the precise mechanisms of absorption and bioavailability of the active compounds in root bark extracts are not yet fully understood.

Side effects

The overall safety profile of Lycii Radicis Cortex is considered generally safe, but comprehensive safety data are lacking. Common side effects are not well-documented, though potential gastrointestinal upset is possible. Rare side effects are currently unknown. Due to its antioxidant properties, there is a potential for interactions with blood thinners or diabetes medications. As a precaution, Lycii Radicis Cortex is contraindicated during pregnancy and breastfeeding due to the absence of sufficient safety data. Individuals with bleeding disorders or those taking anticoagulant medications should exercise caution. Further research is needed to fully characterize the side effect profile and potential drug interactions.

Dosage

Due to limited research, there is no established minimum effective dose, optimal dosage range, or maximum safe dose for Lycii Radicis Cortex. Recommendations for timing and administration are also not specified. It is typically available as capsules or powders. Absorption factors are not well-studied, and no required cofactors have been documented. Given the lack of comprehensive data, it is crucial to consult with a healthcare provider before using Lycii Radicis Cortex to determine appropriate dosage and ensure safety.

FAQs

Is Lycii Radicis Cortex safe to use?

It is generally considered safe, but comprehensive safety data are lacking. Consult a healthcare provider before use, especially if you have existing health conditions or are taking medications.

What are the expected benefits of taking Lycii Radicis Cortex?

Potential benefits include antioxidant and anti-inflammatory effects. Some studies suggest it may help with conditions like periodontitis, but more research is needed.

How should I take Lycii Radicis Cortex?

There are no specific timing recommendations. It is typically available in capsule or powder form. Consult a healthcare provider for personalized advice on dosage and administration.

Can Lycii Radicis Cortex interact with other medications?

Yes, due to its antioxidant properties, it may interact with blood thinners or diabetes medications. Consult your healthcare provider to discuss potential interactions.

Is Lycii Radicis Cortex the same as Goji berry fruit?

No, while both come from *Lycium* species, Lycii Radicis Cortex is derived from the root bark, while Goji berries are the fruit. They have different compositions and potential benefits.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC11590933/ – This study investigates the anti-inflammatory and antioxidant effects of Lycii Radicis Cortex (LRC) and its potential benefits for periodontitis and alveolar bone loss. The research indicates that LRC can inhibit matrix metalloproteinase-8 and reduce the RANKL/OPG ratio, which are key factors in bone resorption. However, the study lacks human trials and focuses specifically on *Lycium chinense*.
https://www.explorationpub.com/Journals/eff/Article/101070 – This study explores the potential health benefits of *Lycium barbarum*, commonly known as Goji berry. It suggests that the polysaccharides found in Goji berries may have positive effects on metabolic health and body weight management. However, it's important to note that this research focuses on the fruit rather than the root bark extract.
https://www.mdpi.com/2673-4168/5/2/35 – This review discusses the potential of *Lycium barbarum* as a functional food with various health benefits. It highlights the antioxidant and anti-inflammatory properties of Goji berries and their potential role in reducing cardiometabolic risk factors. The review emphasizes the need for further research to fully understand the mechanisms and clinical applications of *Lycium barbarum*.
https://jyoungpharm.org/8195/ – This article investigates the pharmacological properties and potential therapeutic applications of *Lycium barbarum*. It covers a range of benefits, including antioxidant, anti-inflammatory, and immunomodulatory effects. However, the focus is primarily on the fruit and its extracts, rather than the root bark.
https://www.drugs.com/npp/goji-berry.html – This resource provides general information about Goji berry (*Lycium barbarum*), including its uses, potential benefits, and safety considerations. It notes that Goji berries have been traditionally used for various health purposes, but clinical evidence is still limited. The information pertains to the fruit, not the root bark extract.