Lactobacillus Plus Proprietary Blend
Also known as: Lactobacillus species, Lactobacillus probiotics, Lactobacillus Plus Proprietary Blend, Lactobacillus
Overview
Lactobacillus is a genus of Gram-positive, facultative anaerobic or microaerophilic bacteria found in various fermented foods like yogurt, kefir, sauerkraut, and kimchi. Known for their health-promoting properties, Lactobacillus strains are commonly included in probiotic supplements to support gut health, immune function, and metabolic health. These probiotics are recognized for their ability to withstand the harsh conditions of the gastrointestinal tract and establish beneficial presence in the gut microbiota. Extensive research, including numerous randomized controlled trials (RCTs) and meta-analyses, underlines the significant health benefits associated with Lactobacillus supplementation, showcasing its role in digestive health and cholesterol management among other effects.
Benefits
Lactobacillus probiotics provide several evidence-based health benefits, particularly in gastrointestinal health. They have been shown to significantly reduce the risk of antibiotic-associated diarrhea (AAD), with a pooled relative risk of 0.58 found in a meta-analysis of 63 RCTs involving 11,811 participants. Additionally, Lactobacillus supplementation has been associated with significant reductions in LDL cholesterol by approximately 5.27 mg/dL and total cholesterol by about 4.84 mg/dL in overweight or obese individuals. Immune system support has also been indicated, although evidence is less consistent in this area. The benefits of Lactobacillus have been demonstrated across diverse populations, particularly those experiencing gastrointestinal disorders or metabolic challenges.
How it works
Lactobacillus probiotics primarily exert their effects by modulating the gut microbiota, enhancing the intestinal barrier function, and influencing immune responses. They promote a healthy balance of gut bacteria and act on biological pathways associated with gut and immune health. These interactions occur through specific targeting of pattern recognition receptors and modulation of cytokine signaling pathways, ultimately contributing to improved gastrointestinal and overall systemic health.
Side effects
Lactobacillus supplementation is generally considered safe for most individuals. Common side effects, occurring in more than 5% of users, may include mild gastrointestinal symptoms such as bloating, gas, and altered bowel habits. Uncommon side effects, affecting 1-5% of users, could involve the risk of infections in those who are immunocompromised. Serious adverse effects are extremely rare (<1%). There are typically no reported significant drug interactions, but caution is advised in immunocompromised individuals, and pregnant women or those with severe underlying health conditions should also consult a healthcare provider before starting supplementation. Care must be taken to store probiotics correctly to maintain their viability.
Dosage
The recommended minimum effective dose for Lactobacillus is typically at least 1 × 10^9 CFU (colony-forming units) per day, while an optimal dosage range for specific health benefits is around 1 × 10^10 CFU daily. There are no established upper safety limits, with high doses generally well tolerated. It is advised to take Lactobacillus with food, enhancing its survival through the stomach. Available forms include capsules, powders, and tablets, which should be chosen based on individual preference and absorption factors, with no specific cofactors required for effectiveness.
FAQs
How should Lactobacillus supplements be stored?
Store Lactobacillus probiotics in a cool, dry place, and keep them refrigerated if recommended to maintain viability.
Is Lactobacillus safe for everyone?
Lactobacillus is generally safe but consult a healthcare provider if you are immunocompromised or have severe health conditions.
When is the best time to take Lactobacillus?
For optimal survival through the digestive tract, take Lactobacillus supplements with food.
How long before I see benefits from Lactobacillus supplementation?
Benefits from Lactobacillus may be observed within a few weeks to months of consistent supplementation.
Are all probiotics the same?
No, different probiotic strains have varying effects; it's crucial to choose specific strains based on desired benefits.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35820261/ – This systematic review and meta-analysis involving 598 participants from nine RCTs found that Lactobacillus supplementation significantly reduced LDL and total cholesterol levels, indicating metabolic benefits in overweight or obese adults.
- https://jamanetwork.com/journals/jama/fullarticle/1151505 – A comprehensive meta-analysis of 63 RCTs with 11,811 participants showed that Lactobacillus probiotics significantly reduced the risk of antibiotic-associated diarrhea, bolstering gastrointestinal health.
- https://bmjopen.bmj.com/content/11/8/e043054 – This study examined various RCTs demonstrating beneficial effects of Lactobacillus on immune function, though the effects varied among different populations and specific strains.
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