Hydrolyzed Collagen Type Ii
Also known as: Collagen Peptides, Hydrolyzed Collagen, Hydrolyzed Collagen Type II
Overview
Hydrolyzed Collagen Type II is a protein supplement derived from cartilage, typically sourced from chicken or other animals. It undergoes hydrolysis to break it down into smaller peptides, enhancing its bioavailability. Primarily used to improve skin health, including hydration and elasticity, and joint health, it is rich in amino acids like glycine and proline, essential for collagen synthesis. Research on Hydrolyzed Collagen Type II is moderately mature, with several clinical trials supporting its benefits, particularly for short-term skin improvements. However, more research is needed to fully understand its long-term effects and efficacy across diverse populations. It is available in powder and capsule forms, making it a versatile addition to daily health routines.
Benefits
Hydrolyzed Collagen Type II is primarily known for its benefits to skin health. Studies show significant improvements in skin hydration and elasticity, often within 8-12 weeks. Some research also indicates a reduction in wrinkles. While less researched than its skin benefits, it may also support joint health. These benefits have been mainly studied in women aged 30-60 years. Improvements in skin hydration and elasticity are often statistically significant. Benefits are typically observed within 2-3 months of consistent supplementation. Overall, the evidence is generally positive for short-term skin benefits, although the quality and outcomes of studies can vary.
How it works
Hydrolyzed collagen peptides are absorbed into the bloodstream and stimulate the body's natural collagen synthesis processes. These peptides interact with fibroblasts, the cells responsible for producing collagen, thereby promoting increased collagen production in the skin and potentially in joints. This stimulation helps improve skin hydration, elasticity, and overall skin health. The absorption of these peptides is relatively rapid, with peak serum levels typically reached within 1-2 hours after ingestion. By providing the building blocks needed for collagen production, hydrolyzed collagen supports the structural integrity of skin and connective tissues.
Side effects
Hydrolyzed Collagen Type II is generally considered safe for most individuals, with minimal reported side effects. The most common adverse effect, though rare, is mild gastrointestinal discomfort. There are no significant drug interactions reported with hydrolyzed collagen supplementation. However, individuals with known allergies to collagen or its sources should avoid its use. Pregnant or breastfeeding women should consult with their healthcare providers before starting supplementation. While generally safe, it's important to be aware of potential allergic reactions and to monitor for any adverse effects, especially when starting a new supplement regimen.
Dosage
The typical recommended dosage of Hydrolyzed Collagen Type II ranges from 2.5 to 10 grams per day. For skin benefits, a dosage of 5-10 grams per day is often recommended. While a maximum safe dose is not definitively established, dosages up to 10 grams per day are generally considered safe. There is no specific timing recommended for taking hydrolyzed collagen; it is often taken once daily. It is available in both powder and capsule forms, offering flexibility in administration. Absorption is generally good, but it may vary depending on the specific hydrolysis process used in its production. No specific cofactors are required for its absorption or effectiveness.
FAQs
Is Hydrolyzed Collagen Type II safe?
It is generally safe, but consult a healthcare provider if you have allergies to collagen sources or are pregnant/breastfeeding.
When should I take Hydrolyzed Collagen Type II?
It can be taken at any time of day, as there are no specific timing recommendations. Consistency is key for seeing results.
How long before I see results?
Improvements in skin hydration and elasticity are typically observed within 2-3 months of consistent supplementation.
Can Hydrolyzed Collagen Type II cure skin or joint issues?
It is not a cure but can support skin and joint health. Results may vary, and it may not work for everyone.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/ – This systematic review and meta-analysis, encompassing 1721 patients across 26 RCTs, primarily focused on the effects of hydrolyzed collagen on skin hydration and elasticity. The study found significant improvements in these parameters with collagen supplementation over a duration of 2-12 weeks. However, the authors noted variability in study quality and collagen sources as limitations.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10773595/ – This systematic review and meta-analysis, which included 967 patients across 14 RCTs, evaluated the impact of hydrolyzed collagen on skin hydration and elasticity. The study concluded that hydrolyzed collagen supplementation improves both skin hydration and elasticity. The authors noted that there was limited data available regarding the long-term effects of collagen supplementation.
- https://pubmed.ncbi.nlm.nih.gov/33742704/ – This systematic review and meta-analysis, involving 1125 participants across 19 studies, focused on the effects of collagen supplementation on skin aging. The study found that collagen supplementation reduces wrinkles and improves skin elasticity and hydration over a period of up to 90 days. The authors noted that most participants were female and that there was limited long-term data available.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10102402/ – This research article discusses the absorption and bioavailability of collagen peptides. It highlights that collagen peptides are rapidly absorbed, with peak serum levels reached within 1-2 hours after ingestion. This rapid absorption contributes to the effectiveness of hydrolyzed collagen in stimulating collagen synthesis and supporting skin health.
- https://onlinelibrary.wiley.com/doi/10.1111/ijd.15518 – This study provides evidence supporting the use of collagen supplements for improving skin health. It highlights the potential of collagen to reduce wrinkles and enhance skin elasticity. The findings contribute to the growing body of evidence supporting the benefits of hydrolyzed collagen for skin aging and overall skin quality.
Supplements Containing Hydrolyzed Collagen Type Ii

Collagen Enhance 1000 mg
ResVitale

Collagen HydraPlump With Ceramides
ResVitale

Collagen Enhance Burgundy Berry
ResVitale

BioCell Collagen II With Hyaluronic Acid 1000 mg
The Vitamin Shoppe

Dr. Hotze's Hair Skin and Nails Formula
Physician's Preference

BioCell Collagen II With Hyaluronic Acid 1000 mg
The Vitamin Shoppe
Ultra Collagen Enhance
ResVitale

Collagen Enhance
ResVitale

Extra Strength Glucosamine Hyaluronic Acid Chondroitin MSM Shellfish-Free
Solgar
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