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Lcariin

Also known as: Epimedium flavonoid glycoside, Icariin glycoside, Icariin

Overview

Icariin is a flavonoid glycoside derived from the Epimedium genus, traditionally utilized in Chinese medicine for various therapeutic purposes. It is recognized for its anti-inflammatory and antioxidant properties, making it a candidate for addressing conditions like osteoarthritis and certain types of cancer. Icariin primarily works by modulating inflammatory pathways and exerting antioxidant effects. Although research on icariin is expanding, particularly through preclinical trials, robust clinical validation in humans is still required to substantiate its efficacy and safety.

Benefits

Icariin has demonstrated significant effects in reducing inflammatory cytokines; a meta-analysis reported a notable reduction in TNF-α levels (SMD=-6.326, 95%CI: -7.860, -4.791, p=0.000). The compound is also believed to enhance antioxidant capacities by modulating levels of superoxide dismutase (SOD) and inhibiting malondialdehyde (MDA) activity. Particularly, icariin shows promise for treating knee osteoarthritis, though further large-scale clinical trials are necessary to fully confirm these benefits and their clinical significance.

How it works

Icariin modulates inflammatory pathways by lowering levels of cytokines such as TNF-α and IL-1β. It interacts with body systems that regulate immune responses and oxidative stress, influencing various inflammatory mediators and antioxidant enzymes. However, detailed insights into its absorption and bioavailability in human subjects remain sparse.

Side effects

Icariin is generally regarded as safe based on preclinical studies, but comprehensive human data is lacking. Side effects remain poorly documented due to the limited number of studies in human populations. Potential, though speculative, drug interactions have not been established, and no specific contraindications have been determined. Precautions should be taken for pregnant or breastfeeding women due to insufficient safety data in these groups. Overall, documented side effects are minimal, but caution is warranted given the scarcity of conclusive human studies.

Dosage

The optimal dosage of icariin for humans has not been conclusively established, with preclinical studies suggesting a range of 3-300 mg/kg/day. Timing and form-specific recommendations are also unknown, and maximum safe doses for humans remain undetermined. As such, care should be exercised when considering the usage of icariin, and potential users should consult healthcare providers for personalized advice based on safety and efficacy.

FAQs

Is icariin safe for human use?

There is limited data on the safety of icariin in humans, so consult a healthcare provider before use.

What conditions might icariin help with?

Icariin shows potential for inflammatory conditions like osteoarthritis, but its efficacy in humans requires further study.

What are the expected results of icariin supplementation?

Potential anti-inflammatory and antioxidant effects are anticipated, though human evidence is needed for validation.

Can I take icariin if I am pregnant or breastfeeding?

Caution is advised during pregnancy and breastfeeding due to a lack of safety data.

How should I take icariin supplements?

Dosing guidelines are not well established; consult a healthcare provider for individualized advice.

Research Sources

  • https://d197for5662m48.cloudfront.net/documents/publicationstatus/145815/preprint_pdf/c6705927131cd1781b7440fb4aa02827.pdf – This systematic review and meta-analysis assessed the anti-inflammatory effects of icariin across various preclinical models, showing significant reductions in inflammatory markers such as TNF-α and IL-1β, confirming its potential as an anti-inflammatory agent.
  • https://pubmed.ncbi.nlm.nih.gov/30850271/ – This study outlines a systematic review protocol aimed at evaluating the safety and efficacy of icariin in treating knee osteoarthritis, potentially laying the groundwork for future clinical trials.
  • https://pubmed.ncbi.nlm.nih.gov/34918702/ – This meta-analysis highlighted the therapeutic efficacy of icariin concerning ovarian cancer cells, indicating potential applications in cancer treatment, though results remain preclinical.

Supplements Containing Lcariin

Horny Goat Weed by Doctor Recommended Supplements
68

Horny Goat Weed

Doctor Recommended Supplements

Score: 68/100
Boost For Her by NutriONN
63

Boost For Her

NutriONN

Score: 63/100
Men's X-Action Reloaded by Nature's Sunshine
78

Men's X-Action Reloaded

Nature's Sunshine

Score: 78/100