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Lactobacillus Rhamnosus Lbv 96

Also known as: Lactobacillus rhamnosus LbV96, L. rhamnosus LbV96, Lactobacillus rhamnosus LbV96 (DSM 22560)

Overview

*Lactobacillus rhamnosus* is a species of lactic acid bacteria naturally found in fermented foods and the human gut. The LbV96 strain is a specific isolate used in probiotic formulations. It is primarily used to support gut health, immune function, and vaginal health. This strain is known for its ability to adhere to intestinal epithelial cells and produce antimicrobial substances. As a probiotic, it works by modulating the gut microbiota, enhancing immune function, and potentially influencing the vaginal microbiome through systemic effects. It is available in capsules, tablets, and fermented foods. Research on *L. rhamnosus* LbV96 is moderately mature, with systematic reviews and meta-analyses providing insights into its efficacy, particularly in improving vaginal health and supporting immune defense.

Benefits

*Lactobacillus rhamnosus* LbV96 has demonstrated benefits, particularly for women with vaginal dysbiosis. A meta-analysis showed that oral administration of *Lactobacillus* strains, including *L. rhamnosus* LbV96, significantly reduced the Nugent score, indicating improved vaginal health (SMD -0.561, CI -0.935 to -0.186, *P*=0.004). The odds ratio for improved Nugent scores was 3.936 (CI 1.702 to 9.100), indicating a significant effect of probiotics over placebo. It also supports immune defense and may help in preventing vaginal infections. Effects are generally observed within weeks of consistent use. While specific studies on *L. rhamnosus* LbV96 are limited, evidence supports its inclusion in broader probiotic blends for vaginal and gut health.

How it works

*Lactobacillus rhamnosus* LbV96 primarily works by modulating the gut microbiota and enhancing immune function. It interacts with the gastrointestinal and immune systems, with indirect effects on the vaginal microbiome. As a probiotic, it colonizes the gut and is not absorbed in the traditional sense. While specific molecular targets for *L. rhamnosus* LbV96 are not identified, probiotics generally interact with immune cells and epithelial barriers. The strain's ability to adhere to intestinal epithelial cells and produce antimicrobial substances contributes to its beneficial effects on gut and vaginal health.

Side effects

*Lactobacillus rhamnosus* LbV96 is generally considered safe for consumption. Common side effects include mild gastrointestinal symptoms such as bloating or gas. Serious adverse effects are rare but may include infections in immunocompromised individuals. No significant drug interactions have been reported. It is generally contraindicated in severely immunocompromised individuals. Caution is advised in pregnant or breastfeeding women due to limited data. Overall, it is well-tolerated, but individuals with specific health conditions should consult a healthcare provider before use.

Dosage

Optimal dosage ranges for *Lactobacillus rhamnosus* LbV96 are often included in blends with other *Lactobacillus* strains at doses ranging from 1 to 10 billion CFU per serving. There is no established maximum safe dose, but high doses are generally well-tolerated. It is best taken with food to enhance survival through the stomach. It is available in capsules, tablets, or as part of fermented foods. Survival through the stomach and small intestine is crucial for colonization. No specific cofactors are required.

FAQs

How should I store and handle *Lactobacillus rhamnosus* LbV96?

Ensure proper storage and handling to maintain viability. Follow the storage instructions on the product label, typically recommending refrigeration.

Is *Lactobacillus rhamnosus* LbV96 safe for everyone?

It is generally safe, but consult a healthcare provider if you are immunocompromised or have underlying health conditions.

When is the best time to take *Lactobacillus rhamnosus* LbV96?

It is best taken with meals to enhance survival through the stomach and promote colonization in the gut.

What results can I expect from taking *Lactobacillus rhamnosus* LbV96?

It may improve gut health and vaginal microbiota balance, supporting overall well-being and potentially preventing infections.

Is *Lactobacillus rhamnosus* LbV96 a cure for infections?

No, it is not a cure for all infections, but it may support prevention and overall health by balancing the gut and vaginal microbiota.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/31012733/ – This meta-analysis of four RCTs involving women with vaginal dysbiosis or bacterial vaginosis found that oral administration of *Lactobacillus* strains, including *L. rhamnosus* LbV96, significantly reduced the Nugent score, indicating improved vaginal health. The study highlights the potential of probiotics in managing vaginal health, though it notes the need for more long-term data and specific studies on individual strains.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9366906/ – This systematic review discusses the role of probiotics in maintaining vaginal microenvironment stability and immune defense. It emphasizes the potential of probiotics in supporting vaginal health by modulating the vaginal microbiota and enhancing immune responses. The review provides a broad overview of probiotic use in vaginal health, supporting the potential benefits of *L. rhamnosus* LbV96.
https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003050/htm – This meta-analysis focuses on the efficacy of probiotics in treating bacterial vaginosis. The findings suggest that probiotics can be an effective adjunctive treatment for bacterial vaginosis by restoring the balance of the vaginal microbiota. While not specific to *L. rhamnosus* LbV96, it supports the use of probiotics, including this strain, as part of a comprehensive treatment regimen.
https://www.ingentaconnect.com/content/wagac/bm/2019/00000010/00000005/art00001?crawler=true&mimetype=application%2Fpdf – This study investigates the effects of *Lactobacillus* strains on vaginal health. The research suggests that certain *Lactobacillus* strains can improve vaginal health by reducing the presence of harmful bacteria and promoting a healthy vaginal microbiome. The findings support the use of *L. rhamnosus* LbV96 as a probiotic for vaginal health.
https://www.spandidos-publications.com/10.3892/etm.2020.9090 – This study examines the impact of probiotics on vaginal health. The research indicates that probiotics can help maintain a balanced vaginal microbiome and reduce the risk of vaginal infections. The results suggest that *L. rhamnosus* LbV96 may be beneficial for promoting vaginal health.