Hop Flower Extract
Also known as: Hops, Hop Flower, Humulus lupulus
Overview
Hop flower extract is derived from the flowers of the *Humulus lupulus* plant, primarily recognized for its role in beer brewing. This extract is rich in bioactive compounds, such as terpenes and flavonoids, especially 8-prenylnaringenin (8-PN), which is known for mimicking estrogen behavior in the body. Commonly utilized for its phytoestrogenic effects, hop extract is frequently employed to support bone health and alleviate menopausal symptoms. The evidence from clinical trials and systematic reviews indicates moderate research maturity, with findings suggesting positive effects on bone mineral density in postmenopausal women amidst others. While there is promising data, further research is necessary to deeply understand the full extent of its health benefits across diverse populations.
Benefits
The primary benefits of hop flower extract include its support for bone health and reduction of menopausal symptoms, especially in postmenopausal women. A significant randomized controlled trial evidenced that the extract could lead to at least a 1% increase in total body bone mineral density (BMD) in 61% of participants. Additionally, a systematic review found evidence supporting the reduction of hot flashes in menopausal women through the use of this extract. The positive influence on gut microbiota was also noted, suggesting holistic benefits. Overall, the benefits observed are strengthened by high-quality evidence and are particularly relevant for postmenopausal women facing related health challenges.
How it works
Humulus lupulus works primarily through the action of 8-PN, a phytoestrogen that binds to estrogen receptors (ERα and ERβ), mimicking natural estrogen effects. This interaction positively influences bone metabolism, helping to enhance bone density in postmenopausal women and reduce vasomotor symptoms associated with menopause. The extract’s interaction with the endocrine system presents a mechanism for alleviating menopausal discomfort and supporting overall bone health.
Side effects
Overall, hop flower extract is considered safe when taken as directed, although comprehensive long-term safety data is still lacking. Clinical studies did not document significant adverse effects at standard doses. However, potential interactions exist with estrogen-sensitive medications due to its phytoestrogenic properties, caution is advised for women with estrogen-sensitive cancers. Pregnant or breastfeeding individuals should consult healthcare professionals prior to use. No common (>5%) or uncommon (1-5%) side effects were reported, and rare (<1%) side effects have not been highlighted in peer-reviewed studies. Despite the favorable safety profile, it’s prudent for users to approach this supplement carefully, particularly those who are taking relevant medications.
Dosage
The recommended effective dose of hop flower extract for enhancing bone health was established at 1 capsule per day, standardized for 8-PN, during a clinical trial; the exact dosage of 8-PN per capsule remains unspecified. While no upper safety limits are established, it is noted that the doses in trials have not produced adverse effects. There are no specific timing considerations; therefore, consistency in daily intake is likely beneficial. The capsule form appears effective, and while specific absorption factors aren't cited, the evidence from studies suggests sufficient bioavailability of the active components. Additionally, using hop extract in conjunction with calcium and vitamin D may enhance its effects.
FAQs
Is hop flower extract safe?
Yes, hop flower extract is generally considered safe, but caution is advised for women with estrogen-sensitive conditions.
When should I take hop flower extract?
No specific timing is recommended; however, daily consistent dosing is likely beneficial.
What results should I expect from using hop flower extract?
Expected results include improvements in bone health and a reduction in menopausal symptoms, especially for postmenopausal women.
Can hop flower extract replace my medication?
No, it should not replace medical treatment and should be used under healthcare supervision for specific health conditions.
Research Sources
- https://www.mdpi.com/2072-6643/15/12/2688 – This randomized controlled trial demonstrated that a hop extract standardized in 8-PN significantly increased total body bone mineral density in postmenopausal women compared to placebo.
- https://ijogi.mums.ac.ir/mobile/article_7797.html?lang=en – This systematic review assessed the effects of hops on menopausal vasomotor symptoms, concluding that hop extracts significantly reduce occurrences of hot flashes in affected women.
- https://f1000research.com/articles/13-790 – This safety assessment compiled data from animal studies and human observations, indicating no significant adverse effects of hop extract, while also highlighting potential estrogenic activity.
- https://www.cir-safety.org/sites/default/files/HumLup042017TR.pdf – A comprehensive safety review that addresses the general safety profile of hop extract, noting its lack of significant adverse effects, but emphasizing the need for long-term studies.
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003167.pub3/information – This Cochrane Review provides a summary of studies evaluating the efficacy of herbal medicine including hop extracts in managing menopausal symptoms, concluding moderate effectiveness for vasomotor symptoms.
Supplements Containing Hop Flower Extract
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