Lactobacillus plantarum PBS067
Also known as: Lactiplantibacillus plantarum PBS067, L. plantarum PBS067, Lactobacillus plantarum strain PBS067, Lactobacillus plantarum PBS067
Overview
Lactiplantibacillus plantarum PBS067 is a probiotic bacterial strain belonging to the Lactobacillaceae family. It is commonly found in fermented foods and the human gastrointestinal tract. This specific strain is investigated for its potential health benefits, particularly in improving vaginal health, modulating immune responses, and aiding metabolic health. L. plantarum PBS067 exhibits antimicrobial activity against pathogens, immunomodulatory effects, and the ability to enhance mucosal barrier function. It is used in probiotic supplements aimed at restoring or maintaining a healthy microbiota balance and reducing inflammation. Emerging research, including randomized controlled trials and meta-analyses, supports its use, particularly for vaginal health in post-menopausal women and for broader metabolic and immune benefits in healthy adults. The strain is considered safe and well-tolerated, making it a promising candidate for probiotic applications.
Benefits
L. plantarum PBS067 has demonstrated several potential health benefits. A randomized controlled trial showed that it significantly improves vaginal health in post-menopausal women, with a 50% improvement in Vaginal Health Index (VHI) scores and a reduction in vaginal pH and pro-inflammatory cytokines. Meta-analyses suggest that L. plantarum supplementation can lead to modest but consistent reductions in body weight and BMI in healthy adults, along with improvements in abdominal fat and inflammatory markers. Furthermore, L. plantarum has been shown to modulate the immune system by increasing anti-inflammatory cytokine IL-10 and decreasing pro-inflammatory cytokines. These benefits are particularly relevant for post-menopausal women seeking to improve vaginal health and for healthy adults aiming to manage weight and enhance immune function. While the evidence for vaginal health is strong, more strain-specific research is needed to confirm the metabolic and immune benefits of PBS067.
How it works
L. plantarum PBS067 exerts its probiotic effects through several mechanisms. Primarily, it modulates the mucosal microbiota by increasing the population of beneficial lactobacilli and inhibiting the growth of pathogens. This helps to restore a balanced microbial environment. Additionally, it reduces local inflammation by downregulating pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α, while enhancing the production of anti-inflammatory cytokines like IL-10. By acting on the mucosal immune system, gastrointestinal tract, and vaginal microbiota, L. plantarum PBS067 helps to restore homeostasis and reduce inflammation. Its molecular targets include cytokine signaling pathways and microbial pathogen inhibition through competitive exclusion and antimicrobial production.
Side effects
L. plantarum strains, including PBS067, are generally recognized as safe (GRAS) with no serious adverse events reported in clinical trials. The most commonly reported side effects associated with probiotic use, though not specifically documented for PBS067, are mild gastrointestinal symptoms such as bloating and gas. These symptoms are typically transient and resolve on their own. No uncommon or rare side effects have been reported in high-quality RCTs. There are no known significant drug interactions associated with L. plantarum PBS067. However, individuals who are immunocompromised should consult with their healthcare provider before using probiotic supplements. Caution is advised in severely immunocompromised patients. Overall, L. plantarum PBS067 appears to have a favorable safety profile based on available evidence.
Dosage
The minimum effective dose of L. plantarum PBS067, based on a vaginal health RCT, is 3 billion CFU daily for 28 days, though this was in combination with other probiotics. Optimal dosage ranges typically fall between 1 and 10 billion CFU daily for probiotic strains; however, the exact optimal dose for PBS067 alone requires further study. There is no established upper limit for safe dosage, but doses up to 10 billion CFU daily are generally well-tolerated. Daily administration is recommended, and the duration of supplementation varies depending on the indication. Oral capsules or vaginal suppositories can be used depending on the target site. Survival through gastric acid and bile is important for efficacy, and formulations may include protective coatings. No specific cofactors are required for its activity.
FAQs
Is L. plantarum PBS067 safe for long-term use?
Current evidence suggests that L. plantarum PBS067 is safe for short to medium-term use. Long-term data is limited, but no significant safety concerns have emerged from available studies.
Can PBS067 be used alone or only in combination?
Clinical evidence for PBS067 is primarily based on its use in combination with other probiotics. Further research is needed to determine the isolated effects of PBS067.
How quickly can benefits be expected from PBS067?
Improvements in vaginal health have been observed within 4 weeks of supplementation. Metabolic and immune effects may take longer to manifest.
Does L. plantarum PBS067 require refrigeration?
Whether refrigeration is required depends on the specific formulation of the probiotic product. Many probiotic products benefit from refrigeration to maintain viability.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/39062848/ – This meta-analysis of 9 RCTs found that L. plantarum supplementation reduced body weight, BMI, abdominal fat, and inflammatory markers compared to placebo in healthy adults. The effect was enhanced when multiple strains were used. The study highlights the potential of L. plantarum in managing metabolic health, but acknowledges the need for more robust trials to confirm these findings.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10857347/ – This randomized controlled trial involving post-menopausal women showed that L. plantarum PBS067, in combination with other probiotics, significantly improved vaginal health index scores, reduced vaginal pH, and decreased pro-inflammatory cytokines after 28 days. The study suggests that this probiotic combination can effectively improve vaginal health in post-menopausal women. However, the combined probiotic intervention limits the ability to draw PBS067-specific conclusions.
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.643420/full – This meta-analysis of RCTs demonstrated that L. plantarum increased the anti-inflammatory cytokine IL-10 and decreased pro-inflammatory cytokines IL-4, IFN-γ, and TNF-α, suggesting immunoregulatory effects. The study indicates that L. plantarum can modulate the immune system, potentially benefiting individuals with inflammatory conditions. However, the authors note heterogeneity and small sample sizes in some studies as limitations.
- https://www.sciopen.com/article/10.26599/AGR.2024.9340028 – This study investigates the effects of probiotics, including L. plantarum, on muscle function in older adults. While the study suggests potential benefits, strain-specific data for PBS067 is lacking. Further research is needed to confirm these findings and determine the specific effects of PBS067 on muscle function in older adults.
- https://www.mdpi.com/2076-2607/12/3/441 – This review explores the potential benefits of probiotics, including L. plantarum, on oral and systemic well-being. While the review suggests potential benefits, strain-specific data for PBS067 is lacking. Further research is needed to confirm these findings and determine the specific effects of PBS067 on oral and systemic health.
Recommended Articles
Top Ingredients for Optimal Gut Health
Fiber, probiotics, prebiotics, hydration, and fermented foods are crucial for maintaining healthy digestion and gut function.
Best Probiotic Strains & CFU for Health
Certain probiotic strains like Lactobacillus and Bifidobacterium, with CFU counts ranging from 1 billion for general wellness to 100 billion for conditions like IBS, are most beneficial.
Best Probiotic Strains for Your Health Goals
Certain probiotic strains offer targeted benefits for digestive health, immune support, weight management, and mental health.
Top Digestive Health Ingredients
Dietary fiber, probiotics, and natural ingredients like ginger and peppermint oil are essential for improving digestive health.