Lactocaseibacillus rhamnosus
Also known as: Lactocaseibacillus rhamnosus, Lactobacillus rhamnosus, Lactobacillus rhamnosus GG (LGG), Lacticaseibacillus rhamnosus GG
Overview
Lactocaseibacillus rhamnosus is a well-studied probiotic bacterium found in fermented foods and supplements, primarily recognized for its beneficial effects on gastrointestinal health. It is frequently used to support gut health, prevent antibiotic-associated diarrhea, and manage certain gastrointestinal conditions. Key characteristics include strain-specific benefits, a high survival rate through the digestive tract, and the ability to adhere to intestinal epithelial cells. Available in various forms such as capsules, tablets, and fermented foods, Lactocaseibacillus rhamnosus is supported by numerous systematic reviews and meta-analyses, providing a generally high level of evidence for its efficacy. Its ability to modulate gut microbiota, enhance barrier function, and influence immune response contributes to its therapeutic effects.
Benefits
Lactocaseibacillus rhamnosus has demonstrated effectiveness in preventing antibiotic-associated diarrhea in both children and adults, supported by high-quality evidence from systematic reviews and meta-analyses. Studies show it can reduce the incidence of diarrhea associated with antibiotic use. Additionally, it reduces the duration of diarrhea in acute gastroenteritis by approximately 0.85 days. Some evidence suggests potential benefits in infantile colic, although more research is needed to confirm these findings. The benefits are typically observed within a few days of supplementation, making it a valuable probiotic for managing gastrointestinal health.
How it works
Lactocaseibacillus rhamnosus exerts its beneficial effects through several mechanisms. It modulates the gut microbiota by increasing the population of beneficial bacteria and reducing harmful ones. It enhances the gut barrier function by promoting the production of mucin and tight junction proteins, which prevent the leakage of harmful substances into the bloodstream. Additionally, it influences the immune response by interacting with immune cells in the gut, potentially influencing cytokine production. Its ability to adhere to intestinal epithelial cells allows it to colonize the gut and exert its effects locally.
Side effects
Lactocaseibacillus rhamnosus is generally considered safe for most populations. Common side effects, occurring in more than 5% of users, include mild gastrointestinal symptoms such as bloating or gas. Uncommon side effects, affecting 1-5% of users, may include more severe gastrointestinal disturbances. Rarely, in less than 1% of cases, there is a potential for systemic infections in severely immunocompromised individuals. No significant drug interactions have been reported. However, it is generally not recommended for severely immunocompromised individuals. Caution is advised in critically ill patients or those with compromised immune systems to prevent potential adverse outcomes.
Dosage
The minimum effective dose of Lactocaseibacillus rhamnosus is typically ≥10^9 CFU per day, with optimal dosage ranges between 10^9 and 10^10 CFU per day. While the maximum safe dose is not well-defined, doses up to 10^10 CFU are commonly used without adverse effects. It is best taken with meals to enhance survival through the stomach. Available in capsules, tablets, and fermented foods, its survival through the gastrointestinal tract is high. No specific cofactors are required for its effectiveness. Always consult with a healthcare provider for personalized dosage recommendations.
FAQs
How should I store Lactocaseibacillus rhamnosus?
Store in a cool, dry place to maintain viability. Avoid exposure to high temperatures and humidity, which can reduce the effectiveness of the probiotic.
Is Lactocaseibacillus rhamnosus safe for everyone?
Generally safe, but caution is advised in immunocompromised individuals. Consult a healthcare provider before use if you have a compromised immune system.
When is the best time to take Lactocaseibacillus rhamnosus?
Can be taken at any time, but taking it with meals may enhance survival through the stomach and improve its effectiveness.
How long does it take to see results from taking Lactocaseibacillus rhamnosus?
Benefits are typically observed within a few days of supplementation, particularly for gastrointestinal issues like diarrhea.
Are all probiotics the same?
No, not all probiotics are created equal. Strain-specific benefits are important, and Lactocaseibacillus rhamnosus has specific benefits supported by research.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/26365389/ – This systematic review with meta-analysis, involving both adults and children, found that Lactocaseibacillus rhamnosus GG is effective in preventing antibiotic-associated diarrhea. While some studies had small sample sizes, the overall quality of evidence supports its use in preventing this condition.
- https://pubmed.ncbi.nlm.nih.gov/31025399/ – A systematic review with meta-analysis focused on children showed that Lactocaseibacillus rhamnosus reduces the duration of diarrhea in acute gastroenteritis by approximately 0.85 days. Despite high heterogeneity among the included studies, the evidence is considered of moderate to high quality, supporting its use in managing acute diarrhea in children.
- https://tp.amegroups.org/article/view/128126/html – This systematic review and meta-analysis explored the potential benefits of Lactocaseibacillus rhamnosus in infantile colic. The findings suggest some potential benefits, but the authors note that more research is needed to draw definitive conclusions due to the limited number of studies available.
- https://www.mdpi.com/2076-2607/11/11/2804 – This study investigates the impact of probiotics, including Lactocaseibacillus rhamnosus, on gut health and immune function. The research highlights the potential of these probiotics to modulate the gut microbiota and enhance immune responses, contributing to overall health and well-being.
- https://research.regionh.dk/en/publications/lacticaseibacillus-rhamnosus-gg-versus-placebo-for-eradication-of – This research compares the effectiveness of Lacticaseibacillus rhamnosus GG versus placebo for the eradication of specific infections. The study provides insights into the potential of this probiotic strain in managing and preventing certain types of infections, contributing to the understanding of its therapeutic applications.