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Gotu Kola Aerial Extract

Also known as: Centella asiatica, Gotu kola, Brahmi, Centella, Hydrocotyle, Indian pennywort, Luei gong gen, Marsh pennywort

Overview

Gotu kola, scientifically known as *Centella asiatica*, is a perennial plant native to the tropical and subtropical regions of Asia. It has a long history of use in Ayurvedic and traditional Chinese medicine. The leaves and stems of the plant are used for their medicinal properties. Gotu kola is rich in triterpenoids, carotenoids, vitamins B and C, proteins, and other phytonutrients like flavonoids, volatile oils, tannins, and polyphenols. Traditionally, it has been used to treat various conditions, including wound healing, improving mental clarity, skin conditions, respiratory infections, and venous insufficiency. Modern applications often include treatments for varicose veins and chronic venous insufficiency. While many traditional uses are claimed, limited clinical evidence supports these benefits, and more research is needed to fully understand its mechanisms and potential interactions.

Benefits

Gotu kola has shown potential benefits in several areas, although the strength of evidence varies. Some studies suggest it may help treat varicose veins and venous insufficiency; for example, studies using 60 mg of the total triterpene fraction of gotu kola (TTFCA) 2-3 times daily for 4 weeks to 6 months showed improvements in patients with venous hypertension or diabetic microangiopathy. Animal studies indicate that gotu kola extracts can speed up wound healing, but human trials are lacking. Some studies suggest it may improve cognitive function and memory, but the evidence is not strong. Animal studies have also shown antidiabetic effects, such as lowering blood glucose levels and improving metabolic markers in diabetic models. Elderly individuals may experience cognitive benefits, but robust clinical trials are needed to confirm these effects.

How it works

Gotu kola is believed to act through several mechanisms. It may inhibit acetylcholinesterase, affect certain signaling pathways, and increase dendritic length and branches of neurons, potentially enhancing learning and memory. It also possesses antioxidant, antimicrobial, and anti-inflammatory properties, which could contribute to its potential health benefits. The key triterpenoids in gotu kola, such as asiatic acid and madecassoside, are thought to be responsible for many of its biological effects. These compounds may interact with enzymes and signaling pathways involved in inflammation and neuronal health. The bioavailability of madecassoside and asiaticoside is increased when given in a standardized gotu kola extract.

Side effects

Gotu kola is generally considered safe when used in recommended doses, but there is limited clinical evidence to fully assess its safety profile. Gastrointestinal issues and allergic reactions have been reported in some cases. Due to the potential for interactions with other medications, caution is advised. Gotu kola may interact with antiepileptic drugs, potentially reducing their effective doses. It should be avoided during pregnancy and lactation due to potential emmenagogue effects. Individuals with any medical condition or those taking medications, especially antiepileptics, should consult with a healthcare provider before starting gotu kola supplementation. The lack of comprehensive clinical trials means that rare adverse effects may not be fully identified, and long-term safety data is lacking.

Dosage

The minimum effective dose of gotu kola is not well established, but studies have used doses ranging from 60-450 mg of gotu kola extract per day. For venous insufficiency, 60 mg of TTFCA 2-3 times daily for 4 weeks to 6 months has been used. For cognitive function, doses of 60-450 mg daily have been studied. The maximum safe dose is not clearly defined, but doses up to 450 mg daily have been used in some studies without significant adverse effects. There is no specific timing recommended for gotu kola supplementation, but it is typically taken orally with meals to enhance absorption. Gotu kola can be used in various forms, including capsules, creams, gels, and ointments. Bioavailability is increased when madecassoside and asiaticoside are given in a standardized extract.

FAQs

Is gotu kola safe to use?

Gotu kola is generally considered safe, but potential interactions with medications and a lack of long-term safety data are concerns. Consult a healthcare provider before use, especially if you are on other medications or have a medical condition.

When and how should I take gotu kola?

There is no specific timing recommended, but it is typically taken orally with meals. Topical forms can be applied as needed for wound healing or skin conditions.

What results can I expect from taking gotu kola?

Expected results vary depending on the use. For venous insufficiency, improvements in vein function may be seen within a few weeks to months. Cognitive improvements may be modest and take longer to manifest.

Are there any misconceptions about gotu kola?

Gotu kola is often touted for numerous health benefits, but there is limited clinical evidence to support many of these claims. It is not a cure-all and should be used with caution and under medical supervision.

Research Sources

https://www.medicalnewstoday.com/articles/gotu-kola-benefits – This article provides an overview of gotu kola's potential health benefits and traditional uses. It highlights its role in wound healing, cognitive function, and venous insufficiency, while also noting the need for more research to validate these claims.
https://www.mountsinai.org/health-library/herb/gotu-kola – This resource from Mount Sinai discusses the traditional uses of gotu kola and its potential benefits. It emphasizes the importance of consulting with a healthcare provider before using gotu kola, especially for individuals with existing medical conditions or those taking medications.
https://pubmed.ncbi.nlm.nih.gov/26602573/ – This study investigates the effects of Centella asiatica on cognitive function and mood-related outcomes through a systematic review and meta-analysis. The findings suggest some improvements, but the evidence is not strong, indicating a need for more robust clinical trials.
https://www.webmd.com/vitamins/ai/ingredientmono-753/gotu-kola – WebMD's article on gotu kola provides information on its uses, effectiveness, and potential side effects. It notes that while gotu kola is used for various conditions, more evidence is needed to rate its effectiveness for many of these uses.
https://www.drugs.com/npp/gotu-kola.html – This Drugs.com resource offers comprehensive information on gotu kola, including its uses, dosage, side effects, and interactions. It highlights the importance of consulting with a healthcare professional before using gotu kola, especially for those with pre-existing conditions or taking other medications.