Glehnia Littoralis Root Extract
Also known as: Glehnia littoralis, Beach Silvertop, American Silvertop
Overview
*Glehnia littoralis* is a plant native to coastal regions, primarily utilized in traditional medicine for its roots and leaves. This herbal supplement has been employed for various ailments, including coughs, fever, and even more severe conditions like stroke. Recent studies have sparked interest in its potential anti-cancer and neuroprotective properties. The extract is rich in coumarin-based compounds, which are known for their antioxidant effects. While the body of research is still emerging, most evidence stems from in vitro and animal studies, indicating its pharmacological effects but requiring further human trials to substantiate these findings.
Benefits
Key evidence-based benefits of *Glehnia littoralis* root extract include its anti-cancer effects, where it shows promise in inhibiting the proliferation of breast and liver cancer cells by inducing cell cycle arrest and apoptosis. Additionally, it exhibits neuroprotective properties, which may promote neurogenesis and improve cognitive functions by modulating neuroinflammatory pathways. The antioxidant properties further enhance overall health by reducing oxidative stress. While these benefits appear promising, most evidence is derived from in vitro studies, necessitating further research in human populations to draw definitive conclusions.
How it works
The mechanism of action of *Glehnia littoralis* involves several biological pathways, including the induction of cell cycle regulation via p21 and p27, leading to cell cycle arrest in cancer cells. Additionally, it may promote apoptosis by targeting molecular pathways such as CDK4 and cyclin D1. Furthermore, it interacts with the neurological and immune systems, potentially exerting anti-inflammatory effects. However, thorough studies on absorption and bioavailability are still required to elucidate its full pharmacokinetic profile.
Side effects
*Glehnia littoralis* root extract is generally considered safe based on traditional use; however, modern safety data is sparse. Common and uncommon side effects are poorly documented due to a lack of human trials, and no specific contraindications have been established. There are concerns about potential drug interactions, yet these remain unstudied. Caution is especially warranted for pregnant or breastfeeding women, as there is insufficient data available to determine safety in these populations. It is always advisable to consult with a healthcare provider before incorporating this extract for therapeutic purposes.
Dosage
Currently, there are no established guidelines for minimum effective doses of *Glehnia littoralis* for human use. In vitro studies have utilized concentrations up to 400 μg/mL, but there is no standardized human dosing. Maximum safe doses have not been determined, nor are there specific timing considerations established for administration. The extract is typically utilized in the form of a hot water extract, but factors influencing absorption remain largely undefined. Further clinical studies are needed to establish reliable dosing recommendations.
FAQs
Is *Glehnia littoralis* safe for use?
Generally considered safe based on traditional use, but modern safety data is limited. Consult a healthcare provider prior to use.
What are the expected benefits?
Research suggests potential anti-cancer and neuroprotective effects, but these require further investigation in human studies.
Can I use *Glehnia littoralis* if I'm pregnant?
Due to insufficient safety data, pregnant or breastfeeding women should consult healthcare providers before using this extract.
Are there any known side effects?
Common and uncommon side effects are poorly documented, with no specific contraindications established as of now.
How is it typically consumed?
It is usually consumed as a hot water extract, but proper dosing and absorption specifics have not yet been defined.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/26745047/ – This in vitro study investigated the effects of *Glehnia littoralis* root extract on MCF-7 breast cancer cells, demonstrating induced G1 phase cell cycle arrest. However, the study is limited by its lack of human data.
- https://pubmed.ncbi.nlm.nih.gov/32521609/ – This in vitro study examined the effects of *Glehnia littoralis* extract on Hep3B liver cancer cells, showing that the extract induced apoptotic cell death. Similar to other studies, it highlights potential anti-cancer effects but lacks human trial data.
- https://www.mdpi.com/1422-0067/25/17/9462 – This comprehensive review on the ethnopharmacology and pharmacology of *Glehnia littoralis* summarizes traditional uses and highlights potential pharmacological effects. The review stresses the absence of significant human trial outcomes.
- https://www.mdpi.com/2227-9717/11/5/1491 – This article discusses the various applications of *Glehnia littoralis*, particularly focusing on its medicinal properties and the need for more extensive human trials to support its widespread usage.
- https://pubmed.ncbi.nlm.nih.gov/37369334/ – This recent study further explores the pharmacological characteristics of various herbal extracts, including *Glehnia littoralis*, reinforcing its potential but emphasizing the research gap in human trials.
