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Lactobacillus Paracasei Mak92l81p

Also known as: Lactobacillus paracasei, Lacticaseibacillus paracasei Mak92l81p, Lacticaseibacillus paracasei CNCM I-1518, Lacticaseibacillus paracasei TISTR 2593, Lacticaseibacillus paracasei K56, Lacticaseibacillus paracasei LP-33, Lacticaseibacillus paracasei F19, Lacticaseibacillus paracasei BRAP01, Lacticaseibacillus paracasei HB89, Lacticaseibacillus paracasei

Overview

Lacticaseibacillus paracasei, formerly known as Lactobacillus paracasei, is a gram-positive, facultative anaerobic bacterium commonly found in fermented dairy products and the human gut. It is widely recognized as a probiotic supplement aimed at improving gastrointestinal health, modulating immune responses, and potentially alleviating allergic and metabolic conditions. While the specific strain Mak92l81p lacks extensive direct documentation, the broader species and its closely related strains (e.g., CNCM I-1518, TISTR 2593, K56) have been the subject of numerous studies, including systematic reviews and randomized controlled trials. Research generally supports its probiotic effects, particularly in immune modulation and gastrointestinal benefits, with emerging evidence for its role in metabolic regulation and stress reduction. It is typically consumed in fermented foods, capsules, or powders.

Benefits

Lacticaseibacillus paracasei offers several evidence-based benefits. A systematic review and meta-analysis of fermented dairy drinks containing *L. paracasei* subsp. *paracasei* CNCM I-1518 indicated a reduction in the incidence, duration, and severity of common infectious diseases, including respiratory and gastrointestinal infections, though data heterogeneity was noted. For allergic rhinitis, systematic reviews suggest that strains like LP-33 can improve symptoms and quality of life, reducing nasal itching and pro-inflammatory cytokines such as IL-5, particularly with doses of at least 10^10 CFU/day over 8 weeks. In terms of metabolic health, strain TISTR 2593 has shown anti-adipogenic effects in vitro, significantly downregulating adipogenic markers (PPAR-γ, C/EBP-α) and reducing lipid accumulation by approximately 50%, suggesting potential benefits in obesity-related metabolic regulation. Furthermore, supplementation with strain K56 has been associated with reduced perceived stress, anxiety, and insomnia, alongside an increase in *L. paracasei* abundance in the gut microbiota, as observed in a controlled trial. These benefits are supported by moderate to high-quality evidence, with effect sizes varying by strain and condition.

How it works

Lacticaseibacillus paracasei exerts its effects through multiple mechanisms. It modulates the immune system by enhancing the production of anti-inflammatory cytokines, such as IL-10, and reducing pro-inflammatory mediators like IL-5. The bacterium can inhibit the adhesion and growth of pathogens through the production of antimicrobial substances and competitive exclusion. Specific strains, such as TISTR 2593, influence adipocyte differentiation by downregulating key transcription factors like PPAR-γ and C/EBP-α, thereby reducing lipid storage. *L. paracasei* is known for its ability to survive the harsh conditions of the gastrointestinal tract, including gastric acidity and bile salts, and can adhere to intestinal epithelial cells. This adherence and survival allow it to modulate the gut microbiota composition, promoting a healthier balance of beneficial bacterial populations. Its molecular targets include various immune signaling pathways and genes involved in adipogenesis.

Side effects

Lacticaseibacillus paracasei is generally recognized as safe (GRAS) for consumption, with no reported virulence factors or antimicrobial resistance genes in well-studied strains. Adverse effects are rare and typically mild, primarily involving transient gastrointestinal symptoms such as bloating, gas, or mild abdominal discomfort. These symptoms usually subside with continued use as the body adjusts. There are no significant drug interactions or contraindications reported in high-quality clinical studies. However, individuals with compromised immune systems, those with severe underlying medical conditions, or those undergoing immunosuppressive therapy should exercise caution and consult a healthcare provider before initiating supplementation, as data for these specific populations are limited. Pregnant and breastfeeding women should also seek medical advice. Overall, the safety profile is favorable for the general healthy population when consumed within recommended dosages.

Dosage

Effective dosages of Lacticaseibacillus paracasei in clinical studies typically range from 10^9 to 10^11 Colony Forming Units (CFU) per day. The duration of supplementation varies depending on the desired outcome; for instance, stress reduction effects have been observed within 2 weeks, while improvements in allergic rhinitis symptoms may require 6-8 weeks of consistent use. *L. paracasei* is available in various formulations, including fermented dairy products, capsules, and powders. While the bacterium is known for its survival through gastric acid and bile, co-administration with food may further enhance its viability and absorption. There are no specific cofactors required for its efficacy, but a healthy gut environment generally supports probiotic benefits. It is important to adhere to the dosage recommendations provided by the product manufacturer or a healthcare professional, and to be aware that higher doses do not necessarily equate to greater benefits and may increase the likelihood of mild gastrointestinal discomfort.

FAQs

Is L. paracasei Mak92l81p specifically studied?

Direct high-quality studies on the Mak92l81p strain are currently limited. Evidence regarding its benefits is primarily extrapolated from research on other closely related and well-studied Lacticaseibacillus paracasei strains.

Is L. paracasei safe for daily use?

Yes, Lacticaseibacillus paracasei is generally considered safe for daily use in healthy individuals. Clinical trials have reported minimal and usually mild side effects, such as temporary bloating or gas.

How soon can I expect to see benefits from L. paracasei?

The onset of benefits varies. Some effects, like stress reduction, may be observed within 2 weeks, while others, such as improvements in allergy symptoms, typically require 6-8 weeks of consistent supplementation.

Does L. paracasei require refrigeration?

The need for refrigeration depends on the specific product formulation. Many probiotic supplements benefit from refrigeration to maintain bacterial viability, but some are shelf-stable due to advanced manufacturing techniques. Always check the product label for storage instructions.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC7698120/ – This systematic review and meta-analysis evaluated the effects of fermented dairy drinks containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 on common infectious diseases. It found significant reductions in the incidence and duration of infections, particularly respiratory and gastrointestinal, though heterogeneity in outcomes limited some pooled analyses. The study highlights the immune-modulating potential of this specific strain.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1501395/full – This in vitro and genomic study investigated Lacticaseibacillus paracasei TISTR 2593, demonstrating its strong anti-adipogenic effects by downregulating key markers of fat cell differentiation. The research also confirmed its safety profile, finding no virulence factors or antimicrobial resistance genes. This suggests potential metabolic benefits, though in vivo validation is needed.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1544713/full – This randomized controlled trial examined the effects of Lacticaseibacillus paracasei strain K56 supplementation on gut microbiota and psychological stress. It reported significant modulation of gut microbiota composition and reductions in perceived stress, anxiety, and insomnia after two weeks. The study provides evidence for the gut-brain axis modulation by this specific probiotic strain.