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Lactobacillus Casei R0215nd

Also known as: Lactobacillus casei R0215, Lactobacillus casei Shirota, L. casei, Lactobacillus casei var. rhamnosus, Lactobacillus casei

Overview

*Lactobacillus casei* is a lactic acid bacterium prevalent in various fermented foods such as yogurt, cheese, and pickled vegetables, and is also available as a dietary supplement. This strain is noted for its beneficial effects on gastrointestinal health and immune function, thanks to its ability to survive the challenging conditions of the gastrointestinal tract and adhere to intestinal cells. The body of research on *L. casei* is substantial, including numerous randomized controlled trials (RCTs) and systematic reviews that validate its health advantages, particularly in the prevention of antibiotic-associated diarrhea (AAD) and management of inflammation in osteoarthritis. Recognized for its potential therapeutic properties, *L. casei* is a popular supplement choice amongst those seeking probiotic support.

Benefits

*Lactobacillus casei* has multiple evidence-supported benefits, notably reducing the risk of AAD with a relative risk (RR) of 0.32, indicating a significant 68% reduction in risk, as backed by systematic reviews encompassing several RCTs. Additionally, this strain has been found to assist in reducing pain and inflammation related to osteoarthritis, enhancing patients' quality of life significantly, as evidenced by studies with large participant groups. Furthermore, there is some support for its role in boosting the immune system and potentially aiding in common infectious diseases, although evidence remains less convincing for pediatric populations compared to adults. Overall, the most substantial evidence endorses *L. casei* for AAD prevention and osteoarthritis symptoms management.

How it works

*Lactobacillus casei* operates predominantly by colonizing the gastrointestinal tract, thereby reinforcing gut barrier integrity and modulating immune responses. By fostering a balanced gut microbiome, it effectively reduces inflammation and optimizes digestive health. While specific molecular interactions with intestinal epithelial cells and immune cells are still being researched, the strain's ability to survive acidic stomach conditions and thrive in the intestines maximizes its beneficial probiotic effects.

Side effects

*Lactobacillus casei* is generally considered safe for most individuals, with mild gastrointestinal side effects being the most frequently reported, occurring in over 5% of users, such as bloating, gas, and abdominal discomfort. Allergic reactions are rare, affecting fewer than 5% of users, and severe adverse reactions are uncommon, primarily presenting risks for immunocompromised individuals. While no significant drug interactions have been identified, it is advisable for those with serious immune deficiencies to avoid probiotic usage. Pregnant and breastfeeding women should also exercise caution, despite the strain typically being regarded as safe. The long-term safety profile of *L. casei* has not been thoroughly investigated, warranting a consultation with healthcare providers for individuals with underlying health concerns prior to initiating supplementation.

Dosage

The recommended daily dosage of *Lactobacillus casei* generally falls between 10^8 and 10^{10} Colony-Forming Units (CFU). For preventing AAD specifically, a daily intake of 2 × 10^9 CFU has shown effectiveness in clinical contexts. While no upper safe limit has been firmly established, higher doses tend to offer no additional benefits and are usually not advocated. For optimal effects, it is suggested to take the supplement with meals to enhance its survival through the gastrointestinal tract. Various delivery forms, including capsules, powders, and fermented dairy products, exist, and absorption may be enhanced with enteric coatings or natural food sources.

FAQs

Is *Lactobacillus casei* safe to consume?

Yes, *Lactobacillus casei* is generally accepted as safe, though care is advised for immunocompromised individuals.

When is the best time to take *Lactobacillus casei*?

It is best taken with meals to optimize its survival and efficacy.

How long before I can see benefits?

Benefits for AAD prevention can occur within days, while osteoarthritis management might take several weeks.

Are all *Lactobacillus casei* strains effective?

No, effectiveness can vary by strain; some strains, such as *L. casei* R0215, have well-documented benefits.

Research Sources

https://www.ncbi.nlm.nih.gov/pubmed/29392871 – A systematic review of randomized trials supporting the efficacy of *Lactobacillus casei* in reducing antibiotic-associated diarrhea shows a significant risk reduction, underscoring its value in probiotic therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071527/ – Research highlighting the anti-inflammatory effects of *Lactobacillus casei* in osteoarthritis identified improvements in pain management and quality of life for patients after consistent probiotic use.