Hops Strobile Extract
Also known as: Hops, Hop strobile, *Humulus lupulus* L.
Overview
Hops are the flowering cones of the *Humulus lupulus* plant, traditionally used in beer production and known for their diverse medicinal properties. The plant's extracts are rich in bioactive compounds such as alpha acids, beta acids, and xanthohumol, which are linked to its biological activity. Hops are valued in herbal medicine for their antimicrobial, anxiolytic, and potential neuroprotective effects, though research is ongoing to fully elucidate these properties. Current evidence includes randomized controlled trials and in vitro studies, establishing hops extracts as a significant herbal component in dietary supplements aimed at addressing anxiety and promoting general wellness. Despite promising findings, further investigation is needed to confirm and expand upon these effects, particularly regarding their neuroprotective capabilities.
Benefits
Hops extracts exhibit several evidence-based benefits, including: 1. **Antimicrobial Activity**: Strong antibacterial effects against Methicillin-resistant *Staphylococcus aureus* (MRSA) have been documented, with minimum bactericidal concentrations varying significantly based on extraction method, especially effective with 95% ethanol. 2. **Anxiolytic and Mood-Improving Effects**: A randomized, placebo-controlled trial found that a daily intake of hops extract led to significant reductions in anxiety, depression, and stress ratings among young adults, suggesting its efficacy in managing mood disorders. 3. **Neuroprotective Properties**: Although less studied in humans, components like xanthohumol show potential as antioxidants with protective effects in neural contexts. These benefits are particularly relevant for young adults exhibiting anxiety or mood disorders, evidenced by substantial clinical improvements over a treatment period of several weeks.
How it works
Hops' antimicrobial activity is primarily due to its alpha and beta acids, which disrupt bacterial cell membranes, leading to cell death. The anxiolytic effects are associated with modulation of the GABAergic system alongside other neurotransmitter pathways, although these mechanisms are not yet fully understood. Xanthohumol, a key component, contributes antioxidant properties and potential neuroprotective effects by interacting with various cellular processes. The bioavailability of these extracts can be enhanced by extraction methods like supercritical carbon dioxide and ethanol extraction.
Side effects
Hops extracts are generally deemed safe for most individuals when used as directed, with no significant common side effects reported in studies. While uncommon and rare side effects are not well-documented, there have been no severe adverse reactions identified. Caution is advised when using hops extracts concurrently with sedatives or central nervous system depressants due to potential additive depressive effects. There are no specific contraindications, but those with allergies to hops should avoid their use. Pregnant or breastfeeding individuals are advised to seek medical consultation before consumption, given the limited safety data in these populations.
Dosage
For therapeutic benefits, a minimum effective dose of 0.2 grams per day has been suggested for anxiolytic effects, commonly administered in two 0.1-gram capsules. While the optimal dose for antimicrobial outcomes remains less defined, continuing research points to this dosage as safe without observable adverse effects. Timing considerations have not been specifically outlined, although co-administration with meals may enhance absorption. Recommended preparations include ethanol extracts with minimal 70% concentration for optimal extraction of active ingredients. Factors like extraction method critically influence the bioavailability of the active compounds.
FAQs
Are hops extracts safe to use?
Yes, hops extracts are generally safe; however, individuals with allergies to hops or using sedatives should exercise caution.
How should I take hops supplements?
There are no strict timing recommendations, but it's often advisable to take hops extracts with meals for better absorption.
What benefits can I expect from hops extract?
Hops extracts may significantly improve anxiety, depression, and stress scores, particularly observed over a treatment period of 4 weeks.
Can I find medicinal properties in hops apart from beer production?
Yes, hops have significant medicinal properties, including antimicrobial and anxiolytic effects, beyond their use in beer.
Research Sources
- https://openpublishing.library.umass.edu/jmap/article/1780/galley/1738/download/ – This study highlights the strong bactericidal activity of hops extracts against MRSA, especially effective when extracted with 95% ethanol. The findings underline the potential of hops as a natural antimicrobial agent.
- https://pubmed.ncbi.nlm.nih.gov/28742505/ – In a randomized controlled trial, this research demonstrated that hops extracts could significantly reduce anxiety, depression, and stress in young adults, suggesting its therapeutic potential in mood disorders.
- https://cjas.agriculturejournals.cz/artkey/cjs-201707-0003_effect-of-dietary-supplement-of-herbal-extract-from-hop-humulus-lupulus-on-pig-performance-and-meat-quality.php – This animal study explored the effects of hops extract on pig performance, showing it beneficial for oxidative stability, yet revealed some drawbacks at higher dosages, illustrating the need for careful dosage considerations.
- https://www.mdpi.com/2076-3921/12/9/1722 – This paper reviewed the antioxidant properties of xanthohumol, elucidating its potential neuroprotective effects, which could have implications for human health and necessitates further research.
- https://www.cir-safety.org/sites/default/files/humulus%20lupulus%20(hops).pdf – This comprehensive review discusses the safety profile of hops, confirming no significant adverse effects but advising caution for specific populations such as pregnant women and those with allergic sensitivities.
Supplements Containing Hops Strobile Extract

Alteril All Natural Sleep Aid with L-Tryptophan
Global Product Management

David Winston's Old World Bitters
Herbalist & Alchemist

David Winston's Phytocalm
Herbalist & Alchemist

Passiflora Combination
Genestra Brands

Phytocillin
Herbs Etc.

Phytocillin
Herbs Etc.

Phytocillin
Herbs Etc.

Phytocillin
Herbs Etc.

Phytocillin
Herbs Etc.

Sleep Aide
Vital Nutrients

David Winston's Old World Bitters
Herbalist & Alchemist

SleepBlend
Vitanica