Fermented Organic Royal Agaricus Mushroom
Also known as: Royal Agaricus Mushroom, Royal Sun Agaricus, Agaricus brasiliensis, Agaricus blazei, *Agaricus blazei*
Overview
Agaricus blazei, commonly known as the Royal Agaricus Mushroom, is a species native to Brazil, now grown worldwide. It is recognized for its medicinal properties, including antimicrobial, anti-inflammatory, and immunomodulatory effects. This mushroom contains a variety of bioactive compounds, such as polysaccharides, phenolic compounds, and ergosterol, contributing to its health benefits. While preclinical studies and some clinical trials have demonstrated its potential therapeutic effects, the research maturity level indicates a need for more human studies to fully elucidate its effects, mechanisms, and safety profiles. The quality of available evidence is primarily derived from animal models, highlighting a gap that necessitates further exploration in human populations.
Benefits
Key benefits of *Agaricus blazei* include its antimicrobial activity, particularly against Gram-negative and Gram-positive bacteria, including MRSA. Evidence suggests significant antimicrobial efficacy, with Minimum Inhibitory Concentration (MIC) values at 0.5 mg/mL for certain phenolic compounds. Additionally, its immunomodulatory properties have been shown to enhance survival rates in septic mice, suggesting potential benefits for individuals with compromised immune systems. The mushroom also exhibits antioxidant and anti-inflammatory properties, reducing oxidative stress markers and increasing bacterial clearance. Secondary benefits include potential improvements in gut health due to its prebiotic effects observed with related mushroom polysaccharides. While effect sizes vary, notable reductions in inflammatory markers have been documented, emphasizing the need for clinical validation.
How it works
The mechanisms behind *Agaricus blazei*'s effects are multifaceted. Its antimicrobial activity is primarily attributed to phenolic compounds that disrupt bacterial cell walls and membranes. Immunomodulatory effects are linked to the modulation of cytokine production, specifically reducing pro-inflammatory cytokines such as IL-1β and TNF-α, thereby enhancing phagocytosis and nitric oxide production in immune cells. The mushroom also influences the gastrointestinal system by regulating gut microbiota, fostering a beneficial environment that promotes health and potentially mitigates gastrointestinal disorders.
Side effects
Currently, *Agaricus blazei* is considered safe when consumed in moderation. Preclinical studies indicate minimal adverse effects, as no common side effects exceeding 5% incidence have been reported. Uncommon side effects occur in less than 5% of users, and no rare side effects have been documented in the literature. However, as the safety profile in humans is not fully established, caution is advised, particularly for individuals using immunosuppressive medications due to its immunomodulatory capacity. There are no known contraindications, but individuals with severe immune disorders should consult healthcare professionals before use, and pregnant or breastfeeding women should utilize it with caution due to a lack of specific research.
Dosage
The established dosage for *Agaricus blazei* remains unclear, but animal studies suggest effective doses between 100-200 mg/kg, with the minimum effective dose cited around 135 mg/kg for aqueous extracts. Maximum safety thresholds are not well defined, yet doses up to 200 mg/kg have been tolerated without adverse effects in animal models. Although human dosage protocols are lacking, aqueous extracts are known to possess significant bioactivity, and absorption may vary based on extraction methods. Viewing this, it is prudent to maintain a balanced diet and hydration for enhanced absorption while using these supplements.
FAQs
Is *Agaricus blazei* safe to consume?
Generally deemed safe in moderation, more human studies are needed for long-term safety assessments.
How should I take *Agaricus blazei*?
Pre-treatment has shown benefits in animal studies; however, human timing and administration protocols are not well established.
What results can I expect from taking *Agaricus blazei*?
Anticipated results include enhanced immune function, reduced inflammation, and potential prebiotic effects.
Are there any misconceptions about *Agaricus blazei*?
It is not a cure-all but a supplement with potential health benefits that require further clinical validation.
Research Sources
- https://www.scielo.br/j/rbfar/a/8St7yBCsYMBjTwZsjCkLg8k/?lang=en – This integrative review assesses the antimicrobial properties of *Agaricus blazei*, demonstrating its effectiveness against various bacteria, including MRSA, primarily due to its phenolic compounds. However, the review emphasizes that all included studies were preclinical.
- https://pubmed.ncbi.nlm.nih.gov/32653808/ – This systematic review discusses the health effects of *Agaricus bisporus*, highlighting its benefits for metabolic syndrome and immune function but acknowledging that its findings should not be directly extrapolated to *Agaricus blazei*.
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01238/full – In this animal study, the aqueous extract of *Agaricus brasiliensis* was shown to improve survival rates and reduce inflammatory responses in a sepsis model, underscoring immunomodulatory properties similar to those expected from *Agaricus blazei*.
- https://www.mdpi.com/2304-8158/12/4/859 – This study reviews the bioactive components of various mushrooms and discusses their effects on health, specifically focusing on *Agaricus* species and advocating for further research on their health benefits.
- https://www.mdpi.com/2072-6643/12/5/1339 – This article explores the nutritional aspects of mushrooms, including *Agaricus*, and outlines the potential health benefits associated with their consumption, providing insight into their role in a balanced diet.
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