Hibiscus Sabdariffa Dichloromethane Extract
Also known as: Roselle Dichloromethane Extract, Hibiscus Dichloromethane Extract, Hibiscus sabdariffa Dichloromethane Extract, Hibiscus sabdariffa L. Dichloromethane Extract
Overview
Hibiscus sabdariffa L. dichloromethane extract is a specific phytochemical extract derived from the calyces of the tropical Hibiscus sabdariffa plant. Unlike more common aqueous extracts, the dichloromethane extraction method targets non-polar compounds, primarily triterpenoids and other lipophilic phytochemicals. This extract is being investigated for its potential in cardiovascular health, particularly blood pressure reduction and lipid profile improvement, and for its antidiabetic properties. While the broader research on Hibiscus sabdariffa is extensive, studies specifically on the dichloromethane extract are more limited, with most clinical evidence supporting aqueous forms. However, preclinical research highlights unique mechanisms of action for the dichloromethane extract's components.
Benefits
Clinical evidence, primarily from systematic reviews and meta-analyses of *Hibiscus sabdariffa* extracts (mostly aqueous), indicates significant reductions in both systolic and diastolic blood pressure, comparable to some antihypertensive medications. These benefits are considered clinically relevant and are supported by moderate to high-quality evidence [1, 3]. Meta-analyses also show improvements in lipid profiles, including reductions in LDL cholesterol, although some lipid outcomes may require more definitive data [1, 3]. While preclinical studies on the dichloromethane extract suggest potential antidiabetic effects through PPARδ/γ dual agonist activity, clinical evidence for glycemic control is less conclusive, with some meta-analyses showing no significant effect or insufficient data [1, 2].
How it works
The dichloromethane extract of *Hibiscus sabdariffa* contains triterpenoids that have been identified as dual agonists of peroxisome proliferator-activated receptors (PPAR) δ and γ [2]. These nuclear receptors play crucial roles in regulating lipid metabolism and glucose homeostasis. By activating these receptors, the extract's compounds may modulate metabolic pathways, potentially leading to improved glucose tolerance and lipid profiles. Additionally, the extract's general antioxidant properties and ability to improve endothelial function are thought to contribute to its blood pressure-lowering effects. The lipophilic nature of the active compounds suggests they interact with cellular membranes and intracellular signaling pathways to exert their biological effects.
Side effects
Overall, *Hibiscus sabdariffa* extracts are generally considered safe, with clinical trials reporting no serious adverse events [1, 3]. Mild and rare side effects may include gastrointestinal discomfort. While specific safety data for the dichloromethane extract are limited, its safety profile is presumed to be similar to other *Hibiscus sabdariffa* extracts. Caution is advised when combining this extract with antihypertensive or lipid-lowering medications due to potential additive effects, which could lead to excessive blood pressure or lipid reductions. No significant drug interactions or contraindications have been definitively established in high-quality studies, but individuals on medication should consult a healthcare professional.
Dosage
Effective dosages for *Hibiscus sabdariffa* extracts in clinical trials, primarily using aqueous forms for blood pressure and lipid effects, typically range from 250 mg to 1,000 mg daily [1, 3]. Specific dosing guidelines for the dichloromethane extract are less established due to limited clinical research. It is generally recommended to take the supplement once or twice daily, preferably with meals, to enhance absorption and minimize potential gastrointestinal discomfort. For consistent efficacy, standardization of the extract to its active compounds, such as triterpenoids for the dichloromethane extract, is advisable. Upper limits and safety thresholds for this specific extract type are not well-defined, necessitating adherence to product-specific recommendations.
FAQs
Is the dichloromethane extract more effective than aqueous extracts?
Clinical evidence predominantly supports aqueous extracts for blood pressure and lipid benefits. Dichloromethane extracts show promising mechanistic activity but lack extensive human clinical trials to confirm superior efficacy.
How soon can effects be observed?
Reductions in blood pressure have typically been observed within 4 to 12 weeks of consistent supplementation with *Hibiscus sabdariffa* extracts in clinical studies.
Is it safe for long-term use?
Current research supports the safety of *Hibiscus sabdariffa* extracts for up to 12 weeks of use. Longer-term safety data, especially for the dichloromethane extract, are currently limited.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9086798/ – This systematic review and meta-analysis of randomized controlled trials (RCTs) found that *Hibiscus sabdariffa* extracts significantly reduce systolic and diastolic blood pressure and improve lipid profiles. The study highlighted the clinical relevance of blood pressure reduction and noted that most included studies used aqueous extracts, indicating a need for more research on other extract types.
- https://www.bohrium.com/paper-details/triterpenoids-from-hibiscus-sabdariffa-l-with-ppar-dual-agonist-action-in-vivo-in-vitro-and-in-silico-studies/812807986819891201-11224 – This preclinical study identified triterpenoids from *Hibiscus sabdariffa* dichloromethane extract as dual agonists of PPARδ and PPARγ receptors. Through in vivo, in vitro, and in silico methods, it demonstrated the potential of these compounds to improve glucose tolerance and modulate metabolic pathways, providing a mechanistic basis for potential antidiabetic effects.
- https://pubmed.ncbi.nlm.nih.gov/34927694/ – This publication, likely related to the meta-analysis, reinforces the findings regarding *Hibiscus sabdariffa*'s efficacy in blood pressure and lipid management. It contributes to the body of evidence supporting the cardiovascular benefits of the plant, primarily based on studies using various extract forms, including aqueous.
- https://www.ijrte.org/wp-content/uploads/papers/v8i2S7/B10220782S719.pdf – This systematic review and meta-analysis focused on the effects of *Hibiscus sabdariffa* on serum lipids. It concluded that *Hibiscus sabdariffa* significantly reduced total cholesterol and LDL cholesterol, contributing to improved lipid profiles. The study noted limitations regarding the specific types of extracts studied and sample sizes in some included trials.