Alanylglutamine
Also known as: L-Alanyl-L-Glutamine, Alanyl-Glutamine, Sustamine (brand name)
Overview
L-Alanyl-L-Glutamine (alanylglutamine) is a dipeptide molecule, consisting of L-glutamine and L-alanine, two amino acids. Alanylglutamine is sometimes supplemented before prolonged physical exercise to enhance electrolyte absorption and improve endurance. Preliminary rodent evidence suggests alanylglutamine is more effective at increasing muscular glutamine content after supplementation than glutamine itself. This is because glutamine is absorbed by the liver and intestines after supplementation. Since alanylglutamine is a dipeptide molecule, it contains more than one amino acid for the intestines to absorb, allowing glutamine to reach the muscles. Though alanylglutamine supplementation results in greater glutamine muscular content, this has not been shown to provide a performance enhancing effect. Current evidence suggests alanylglutamine may be a more effective supplement than glutamine because of its increased stability and water solubility, but more research is needed to determine if it actually has an effect on performance.
Benefits
Alanylglutamine is a dipeptide that combines glutamine and alanine, which enhances its stability and solubility compared to glutamine alone. This structure allows for better absorption in the intestines, leading to increased availability of glutamine to the muscles. The mechanism involves the dipeptide being absorbed more efficiently, which may result in higher muscular glutamine levels.
How it works
Alanylglutamine supplementation is associated with several potential benefits, including improved hydration and electrolyte absorption during prolonged physical activity, enhanced endurance, and increased muscular glutamine content. However, while it may increase glutamine levels in muscles, current evidence does not support a significant performance-enhancing effect.
Side effects
Current studies on L-alanyl-L-glutamine use a dose of 1-3g a day. More research is needed to determine the optimal dose. L-Alanyl-L-Glutamine supplementation may be similar to glutamine supplementation, in terms of dose, timing, and purpose.
Dosage
There are no significant side effects reported for alanylglutamine when taken at recommended dosages. However, as with any supplement, individuals should consult with a healthcare provider before starting supplementation, especially if they have underlying health conditions or are taking other medications.
FAQs
What is Alanylglutamine?
Alanylglutamine is a dipeptide molecule consisting of L-glutamine and L-alanine, used to enhance electrolyte absorption and improve endurance.
How does Alanylglutamine work?
Alanylglutamine works by providing a more stable and soluble form of glutamine that is absorbed more efficiently in the intestines, allowing for greater availability to muscles.
What are the benefits of Alanylglutamine?
The benefits of alanylglutamine include improved hydration, enhanced endurance, and increased muscular glutamine content, although it does not significantly enhance performance.
What is the recommended dosage for Alanylglutamine?
The recommended dosage for alanylglutamine is 1-3g a day, but more research is needed to determine the optimal dose.
Are there any side effects of Alanylglutamine?
There are no significant side effects reported for alanylglutamine when taken at recommended dosages, but consulting a healthcare provider is advised.