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Golive Plus Immunity Probiotic Blend

Also known as: Golive Plus Immunity Probiotic Blend, Lactobacillus casei, Lactobacillus reuteri, Bifidobacterium bifidum, Streptococcus thermophilus, Probiotic blend, Immune defense probiotic, Multi-strain probiotic supplement with prebiotics and immune nutrients, Lactobacillus acidophilus

Overview

The Golive Plus Immunity Probiotic Blend is a multi-strain probiotic supplement designed to support immune function and gut health. It contains a combination of beneficial bacterial species, including Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus reuteri, Bifidobacterium bifidum, and Streptococcus thermophilus, which are known for their probiotic properties. In addition to these live microorganisms, the blend is fortified with prebiotics, which are non-digestible fibers that nourish and promote the growth of beneficial gut bacteria. The formulation also includes key immune-supportive nutrients such as Vitamin C, Vitamin D3, Zinc, Echinacea, and N-Acetyl Cysteine (NAC). This synergistic combination aims to enhance gut microbiota balance, modulate immune responses, and potentially reduce the incidence or severity of infections. While probiotics and immune modulation are well-researched areas, the specific combination of ingredients in this product leverages individual evidence bases to provide comprehensive immune support.

Benefits

The Golive Plus Immunity Probiotic Blend offers several evidence-based benefits, primarily focused on immune support and gut health. Probiotics, as a component of this blend, have been shown to reduce adverse events related to infections or treatments, with a reported relative risk (RR) of 0.62 (95% CI 0.46 to 0.83), indicating moderate certainty of benefit. A significant reduction in respiratory symptoms has been observed, particularly in hospitalized patients (RR 0.13, 95% CI 0.05 to 0.39), compared to outpatients (RR 0.65, 95% CI 0.53 to 0.79). This suggests more pronounced benefits in at-risk or hospitalized populations. The blend's probiotic strains are also known to contribute to immunomodulation by enhancing regulatory T cells and downregulating pro-inflammatory cytokines, as demonstrated in studies of similar probiotic mixtures. However, the effect on systemic inflammatory markers like C-reactive protein (CRP) remains uncertain or limited. The inclusion of Vitamin C, D3, and Zinc further supports general immune function, as these micronutrients are essential for immune cell activity. The overall quality of evidence for probiotic effects on immune outcomes is moderate, with some heterogeneity across studies.

How it works

The Golive Plus Immunity Probiotic Blend works through a multi-faceted approach, primarily targeting the gut-immune axis. The probiotic bacteria interact with intestinal epithelial cells and immune cells, including dendritic cells, macrophages, and T and B lymphocytes, to modulate both innate and adaptive immunity. This interaction leads to the induction of regulatory dendritic cells and CD4+Foxp3+ regulatory T cells, which are crucial for promoting immune tolerance and reducing inflammation. The blend influences cytokine signaling pathways, such as increasing anti-inflammatory cytokines like IL-10 and TGF-β, and downregulating pro-inflammatory Th1, Th2, and Th17 cytokines. Prebiotics in the blend enhance the growth and colonization of these beneficial bacteria in the gut. Additionally, the included vitamins (C, D3) and minerals (Zinc) are absorbed systemically, providing essential cofactors for immune cell function and overall immune system support.

Side effects

Probiotics, including those in the Golive Plus Immunity Probiotic Blend, are generally considered safe with a low incidence of adverse events. Mild gastrointestinal symptoms such as bloating or gas are possible, though not consistently reported across studies. Serious adverse events are rare and have not been significantly increased compared to placebo in reviewed research. Allergic reactions or infections are extremely rare and primarily a concern in severely immunocompromised individuals. There are no major known drug interactions, but caution is advised when used concurrently with immunosuppressants or in patients who are critically ill or severely immunocompromised, as the risk of bacteremia, though very low, could be elevated in these populations. The supplement is contraindicated in cases of severe immunodeficiency or critical illness without medical supervision. Safety in specific populations like pregnant women and children requires specific evaluation and medical consultation. Overall, the blend is well-tolerated by healthy adults when used as directed.

Dosage

For immune support, studies on probiotic blends typically use doses of 10 billion CFUs or more daily. The Golive Plus Immunity Probiotic Blend provides 25+ billion CFUs per day, which falls within the optimal dosage range for immune effects. This is combined with 1000 mg Vitamin C, Vitamin D3, Zinc, and other immune nutrients. The maximum safe dose for probiotics is generally considered up to 50 billion CFUs daily in healthy adults, with no adverse dose-related effects reported in reviewed studies for this range. The supplement should be taken daily. While the timing relative to meals may affect probiotic survival, this is not conclusively established as a critical factor for efficacy. The powder form, combined with prebiotics and vitamins, is designed to enhance synergistic effects. Adequate dietary intake of other micronutrients is important to support overall immune function, as these act as required cofactors.

FAQs

Are probiotics in Golive Plus effective for immune support?

Evidence suggests moderate benefits, particularly in reducing respiratory symptoms and adverse events in hospitalized or at-risk patients. Effects in healthy individuals may be less pronounced for some outcomes.

Is it safe to take Golive Plus daily?

Yes, the probiotics and included nutrients in Golive Plus are generally considered safe for daily use in healthy adults. Mild gastrointestinal symptoms are possible but uncommon.

How soon can benefits be seen from taking Golive Plus?

Some clinical trials have observed immune benefits and reductions in symptoms within 2 to 4 weeks of consistent daily supplementation.

Does Golive Plus help reduce inflammation?

While the blend modulates immune responses, its effects on systemic inflammatory markers like C-reactive protein (CRP) are uncertain and inconsistent across studies.

Can Golive Plus replace medications for immune conditions?

No, Golive Plus is an adjunctive supplement intended to support immune health. It is not a substitute for prescribed medical treatments or professional medical advice.

Research Sources

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0278356 – This systematic review and meta-analysis by Zhang et al. (2022) found that probiotics significantly reduced adverse events (RR 0.62) and respiratory symptoms in hospitalized patients (RR 0.13). The study noted high heterogeneity and low certainty for some outcomes, but its robust methodology provided moderate quality evidence for these benefits.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4006993/ – Plaza-Diaz et al. (2019) provided a narrative review detailing the mechanistic insights of probiotics. They explained how probiotics induce regulatory immune cells, modulate cytokine production, and contribute to reduced inflammation, offering strong relevance for understanding the biological pathways of probiotic action.
https://thelivelybrand.com/products/immune-defense – This source describes the specific formulation of the Golive Plus Immunity Probiotic Blend, detailing its multi-strain probiotic content (25+ billion CFUs), inclusion of prebiotics, and additional immune-supportive nutrients like Vitamin C, D3, Zinc, Echinacea, and NAC. It highlights the product's design for synergistic immune defense.
https://pubmed.ncbi.nlm.nih.gov/31648930/ – Mohr et al. (2020) conducted a systematic review of RCTs focusing on healthy adults. Their findings indicated a limited effect of probiotics on circulating immune and inflammatory markers in this population, suggesting that clinical benefits might be more pronounced in specific, at-risk groups rather than generally healthy individuals.