Lactobacillus Acidophilus Rosell 418
Also known as: Lactobacillus acidophilus Rosell 418, Lactobacillus acidophilus, Probiotic strain of Lactobacillus acidophilus, *Lactobacillus acidophilus* Rosell-52
Overview
*Lactobacillus acidophilus* Rosell-52 is a specific strain of Gram-positive, homofermentative probiotic bacteria commonly found in fermented foods like yogurt and the human gut microbiome. It is primarily used as a dietary supplement to enhance gut health, prevent antibiotic-associated diarrhea (AAD), and alleviate symptoms of irritable bowel syndrome (IBS). As a probiotic, Rosell-52 works by modulating gut microbiota, improving intestinal barrier function, and supporting immune responses. Current research indicates varying levels of evidence regarding its efficacy, with most studies focusing on its general benefits as a strain of *Lactobacillus acidophilus* rather than exclusively on Rosell-52. The available clinical trials suggest promise, though systematic reviews remain limited.
Benefits
Studies indicate that *Lactobacillus acidophilus* Rosell-52 may significantly reduce the incidence and duration of antibiotic-associated diarrhea, particularly when used in combination with other probiotics such as *Lactobacillus rhamnosus* Rosell-11. It has also shown potential in improving stool consistency and alleviating symptoms related to acute diarrhea. The strain is particularly beneficial for children and adults undergoing antibiotic treatments. Despite variations in effect sizes across different studies, its clinical significance is notable, with improvements generally observed within days to weeks of use. Some evidence suggests it may also reduce levels of *Clostridium difficile* and improve IBS symptoms.
How it works
The action of *Lactobacillus acidophilus* Rosell-52 involves modulation of the gut microbiota, enhancing the intestinal barrier, and supporting immune system homeostasis. It interacts with gastrointestinal and immune systems by increasing the expression of tight junction proteins such as occludin, claudin-1, and ZO-1, which are critical for maintaining intestinal integrity. This strain primarily colonizes the gut rather than being absorbed into the bloodstream, demonstrating a localized beneficial effect.
Side effects
Overall, *Lactobacillus acidophilus* Rosell-52 is deemed safe for most populations. Common side effects may include mild gastrointestinal symptoms such as bloating and gas, though severe adverse events are rare. Immunocompromised individuals face a theoretical risk of infection due to probiotic administration, prompting a recommendation for consultation with healthcare providers before use. There are no significant drug interactions reported, but care is advised for those with severe immunodeficiency. Generally, it has a favorable safety profile with no known severe side effects.
Dosage
While a specific minimum effective dose for Rosell-52 has not been established, typical effective dosages for probiotics range between 1 to 10 billion CFU per day. The optimal dosage for *Lactobacillus acidophilus* Rosell-52 is generally suggested within this range. Although no maximum safe dose is well-defined, high dosages are usually tolerated without issues. To enhance probiotic efficacy, it's recommended to take the supplements with food, as this aids survival through the stomach's acidic environment. Common forms include capsules or powders that provide easier absorption.
FAQs
How should *Lactobacillus acidophilus* Rosell-52 be stored?
It should be stored in a cool, dry place to maintain its viability.
Is it safe for everyone to take?
Generally safe, but immunocompromised individuals should consult a healthcare provider before use.
When is the best time to take it?
Probiotics are best taken with meals to enhance survival through the digestive tract.
What can I expect from taking this probiotic?
You may experience improved gut health and reduced diarrhea symptoms with supplementation.
Is it a remedy for all digestive problems?
No, it's not a cure-all; benefits can vary based on individual health circumstances.
Research Sources
- https://www.optibacprobiotics.com/professionals/probiotics-database/lactobacillus/lactobacillus-acidophilus/lactobacillus-acidophilus-rosell-52 – This source provides a comprehensive overview of Lactobacillus acidophilus Rosell-52, detailing its health benefits, mechanisms of action, and safety profile, supporting its use in probiotic applications.
- https://pubmed.ncbi.nlm.nih.gov/35138584/ – A randomized controlled trial indicated that, in combination with Lactobacillus rhamnosus Rosell-11, Rosell-52 significantly reduced the incidence and duration of antibiotic-associated diarrhea in children, showcasing its effectiveness as a probiotic.
- https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2022.983075/full – This systematic review assessed the effectiveness of Lactobacillus acidophilus and found limited clinical benefits for diarrhea treatment, highlighting the necessity for more strain-specific studies.
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