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Galactohydrolase Lactase

Q: Are lactase supplements safe?

Yes, lactase supplements are considered safe with minimal side effects and do not interact with most medications.

Q: When should I take lactase?

Lactase should be taken immediately before consuming foods that contain lactose to maximize digestion.

Q: What results can I expect from taking lactase?

You should notice a reduction in symptoms of lactose intolerance within hours after taking lactase with dairy products.

Q: Can lactase cure lactose intolerance?

No, lactase supplements do not cure lactose intolerance; they help manage the symptoms by aiding in the digestion of lactose.

Also known as: Lactase-phlorizin hydrolase, LPH, Lactase enzyme, β-galactosidase, Lactase

Overview

Lactase is a glycoside hydrolase enzyme that catalyzes the hydrolysis of lactose into glucose and galactose, which are absorbed by the intestine. It is primarily produced in the small intestinal brush border of mammals, especially during infancy. In many adults, lactase production declines due to genetic factors, leading to lactose intolerance, a condition that affects the digestive system. Lactase supplements are commonly used to alleviate symptoms of lactose intolerance, allowing individuals to digest lactose-containing foods without discomfort. The enzyme occurs in various supplement forms such as capsules, tablets, and liquids, aiding individuals in achieving adequate dairy consumption and nutritional balance.

Benefits

Lactase supplements have been shown to significantly reduce symptoms of lactose intolerance, such as bloating, abdominal pain, and diarrhea, by enhancing lactose digestion. Systematic reviews indicate that these supplements can increase blood glucose levels by 20 mg/dL or more after lactose ingestion, demonstrating significant improvement in lactose absorption. Those with primary lactose intolerance, particularly those genetically predisposed to lactase non-persistence, can derive substantial benefits from these supplements. Long-term use enables lactose-intolerant individuals to maintain their dietary habits involving dairy, providing further evidence of improved gastrointestinal outcomes following supplementation.

How it works

Lactase acts by hydrolyzing lactose into glucose and galactose, which are then absorbed by the intestinal cells through the sodium/glucose co-transporter (SGLT1). It is localized at the brush border membrane of enterocytes in the small intestine, where it promptly interacts with dietary lactose. The enzyme performs its function in the intestinal lumen, breaking the β-glycosidic bond in lactose, making it available for absorption and thus alleviating symptoms associated with lactose intolerance.

Side effects

Lactase supplements are generally considered safe and well-tolerated, with no significant side effects recorded. Common side effects (>5%) and uncommon side effects (1-5%) have not been consistently reported in studies. Rare side effects (<1%) are also not documented. There are no known serious drug interactions associated with lactase supplementation, and the enzyme can be used safely without contraindications except in individuals with underlying gastrointestinal issues who should consult a healthcare provider prior to use. Overall, lactase supplementation poses minimal risk, making it a preferred option for managing lactose intolerance.

Dosage

The effective dosage for lactase supplements typically ranges from 2,000 to 9,000 units per intake, depending on the lactose content of the meal. It is recommended to take lactase just before consuming lactose-containing foods to ensure optimal efficacy. While the exact dosage may vary based on individual tolerance and product formulation, there is no established upper limit, as doses beyond 9,000 units are generally unnecessary. Lactase is available in various forms including capsules, tablets, and liquids, with the latter being suggested for those who prefer not to swallow pills. No co-factors are required for lactase's enzymatic activity, allowing it to act effectively in the gastrointestinal tract.

FAQs

Are lactase supplements safe?

Yes, lactase supplements are considered safe with minimal side effects and do not interact with most medications.

When should I take lactase?

Lactase should be taken immediately before consuming foods that contain lactose to maximize digestion.

What results can I expect from taking lactase?

You should notice a reduction in symptoms of lactose intolerance within hours after taking lactase with dairy products.

Can lactase cure lactose intolerance?

No, lactase supplements do not cure lactose intolerance; they help manage the symptoms by aiding in the digestion of lactose.

Research Sources

https://westminsteru.edu/student-life/the-myriad/in-vitro-analysis-of-lactase-activity-in-commercial-probiotics.html – This study analyzed the enzymatic activity of different commercial lactase supplements, emphasizing the importance of proper laboratory techniques to assess their efficacy.
https://pubmed.ncbi.nlm.nih.gov/30462373/ – The research demonstrated the dominant-negative effect of certain lactase gene variants on enzyme activity, shedding light on the genetic basis of lactose intolerance.
https://gut.bmj.com/content/73/10/e16 – This comprehensive review summarized the global prevalence and management of lactose malabsorption, highlighting the role of lactase supplements in treatment.
https://www.ncbi.nlm.nih.gov/books/NBK532285/ – This resource provided an overview of lactose intolerance, detailing the mechanisms behind lactose malabsorption and discussing management strategies.
https://gut.bmj.com/content/68/11/2080 – This publication outlined the varying degrees of lactose intolerance in different populations, emphasizing the significance of lactase supplements in dietary management.