Irvingia Gabonensis Extract
Also known as: Irvingia gabonensis, African mango, Wild mango, Bush mango
Overview
Irvingia gabonensis extract, derived from the seeds of the Irvingia gabonensis tree native to West Africa, is a botanical dietary supplement primarily used for weight management and metabolic health. It is rich in fiber, polyphenols, and other bioactive compounds believed to influence lipid and carbohydrate metabolism. The supplement is marketed for obesity management and improving cardiovascular risk factors. Research includes randomized controlled trials (RCTs) and systematic reviews/meta-analyses, but the overall evidence quality is mixed due to methodological limitations in many studies. It is traditionally used for its purported benefits in weight management and metabolic health. The extract is available in various forms, including capsules and powders, and is often included in weight loss supplement formulations. While promising, further high-quality research is needed to fully establish its efficacy and long-term safety.
Benefits
Irvingia gabonensis extract has demonstrated potential benefits in weight management and metabolic health, primarily in overweight or obese adults. Meta-analyses of RCTs indicate significant reductions in body weight, body fat, and waist circumference with supplementation. One meta-analysis reported statistically significant decreases in body weight and waist circumference with doses ranging from 200 to 3150 mg/day over 4 to 10 weeks. Some studies suggest improvements in lipid profiles and cardiovascular biomarkers, as well as enhanced fat oxidation rates. However, the evidence is not consistently strong across all studies, and more research is needed to confirm these secondary effects and to determine the long-term benefits and optimal usage guidelines.
How it works
Irvingia gabonensis extract appears to modulate carbohydrate and lipid metabolism, potentially normalizing saccharide and lipid metabolism pathways. It may increase fat oxidation rates, contributing to reductions in adiposity. Bioactive compounds such as soluble fiber and polyphenols may influence satiety, lipid absorption, and antioxidant status. Molecular targets are not fully elucidated but likely involve metabolic enzymes and pathways related to energy homeostasis. The exact mechanisms and bioavailability specifics require further investigation to fully understand how Irvingia gabonensis exerts its effects.
Side effects
Irvingia gabonensis extract is generally considered safe, with no significant adverse effects reported in clinical trials. Common side effects are not well-documented, suggesting low incidence or mild tolerability issues. No significant drug interactions or contraindications have been identified in the reviewed literature. However, limited data exist for special populations such as pregnant women and children, so caution is advised. As with any supplement, individuals should monitor for any adverse reactions and discontinue use if they occur. Further research is needed to fully characterize the long-term safety profile and potential risks in specific populations.
Dosage
Effective doses of Irvingia gabonensis extract in clinical studies range from 200 mg to 3150 mg per day, with supplementation durations typically lasting 4 to 10 weeks. There is no established maximum safe dose beyond the studied ranges, and longer-term safety data are limited. Timing and form-specific recommendations are not standardized, although most studies use seed extract capsules. Absorption factors and required cofactors have not been clearly defined. It is advisable to start with a lower dose and gradually increase as tolerated, while monitoring for any adverse effects. Consultation with a healthcare professional is recommended before starting supplementation.
FAQs
Is Irvingia gabonensis extract effective for weight loss?
Yes, evidence from meta-analyses of RCTs supports modest but significant weight loss and waist circumference reduction over short-term use.
Is it safe to use?
Current data indicate a favorable safety profile with no major adverse effects reported in clinical trials.
How long does it take to see results?
Benefits generally appear within 4 to 10 weeks of daily supplementation, according to clinical studies.
Are there any known drug interactions?
None have been reported in clinical trials, but it's always best to consult with a healthcare provider.
Can it be used long-term?
Long-term safety and efficacy data are lacking, so caution is advised. Short-term use appears to be safe.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31855111/ – This systematic review and meta-analysis included 5 RCTs assessing Irvingia gabonensis seed extract effects on anthropometric and cardiovascular outcomes. The meta-analysis showed significant reductions in body weight, body fat, and waist circumference (p < 0.05). However, the study notes limitations including the small number of high-quality trials and short duration.
- https://www.ncbi.nlm.nih.gov/books/nbk132337/ – This resource provides general information about dietary supplements. While it doesn't specifically focus on Irvingia gabonensis, it offers a broader context for understanding the regulation and evaluation of dietary supplements, which is helpful in interpreting research on this extract.
- https://www.jscimedcentral.com/jounal-article-info/Annals-of-Public-Health-and-Research/Positive-Effect-of-Irvingia-Gabonensis-on-Health-and-Weight-Loss-11774 – This review of clinical and animal studies confirms Irvingia gabonensis seed extract's ability to normalize carbohydrate and lipid metabolism and facilitate weight loss with doses of 200-3150 mg/day over 4-10 weeks. The review also notes that no significant adverse effects were reported in the included studies, supporting its safety profile.
- https://www.mdpi.com/2072-6643/14/21/4646 – This study investigated Irvingia gabonensis kernel extract's effect on fat oxidation rates, showing increased fat oxidation in overweight/obese subjects. The study's adequate sample size and control details support the conclusion that Irvingia gabonensis has metabolic benefits beyond just weight loss.
- https://magistralbr.caldic.com/storage/product-files/69448140.pdf – This document provides product information on Irvingia gabonensis extract. While not a primary research source, it offers insights into the typical dosages and formulations used in commercially available supplements, which can be helpful for understanding practical applications.
