Hesperidin from MPFF
Also known as: Hesperidin, Hesperidin methyl chalcone, Hesperetin-7-O-rutinoside
Overview
Hesperidin is a flavonoid, specifically a flavanone glycoside, found predominantly in citrus fruits like oranges and lemons, especially in the peel. It's often used for its potential anti-inflammatory and antioxidant properties, frequently in combination with other flavonoids such as diosmin in formulations like Micronized Purified Flavonoid Fraction (MPFF). Hesperidin is recognized for its ability to support vascular health and reduce inflammation. Research on hesperidin is ongoing, with studies exploring its effects on inflammation and cardiovascular health. While some studies suggest benefits in reducing inflammation and improving vascular health, the evidence remains mixed, and further research is needed to confirm these effects. Hesperidin's bioavailability is limited due to its glycosidic form, requiring hydrolysis to its aglycone form (hesperetin) for better absorption.
Benefits
Hesperidin supplementation has demonstrated potential in improving vascular cell adhesion molecule-1 (VCAM-1) levels, which is indicative of reduced inflammation. This suggests a potential benefit in managing inflammatory conditions. Additionally, it may contribute to improved cardiovascular health by enhancing vascular function and reducing oxidative stress. These beneficial effects may be more pronounced in individuals with existing cardiovascular risk factors. However, the clinical significance of hesperidin's effects is still under investigation, and more research is needed to establish clear effect sizes and the time course of these benefits. The evidence for benefits beyond VCAM-1 reduction is currently inconsistent.
How it works
Hesperidin primarily acts through anti-inflammatory pathways, potentially modulating adhesion molecules and reducing oxidative stress. It interacts with the cardiovascular system by improving vascular function and reducing inflammation. A known molecular target is VCAM-1, with supplementation shown to decrease its levels. Hesperidin's limited bioavailability is due to its glycosidic form, which requires hydrolysis to its aglycone form (hesperetin) for better absorption. This conversion is crucial for the compound to exert its biological effects effectively.
Side effects
Hesperidin is generally considered safe when consumed in typical dietary amounts. Common side effects are not well-documented, but gastrointestinal upset is possible. Uncommon side effects are rarely reported but may include allergic reactions. Potential interactions with anticoagulants exist due to its effect on blood vessels, so caution is advised in individuals with bleeding disorders or those taking blood-thinning medications. Pregnant or breastfeeding women should consult healthcare providers before use. Due to limited research, rare side effects are not well-documented, and individuals should monitor for any adverse reactions when starting supplementation.
Dosage
The minimum effective dose for hesperidin alone is not well-established; it is often used in combination with diosmin in formulations like MPFF, where dosages vary. The maximum safe dose for hesperidin alone is also not established. There are no specific timing recommendations for hesperidin supplementation. It is often used in oral supplements. Bioavailability is improved when hesperidin is converted to its aglycone form. Due to the lack of comprehensive research, specific dosage recommendations should be made in consultation with a healthcare professional.
FAQs
What is hesperidin typically used for?
Hesperidin is often used in combination with other flavonoids, such as diosmin, for supporting vascular health and reducing inflammation. It is commonly found in supplements aimed at improving circulation.
Is hesperidin safe to take with other medications?
Hesperidin may interact with anticoagulants due to its effects on blood vessels. Individuals taking blood-thinning medications should exercise caution and consult with a healthcare provider before use.
When is the best time to take hesperidin?
There are no specific timing recommendations for hesperidin supplementation. It can be taken at any time of day, but consistency is key for potential benefits.
What are the expected benefits of taking hesperidin?
Potential benefits include reducing inflammation and improving vascular health. However, individual results may vary, and it is not a standalone treatment for cardiovascular diseases.
Is hesperidin a standalone treatment for cardiovascular issues?
No, hesperidin is not a standalone treatment for cardiovascular diseases but may be part of a broader therapeutic approach. Consult with a healthcare provider for comprehensive treatment plans.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/30991044/ – Hesperidin supplementation significantly improves VCAM-1 levels, indicating reduced inflammation. This systematic review and meta-analysis provides evidence for hesperidin's anti-inflammatory effects, although the effects on other inflammatory markers were inconsistent. The study's moderate quality is due to variability in study outcomes.
- https://becarispublishing.com/doi/10.2217/cer-2021-0038 – MPFF, which includes hesperidin-like compounds, shows promise in treating chronic venous insufficiency by improving vascular health. This narrative review provides a comprehensive overview of MPFF's effects, highlighting its potential benefits in managing venous conditions. However, the review focuses on MPFF rather than hesperidin alone.
- https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12527 – Sulodexide is more effective than MPFF in certain vascular conditions, suggesting that while MPFF (which includes flavonoids like hesperidin) has benefits, other treatments may be more effective in specific contexts. This systematic literature review and network meta-analysis provides high-quality evidence comparing different treatments for vascular conditions. The study does not focus solely on hesperidin, but provides context for its use within MPFF.
- https://journals.sagepub.com/doi/abs/10.1177/02683555211015020 – This study investigates the efficacy of MPFF in treating chronic venous disease. The findings suggest that MPFF can improve venous tone and reduce edema, contributing to symptom relief in patients with venous insufficiency. The study highlights the potential of flavonoid-based treatments in managing chronic venous disorders.
- https://www.dovepress.com/article/download/68915 – This review discusses the pharmacological properties and clinical applications of diosmin and hesperidin. It highlights their antioxidant, anti-inflammatory, and vasoprotective effects, suggesting their potential in treating various vascular disorders. The review provides a comprehensive overview of the mechanisms of action and therapeutic benefits of these flavonoids.
