Lactobacillus Acidophilus Nas
Also known as: L. acidophilus, Acidophilus, Lactobacillus acidophilus
Overview
*Lactobacillus acidophilus* is a probiotic bacterium commonly found in the human digestive tract, mouth, and vagina, as well as in fermented foods such as yogurt and kefir. It is known for its beneficial effects on gastrointestinal health and immune support, while also potentially playing a role in cholesterol management. This organism produces lactic acid, which aids in maintaining an optimal gut environment. Research on *L. acidophilus* shows variable quality, with a mix of robust and inconsistent findings across various health claims. Practices vary in its use among populations, often within probiotic supplements aimed at enhancing gut flora, especially for those dealing with digestive irregularities and other health concerns.
Benefits
Evidence-based benefits of *Lactobacillus acidophilus* include: 1. **Cholesterol Reduction:** Demonstrated a decrease in total cholesterol and LDL cholesterol levels, with a meta-analysis showing a mean difference of -0.17 mmol/L for total cholesterol and -0.22 mmol/L for LDL-C. 2. **Gastrointestinal Health:** Provides mixed results in treating diarrhea, particularly in children, but has shown potential to shorten the duration of diarrhea episodes. 3. **Glycemic Control:** Supplementation may effectively lower fasting plasma glucose levels in overweight and obese adults. These benefits highlight *L. acidophilus*’s significance, particularly for children with acute gastroenteritis and individuals seeking to improve cholesterol profiles.
How it works
*Lactobacillus acidophilus* functions primarily by modulating gut microbiota, enhancing immune responses, and possibly regulating lipid metabolism. By producing lactic acid, it promotes an environment that inhibits pathogenic bacteria while supporting the growth of beneficial organisms. This interaction primarily affects the gastrointestinal system and immune health, although the specific molecular targets remain largely undefined.
Side effects
Typically, *Lactobacillus acidophilus* is well tolerated among healthy individuals, with common side effects including mild gastrointestinal discomfort, such as bloating or gas occurring in over 5% of users. More severe side effects are rare; however, individuals who are severely immunocompromised may face risks of systemic infections. No major drug interactions have been identified, but it is advisable for immunocompromised patients to avoid probiotics. Special caution should be exercised in these populations, given the potential for adverse effects.
Dosage
The effective dosing of *Lactobacillus acidophilus* varies, with guidelines suggesting a minimum dose of approximately 10 billion colony-forming units (CFU) for gastrointestinal support. The optimal daily intake typically ranges between 1 to 10 billion CFU. Timing is essential; to enhance efficacy, it is recommended to administer the probiotic with food. Forms such as capsules, powders, and fermented foods are commonly used, and while there isn't a defined upper limit, higher doses are usually well tolerated. Enhancing survival in the gastrointestinal tract may involve co-administration with antacids.
FAQs
Is *Lactobacillus acidophilus* safe?
Yes, it is generally safe for most individuals, but caution is advised for those with compromised immune systems.
When is the best time to take it?
It is best taken with meals to improve its survival through stomach acidity.
What benefits can I expect?
Benefits can vary by individual, but typically include gastrointestinal health, cholesterol reduction, and potential glycemic control.
Are there any misconceptions?
Many overestimate its effectiveness for all gastrointestinal issues; it is not a one-size-fits-all solution.
Research Sources
- https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2022.983075/full – This article discusses the important roles of probiotics, including *L. acidophilus*, in modifying lipid profiles, showing significant reductions in cholesterol levels.
- https://pubmed.ncbi.nlm.nih.gov/26473340/ – A systematic review indicated that while *L. acidophilus* may reduce the duration of diarrhea in children, evidence quality varies, affecting efficacy perception.
- https://www.semanticscholar.org/paper/A-Systematic-Review-and-Meta-Analysis:-acidophilus-Cheng-Ma/2d73fe56771e3971012bb7a9f4ff22b12169130c – A comprehensive meta-analysis highlighted benefits of *Lactobacillus* supplementation in reducing both LDL and total cholesterol, along with improvements in fasting glucose levels in specific populations.
- https://pubmed.ncbi.nlm.nih.gov/35820261/ – This study examines the effects of various probiotics, finding that *L. acidophilus* can play a key role in improving metabolic health outcomes among overweight users.
- https://pubmed.ncbi.nlm.nih.gov/35277042/ – Research suggests that *L. acidophilus* supplementation can significantly improve gastrointestinal health, although results can vary depending on dosage and duration.
Supplements Containing Lactobacillus Acidophilus Nas
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