Fadogia Agrestis PE
Also known as: Fadogia agrestis, Black aphrodisiac, Fadogia, Fadogia agrestis stem extract
Overview
Fadogia agrestis is a shrub native to Nigeria, traditionally used in folk medicine. It is marketed as a supplement for increasing testosterone, enhancing libido, and improving sexual function, and is also sometimes used to improve athletic performance. The primary bioactive constituents are believed to be glycosides and saponins. Research on Fadogia agrestis is in its early stages, with most studies being conducted on animals. These studies suggest potential aphrodisiac and pro-erectile effects, but there is a lack of robust human clinical trials to confirm these benefits. The available evidence is of low quality, and no systematic reviews or meta-analyses in humans exist. Therefore, the effects observed in animal models may not directly translate to humans. Due to limited human data, the efficacy and safety of Fadogia agrestis in humans remain uncertain.
Benefits
In rodent studies, Fadogia agrestis supplementation (18–100 mg/kg for 5 days) increased testosterone levels by 2- to 6-fold and enhanced libido. Testicular weight also increased by 11–15%. Additionally, some studies reported an increase in ejaculation latency. While these effects are promising, it's important to note that these benefits have only been observed in animal models. There is currently no human data to support these claims, and the clinical relevance of these findings remains uncertain. Therefore, the potential benefits of Fadogia agrestis for humans, particularly those with low libido or testosterone, are still speculative and require further investigation.
How it works
The proposed mechanism of action for Fadogia agrestis involves direct stimulation of testicular function, leading to increased testosterone synthesis. Animal studies suggest that it acts on the hypothalamic-pituitary-gonadal axis. While the exact molecular targets are not fully understood, it is believed that glycosides and saponins, the main bioactive constituents, play a role in these processes. However, the absorption and bioavailability of Fadogia agrestis are not well-defined, especially in humans. Animal studies suggest oral bioavailability, but specific details are lacking. Further research is needed to fully elucidate the mechanisms of action and pharmacokinetic properties of Fadogia agrestis.
Side effects
Due to insufficient data, a comprehensive safety assessment of Fadogia agrestis in humans is not possible. Animal studies have raised concerns about potential liver and kidney toxicity at high doses. Common, uncommon, and rare side effects have not been reported in humans. There is also no available data on drug interactions. Due to the lack of safety data, Fadogia agrestis should be avoided during pregnancy and breastfeeding. It is also not recommended for children or individuals with pre-existing liver or kidney disease. Given the potential for toxicity observed in animal studies, caution is advised when considering Fadogia agrestis supplementation.
Dosage
The minimum effective dose, optimal dosage ranges, and maximum safe dose of Fadogia agrestis have not been established in humans. Animal studies have used dosages ranging from 18–100 mg/kg. However, human equivalent doses are speculative. There is no human data on timing considerations; animal studies used daily dosing for 5 days. The stem extract is the most commonly used form, but there are no standardized preparations. Absorption factors are also not well-understood in humans, although animal studies suggest oral bioavailability. Until further research is conducted, specific dosage recommendations for Fadogia agrestis in humans cannot be provided.
FAQs
Is Fadogia agrestis safe?
Safety in humans is not established. Animal studies suggest potential liver and kidney toxicity at high doses, so caution is advised.
How should I take Fadogia agrestis?
There is no human data to guide administration. Animal studies suggest daily oral administration, but this may not be applicable to humans.
What results can I expect from taking Fadogia agrestis?
In animals, increased testosterone and libido have been observed. However, the effects in humans are currently unknown and not well-supported.
Are claims of Fadogia agrestis's efficacy in humans supported by evidence?
No, claims of proven efficacy in humans are not supported by current evidence. Research is limited to animal studies.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6920068/ – This study investigated the effects of Fadogia agrestis on reproductive function in male rats. The results showed that Fadogia agrestis increased serum testosterone levels and improved sexual behavior in the treated animals, suggesting a potential role in managing sexual dysfunction. However, the study also noted the need for further research to determine the safety and efficacy of Fadogia agrestis in humans.
- https://pubmed.ncbi.nlm.nih.gov/16281088/ – This study examined the effects of Fadogia agrestis stem extract on the sexual behavior of male rats. The findings indicated that the extract significantly increased mounting frequency and reduced ejaculation latency, suggesting an aphrodisiac effect. The study concluded that Fadogia agrestis could potentially be used to manage erectile dysfunction, but further research is necessary to confirm these effects and assess safety.
- https://examine.com/supplements/fadogia-agrestis/ – Examine.com provides a summary of the available research on Fadogia agrestis, primarily focusing on animal studies. It highlights the potential for increased testosterone and libido but emphasizes the lack of human clinical trials. The summary also notes potential toxicity at high doses, underscoring the need for caution and further research before widespread use in humans.
- https://www.webmd.com/vitamins/ai/ingredientmono-1162/fadogia-agrestis – WebMD provides information on Fadogia agrestis, noting the insufficient data on its safety and efficacy in humans. It mentions the traditional use of the plant for various conditions but cautions that there is limited scientific evidence to support these uses. The resource also highlights the potential for liver and kidney toxicity in animals, advising caution due to the lack of human clinical data.
- https://primehealthdenver.com/best-testosterone-booster/ – PrimeHealth Denver's article discusses Fadogia agrestis as a potential testosterone booster. It acknowledges the animal studies suggesting benefits for testosterone levels and sexual function but emphasizes the absence of human clinical trials. The article also points out the potential risks and side effects observed in animal studies, recommending caution and further research before considering Fadogia agrestis supplementation.
