Lactobacillus gasseri LBA N157
Also known as: Lactobacillus gasseri, L. gasseri, Lactobacillus gasseri LBA N157
Overview
Lactobacillus gasseri LBA N157 is a specific strain of lactic acid bacteria, a type of probiotic commonly found in the human gastrointestinal and vaginal microbiota. As a probiotic supplement, its primary aim is to enhance gut health, modulate immune responses, and potentially support metabolic and cognitive functions. Key characteristics of L. gasseri include its ability to survive the harsh conditions of the gastrointestinal tract, adhere to mucosal surfaces, and interact with the host's immune system. While research on the broader L. gasseri species is moderately mature with multiple randomized controlled trials and mechanistic studies, specific public literature on the LBA N157 strain is limited. The overall evidence quality for L. gasseri varies depending on the specific strain and the health indication being studied.
Benefits
Some strains of *Lactobacillus gasseri* have demonstrated benefits in various areas. For gut health and inflammation, strains like ATCC33323 have shown efficacy in reducing intestinal inflammation in animal models of colitis by increasing *Lactobacillus* levels and modulating mucosal immune responses, with significant gene copy number increases (p<0.001). In terms of cognitive function, oral administration of *L. gasseri* MG4247 improved synaptic plasticity markers and acetylcholine metabolism in an amyloid beta-induced cognitive impairment mouse model, suggesting potential neuroprotective effects. Intestinal isolates of *L. gasseri* exhibit higher survival rates in simulated intestinal juice compared to vaginal isolates, indicating strain-specific adaptation crucial for oral probiotic efficacy. *Lactobacillus* species, including *L. gasseri*, can activate pattern recognition receptors in the gut mucosa, leading to systemic immune effects such as anti-inflammatory Treg cell migration to the lungs and downregulation of inflammatory cytokines. While not specific to LBA N157, meta-analyses on *Lactobacillus* probiotics suggest potential for modest reductions in body weight and fat mass in overweight individuals, though strain-specific effects are noted.
How it works
*Lactobacillus gasseri* exerts its effects primarily through interactions with intestinal epithelial cells and immune cells. It engages with pattern recognition receptors, such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs), thereby modulating both innate and adaptive immune responses. This interaction can enhance the integrity of the mucosal barrier and lead to the production of beneficial metabolites that inhibit pathogenic bacteria. In neurological contexts, *L. gasseri* has been observed to influence neurotransmitter metabolism, specifically acetylcholine, and the expression of synaptic proteins, likely through pathways involving the gut-brain axis. The specific genetic adaptations of individual *L. gasseri* strains play a crucial role in their survival within the gastrointestinal tract and their overall probiotic functionality.
Side effects
*Lactobacillus gasseri* is generally recognized as safe (GRAS) and has a long history of use in fermented foods and dietary supplements. Adverse effects are rare, but some individuals may experience mild gastrointestinal symptoms such as bloating or gas, particularly when first initiating supplementation. There are no significant drug interactions or contraindications that have been consistently reported in high-quality clinical studies. However, as with all probiotics, caution is advised for immunocompromised individuals, and its use in such populations should be considered on a case-by-case basis under medical supervision. Overall, the safety profile of *L. gasseri* is favorable for healthy adults.
Dosage
Specific dosing guidelines for *Lactobacillus gasseri* LBA N157 are not well-established in the current scientific literature. However, clinical studies involving other *L. gasseri* strains have typically utilized daily doses ranging from 10^7 to 10^11 Colony Forming Units (CFU). Oral administration is the standard route, and formulations are often designed to enhance the survival of the bacteria as they pass through the acidic environment of the stomach. For optimal efficacy and colonization, co-administration with prebiotics (non-digestible food ingredients that promote the growth of beneficial microorganisms) may be beneficial. Users should follow product-specific instructions or consult a healthcare professional for personalized dosage recommendations, especially given the lack of specific LBA N157 data.
FAQs
Is LBA N157 effective for weight loss?
While the *Lactobacillus gasseri* species has shown potential benefits for weight management in some studies, specific high-quality evidence for the LBA N157 strain's efficacy in weight loss is currently lacking.
Is it safe for long-term use?
Yes, *Lactobacillus gasseri* strains, including LBA N157, are generally considered safe for long-term consumption in healthy adults, with a low incidence of side effects.
How quickly do benefits appear?
Effects on gut microbiota and inflammation may be observed within a few weeks of consistent use. More complex benefits, such as those related to cognitive function or metabolic health, may require longer-term supplementation to become apparent.
Research Sources
- https://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1012541 – This animal study investigated the effects of *Lactobacillus gasseri* ATCC33323 in a mouse model of colitis. It found that the probiotic significantly increased *Lactobacillus* gene copies in the gut and reduced markers of inflammation (p<0.001), supporting its anti-inflammatory potential. The study highlights the strain-specific effects of probiotics in modulating gut health.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11851505/ – This preclinical study used a mouse model of amyloid beta-induced cognitive impairment to evaluate *Lactobacillus gasseri* MG4247. The results showed that treatment with this strain improved acetylcholine levels and synaptic protein expression compared to controls, suggesting potential neuroprotective effects and a role in cognitive function. The findings point towards gut-brain axis modulation.
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.03146/full – This comparative phenotypic assay demonstrated that *Lactobacillus gasseri* strains isolated from the intestine exhibited significantly better survival rates in simulated gastrointestinal conditions than those isolated from the vagina. This research underscores the importance of the origin and adaptation of probiotic strains for their efficacy when administered orally, impacting their ability to reach and colonize the gut.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1042189/full – This review discusses how *Lactobacillus* species, including *L. gasseri*, interact with the host immune system. It highlights their ability to activate pattern recognition receptors in the gut mucosa, leading to systemic immune effects such as the migration of anti-inflammatory Treg cells to the lungs and the downregulation of inflammatory cytokines. This mechanism contributes to their immunomodulatory properties.
- https://www.ffhdj.com/index.php/FunctionalFoodScience/article/view/1115/4402 – This meta-analysis on *Lactobacillus* probiotics indicates potential for modest reductions in body weight and fat mass in overweight human subjects. It emphasizes that the effects are strain-specific and highlights the variability in clinical endpoints. The study suggests a role for *Lactobacillus* in metabolic health, mediated by gut microbiota interactions.
Supplements Containing Lactobacillus gasseri LBA N157
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