Get Your Personalized Supplement StackSupplement Stack Quiz

Griffonia Simplicifolia Seed Extract

Also known as: Griffonia, 5-Hydroxytryptophan (5-HTP) seed extract, Griffonia simplicifolia

Overview

*Griffonia simplicifolia* is a tropical shrub indigenous to West Africa, celebrated for its seeds that are abundant in 5-hydroxytryptophan (5-HTP), a precursor to the neurotransmitter serotonin (5-HT). The extract is utilized primarily for its mood-enhancing properties, addressing conditions such as anxiety, depression, insomnia, chronic headaches, and fibromyalgia. The seeds can contain between 6-14% 5-HTP, and concentrated supplements can yield up to 98% purity. Although early studies on animals indicate promising effects, evidence from large-scale human trials remains sparse, necessitating further exploration of its efficacy and long-term safety.

Benefits

Research suggests multiple benefits associated with *Griffonia simplicifolia* seed extract: 1. **Anxiolytic Effects:** Animal studies demonstrate significant reduction in anxiety-like behaviors at doses of 10-25 mg/kg. 2. **Antidepressant Effects:** The extract has been shown to elevate serotonin levels, potentially alleviating depression. While promising, this evidence primarily stems from animal studies and limited human trials. 3. **Antioxidant Activity:** Exhibits ability to scavenge free radicals, indicating potential health benefits beyond mood-related conditions. Although effects are notable, they require stronger human validation.

How it works

*Griffonia simplicifolia* primarily increases serotonin (5-HT) levels through the conversion of 5-HTP in the brain. This process supports numerous physiological and psychological functions, including mood regulation, sleep-wake cycles, appetite, and pain perception. The extract's efficacy stems from its ability to cross the blood-brain barrier, impacting central neurotransmitter systems involved in mood disorders.

Side effects

While considered possibly safe at recommended doses of up to 120 mg daily for short-term use, *Griffonia simplicifolia* may cause side effects such as stomach pain, diarrhea, drowsiness, anxiety, fatigue, and headaches in over 5% of users. Rare but serious side effects, including heart problems and serotonin syndrome, particularly when used with other serotonergic medications or MAOIs, can occur. Caution is also advised during pregnancy and breastfeeding due to insufficient safety evidence. Overall, users should consult healthcare providers, especially when on concurrent medications.

Dosage

The optimal dosage for *Griffonia simplicifolia* has not been clearly defined, but a maximum of 120 mg daily is reported for short-term usage, with experimental animal studies indicating effectiveness at 10-25 mg/kg. While no specific timing guidelines exist, adhering to manufacturer instructions or healthcare provider recommendations is crucial. Given potential risks with overdosing seen in a case of 1456 mg consumption, careful monitoring is essential, especially at higher doses.

FAQs

Is it safe to combine *Griffonia simplicifolia* with other medications?

It may interact with serotonergic drugs and MAOIs, potentially leading to serious side effects. Always consult a healthcare provider before combining supplements.

How quickly can I expect results from *Griffonia simplicifolia*?

Some users may notice effects within hours, but results can vary widely based on individual biochemistry and dosage.

Are there any specific precautions for using *Griffonia simplicifolia*?

Yes, users should avoid it before surgeries due to possible interactions with anesthetics and consult healthcare providers if pregnant or breastfeeding.

What forms of *Griffonia simplicifolia* are available?

It is commonly available in capsule form, and its 5-HTP purity can differ based on extraction methods.

Research Sources

https://medcraveonline.com/IJCAM/the-different-roles-of-griffonia-simplicifolia-in-the-treatment-of-depression-a-narrative-review.html – This narrative review examines the potential benefits of 5-HTP from *Griffonia simplicifolia* for treating mood disorders. While informative, it lacks comprehensive systematic analysis.
https://pubmed.ncbi.nlm.nih.gov/37760012/ – This animal study investigates the anxiolytic-like effects of *Griffonia simplicifolia* seed extract, revealing significant behavioral changes indicative of reduced anxiety.
https://pubmed.ncbi.nlm.nih.gov/21353511/ – This in vitro and in vivo study highlights the antioxidant, antiproliferative, and antimicrobial properties of *Griffonia simplicifolia*, warranting further exploration in various health contexts.