Lactobacillus Casei Extract
Also known as: L. casei, Lactobacillus casei Shirota (LcS), Lactobacillus casei
Overview
*Lactobacillus casei* is a species of lactic acid bacteria predominantly found in fermented foods such as yogurt and cheese. As a probiotic supplement, it is renowned for its role in promoting gastrointestinal health, supporting immune function, and potentially alleviating allergic responses. This probiotic is characterized by its resilience to harsh stomach conditions, allowing it to successfully colonize the intestines. The body of research surrounding *L. casei* is moderately mature, with numerous studies providing robust evidence of its efficacy, particularly in gastrointestinal health and immune modulation. With various forms available—from capsules and tablets to dairy products—*L. casei* serves as a versatile option for individuals seeking to enhance gut microbiota and overall health.
Benefits
*Lactobacillus casei* has several evidence-backed benefits that include immune system modulation, where it influences B cells and cytokines. Studies indicate that it significantly reduces inflammation markers such as CRP and IL-6, especially in surgical patients. It is also associated with improvements in gastrointestinal health, reducing the risk of infections post-surgery. Some evidence supports its role in managing allergic rhinitis, although findings are mixed. The effects are most beneficial for individuals with compromised gut health and those recovering from surgical procedures. Meta-analyses have validated these outcomes, highlighting the probiotic's clinical significance in enhancing immune function and gut flora balance.
How it works
*Lactobacillus casei* operates primarily through its interactions within the gastrointestinal tract, where it modulates gut microbiota composition and enhances immune responses. It promotes the production and regulation of critical cytokines such as TNF-α and IL-10, which are pivotal in immune system function. Furthermore, by surviving the passage through the stomach, it effectively colonizes intestinal regions, supporting overall gut health and providing a barrier against pathogens.
Side effects
*Lactobacillus casei* is generally recognized as safe, with mild side effects like bloating or gas being the most common reports. Uncommon but more serious side effects may include gastrointestinal disturbances, particularly in sensitive individuals. Rare cases of infection have been noted in immunocompromised populations, underscoring the importance of assessing individual risks before supplementation. Interaction with medications, notably immunosuppressants, calls for caution. Pregnant or breastfeeding individuals should seek medical guidance due to limited clinical data on safety in these populations.
Dosage
For *Lactobacillus casei*, the recommended daily dosage typically ranges from 1 to 20 billion CFU (Colony Forming Units), depending on the intended health benefit. Generally, 1-10 billion CFU is considered the minimum effective dose. For optimal effects, especially in enhancing gut health and immune function, higher doses may be advisable. It's recommended to consume this probiotic with food to improve its survival and absorption through the digestive tract, and while generally safe, doses beyond 20 billion CFU should be approached with caution.
FAQs
How should I store *Lactobacillus casei* supplements?
Store in a cool, dry place to preserve viability; refrigeration is often recommended.
Is *Lactobacillus casei* safe for everyone?
Generally safe, but individuals with immunocompromised conditions should consult healthcare providers.
When is the best time to take *Lactobacillus casei*?
It is best taken with meals to enhance absorption.
How long does it take to see benefits from *Lactobacillus casei*?
Improvements in gut health or immune function are typically observed within a few weeks.
Can *Lactobacillus casei* cure allergies?
It may help manage symptoms of allergic rhinitis, but it is not a definitive cure.
Research Sources
- https://all-imm.com/index.php/aei/article/download/507/824/6107 – This meta-analysis involving 2708 patients reported significant improvements in quality of life metrics for those with allergic rhinitis, showcasing *L. casei*'s potential in allergy management despite some heterogeneity among studies.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11572271/ – This review investigated immune modulation and conclusively identified *L. casei*'s role in affecting immune cells and cytokine production, thereby presenting moderate to high-quality evidence of its efficacy.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6307089/ – The systematic review included 3028 patients and emphasized *L. casei*'s effectiveness in reducing surgical infections and inflammation markers, supporting its clinical benefits in surgical contexts with notable findings of high quality.
Supplements Containing Lactobacillus Casei Extract
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